Chemical probes for the functionalization of polyketide intermediates (Q35248736)

7 August 2017

Chemical probes for the functionalization of polyketide intermediates (English)

1 reference

7 August 2017

Manuela Tosin

7

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Peter Leadlay

object named as

Peter F Leadlay

6

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Silvia Gazzola

object named as

Silvia Gazzola

3

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author name string

Elena Riva

1

1 reference

7 August 2017

Ina Wilkening

2

1 reference

7 August 2017

W M Ariel Li

4

1 reference

7 August 2017

Luke Smith

5

1 reference

7 August 2017

language of work or name

English

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publication date

11 September 2014

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Angewandte Chemie International Edition

7 August 2017

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volume

53

1 reference

7 August 2017

44

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7 August 2017

11944-11949

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Structural rearrangements of a polyketide synthase module during its catalytic cycle

7 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4501312

Natural and engineered biosynthesis of fluorinated natural products.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4501312

Intermediates in monensin biosynthesis: A late step in biosynthesis of the polyether ionophore monensin is crucial for the integrity of cation binding

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4501312

Steps towards the synthetic biology of polyketide biosynthesis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4501312

Fluorine in pharmaceutical industry: fluorine-containing drugs introduced to the market in the last decade (2001-2011).

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4501312

Expanding the fluorine chemistry of living systems using engineered polyketide synthase pathways.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4501312

Expanding the structural diversity of polyketides by exploring the cofactor tolerance of an inline methyltransferase domain

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4501312

Exploration of fluorine chemistry at the multidisciplinary interface of chemistry and biology.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4501312

Minimally invasive mutagenesis gives rise to a biosynthetic polyketide library.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4501312

The generation of "unnatural" products: synthetic biology meets synthetic chemistry

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4501312

Merging chemical synthesis and biosynthesis: a new chapter in the total synthesis of natural products and natural product libraries

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4501312

Natural products as sources of new drugs over the 30 years from 1981 to 2010

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4501312

Bioconjugation via azide-Staudinger ligation: an overview.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4501312

Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4501312

Bioorthogonal chemistry: fishing for selectivity in a sea of functionality

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4501312

Identification of selective inhibitors of cancer stem cells by high-throughput screening

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4501312

A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4501312

Carboxylic ionophores in malaria chemotherapy: the effects of monensin and nigericin on Plasmodium falciparum in vitro and Plasmodium vinckei petteri in vivo

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4501312

Natural products and Pharma 2011: strategic changes spur new opportunities

27 July 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201407448

Accumulation of an E,E,E-triene by the monensin-producing polyketide synthase when oxidative cyclization is blocked

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201407448

Promiscuity of a modular polyketide synthase towards natural and non-natural extender units.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201407448

Enzyme-directed mutasynthesis: a combined experimental and theoretical approach to substrate recognition of a polyketide synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201407448

Malonyl carba(dethia)- and malonyl oxa(dethia)-coenzyme A as tools for trapping polyketide intermediates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201407448

Synthetic chain terminators off-load intermediates from a type I polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201407448

In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201407448

Insights into lasalocid A ring formation by chemical chain termination in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201407448

Chemical reporters for biological discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201407448

Chemoselective Staudinger-phosphite reaction of azides for the phosphorylation of proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201407448

Chemoselective Staudinger-phosphite reaction of symmetrical glycosyl-phosphites with azido-peptides and polygycerols.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201407448

One-pot synthesis and cytotoxicity studies of new Mannich base derivatives of polyether antibiotic--lasalocid acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201407448

Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201407448

Structure of a modular polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201407448

Structures and properties of naturally occurring polyether antibiotics

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4501312

Chapter 1 Introduction to Polyketide Biosynthesis

26 September 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201407448

A hybrid modular polyketide synthase obtained by domain swapping

21 January 2018

1 reference

12 December 2020

Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase

1 reference

12 December 2020

Mutational biosynthesis of ansamitocin antibiotics: a diversity-oriented approach to exploit biosynthetic flexibility

1 reference

12 December 2020

Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage

1 reference

12 December 2020

Fluorine in medicinal chemistry

1 reference

12 December 2020

Identifiers

DOI

10.1002/ANIE.201407448

1 reference

7 August 2017

1 reference

7 August 2017

1 reference