The NMDA receptor antagonist memantine as a symptomatological and neuroprotective treatment for Alzheimer's disease: preclinical evidence (Q35218757)

7 August 2017

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title

The NMDA receptor antagonist memantine as a symptomatological and neuroprotective treatment for Alzheimer's disease: preclinical evidence (English)

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7 August 2017

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1

Wojciech Danysz

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7 August 2017

Chris G Parsons

2

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PubMed ID

12973747

7 August 2017

language of work or name

English

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publication date

1 September 2003

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International Journal of Geriatric Psychiatry

7 August 2017

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7 August 2017

18

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7 August 2017

S23-32

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7 August 2017

Suppl 1

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Alternative excitotoxic hypotheses

7 August 2017

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The role of glutamate in neurotransmission and in neurologic disease

21 January 2018

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Neuroprotective and cognition-enhancing properties of MK-801 flexible analogs. Structure-activity relationships.

21 January 2018

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7 January 2021

Effects of the uncompetitive NMDA receptor antagonist memantine on hippocampal long-term potentiation, short-term exploratory modulation and spatial memory in awake, freely moving rats.

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7 January 2021

Staging of Alzheimer-related cortical destruction

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7 January 2021

The Ca2+ influx induced by beta-amyloid peptide 25-35 in cultured hippocampal neurons results from network excitation

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7 January 2021

The time course of glutamate in the synaptic cleft

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7 January 2021

beta-Amyloid produces a delayed NMDA receptor-dependent reduction in synaptic transmission in rat hippocampus.

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7 January 2021

Neuroprotective and symptomatological action of memantine relevant for Alzheimer's disease--a unified glutamatergic hypothesis on the mechanism of action.

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7 January 2021

Cortical pyramidal neurone loss may cause glutamatergic hypoactivity and cognitive impairment in Alzheimer's disease: investigative and therapeutic perspectives

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7 January 2021

Memantine restores long term potentiation impaired by tonic N-methyl-D-aspartate (NMDA) receptor activation following reduction of Mg2+ in hippocampal slices.

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7 January 2021

Senile plaques stimulate microglia to release a neurotoxin found in Alzheimer brain.

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7 January 2021

Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologically

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7 January 2021

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice.

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7 January 2021

beta-Amyloid peptide-derived, oxygen-dependent free radicals inhibit glutamate uptake in cultured astrocytes: implications for Alzheimer's disease.

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7 January 2021

Amyloid beta peptide (25-35) inhibits Na+-dependent glutamate uptake in rat hippocampal astrocyte cultures

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7 January 2021

Nitrone-based free radical traps as neuroprotective agents in cerebral ischaemia and other pathologies.

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7 January 2021

Distribution of glutamate receptor subunit NMDAR1 in the hippocampus of normal elderly and patients with Alzheimer's disease.

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7 January 2021

beta-amyloid protein enhances macrophage production of oxygen free radicals and glutamate

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7 January 2021

Beta-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

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7 January 2021

(3H]MK-801 binding sites in postmortem brain regions of schizophrenic patients

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7 January 2021

Contributory mechanisms in the causation of neurodegenerative disorders

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7 January 2021

Glutamate transporter alterations in Alzheimer disease are possibly associated with abnormal APP expression.

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7 January 2021

Excitatory amino acids as a final common pathway for neurologic disorders.

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7 January 2021

Memantine, but not dizocilpine, ameliorates cognitive deficits in adult rats withdrawn from chronic ingestion of alcohol

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7 January 2021

Deficient glutamate transport is associated with neurodegeneration in Alzheimer's disease

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7 January 2021

Caspase dependent DNA fragmentation might be associated with excitotoxicity in Alzheimer disease

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7 January 2021

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

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7 January 2021

Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis

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7 January 2021

Neuroprotection by memantine against neurodegeneration induced by beta-amyloid(1-40).

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7 January 2021

Learning deficits induced by chronic intraventricular infusion of quinolinic acid--protection by MK-801 and memantine

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7 January 2021

Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

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7 January 2021

Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice.

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7 January 2021

Glutamate release from microglia via glutamate transporter is enhanced by amyloid-beta peptide

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7 January 2021

Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist--a review of preclinical data

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7 January 2021

Patch clamp studies on the kinetics and selectivity of N-methyl-D-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan).

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7 January 2021

Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease

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7 January 2021

Memantine in moderate-to-severe Alzheimer's disease

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7 January 2021

Quantitative morphology and regional and laminar distributions of senile plaques in Alzheimer's disease.

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7 January 2021

Mutant presenilins disturb neuronal calcium homeostasis in the brain of transgenic mice, decreasing the threshold for excitotoxicity and facilitating long-term potentiation

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7 January 2021

Neuroprotection by the NMDA receptor-associated open-channel blocker memantine in a photothrombotic model of cerebral focal ischemia in neonatal rat.

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7 January 2021

Investigations of neurotoxicity and neuroprotection within the nucleus basalis of the rat.

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7 January 2021

MK-801, memantine and amantadine show neuroprotective activity in the nucleus basalis magnocellularis

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7 January 2021

The effects of mitochondrial failure upon cholinergic toxicity in the nucleus basalis

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7 January 2021

The cytotoxicity of chronic neuroinflammation upon basal forebrain cholinergic neurons of rats can be attenuated by glutamatergic antagonism or cyclooxygenase-2 inhibition

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7 January 2021

Memantine in severe dementia: results of the 9M-Best Study (Benefit and efficacy in severely demented patients during treatment with memantine).

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7 January 2021

Uncompetitive NMDA receptor antagonists attenuate NMDA-induced impairment of passive avoidance learning and LTP.

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7 January 2021

Infusion of (+) -MK-801 and memantine -- contrasting effects on radial maze learning in rats with entorhinal cortex lesion.

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7 January 2021

Identifiers

DOI

10.1002/GPS.938

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7 August 2017

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PubMed ID

12973747