Anti-inflammatory properties of lipid oxidation products (Q35298513)

7 August 2017

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title

Anti-inflammatory properties of lipid oxidation products (English)

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7 August 2017

2

Norbert Leitinger

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7 August 2017

Valery N Bochkov

1

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7 August 2017

6 September 2003

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Journal of Molecular Medicine

7 August 2017

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7 August 2017

81

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7 August 2017

613-626

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7 August 2017

10

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https://scigraph.springernature.com/pub.10.1007/s00109-003-0467-2

7 August 2017

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Decreased inducibility of TNF expression in lipid-loaded macrophages

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12 December 2020

Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-kappaB-mediated transcription

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12 December 2020

Inhibition of stimulus-induced endothelial cell intercellular adhesion molecule-1, E-selectin, and vascular cellular adhesion molecule-1 expression by arachidonic acid and its hydroxy and hydroperoxy derivatives

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12 December 2020

Cyclooxygenase-2 is induced in monocytes by peroxisome proliferator activated receptor gamma and oxidized alkyl phospholipids from oxidized low density lipoprotein

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12 December 2020

Oxidized phospholipids stimulate tissue factor expression in human endothelial cells via activation of ERK/EGR-1 and Ca(++)/NFAT.

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12 December 2020

Vitamin C blocks inflammatory platelet-activating factor mimetics created by cigarette smoking

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12 December 2020

Biologically active oxidized phospholipids

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12 December 2020

Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury

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12 December 2020

Core aldehydes of alkyl glycerophosphocholines in atheroma induce platelet aggregation and inhibit endothelium-dependent arterial relaxation

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12 December 2020

Dualism of oxidized lipoproteins in provoking and attenuating the oxidative burst in macrophages: role of peroxisome proliferator-activated receptor-gamma

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12 December 2020

Oxidized phospholipids and isoprostanes in atherosclerosis

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12 December 2020

The lipid peroxidation end product 4-hydroxy-2,3-nonenal up-regulates transforming growth factor beta1 expression in the macrophage lineage: a link between oxidative injury and fibrosclerosis

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12 December 2020

Oxidized lipoproteins including HDL and their lipid peroxidation products inhibit TNF-alpha secretion by THP-1 human macrophages

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12 December 2020

Initial responses to endotoxins and Gram-negative bacteria

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12 December 2020

Oxysterols: friends, foes, or just fellow passengers?

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12 December 2020

Vascular inflammation is negatively autoregulated by interaction between CCAAT/enhancer-binding protein-delta and peroxisome proliferator-activated receptor-gamma

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12 December 2020

Effect of platelet activating factor-acetylhydrolase on the formation and action of minimally oxidized low density lipoprotein

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12 December 2020

4-Hydroxynonenal prevents NF-kappaB activation and tumor necrosis factor expression by inhibiting IkappaB phosphorylation and subsequent proteolysis.

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12 December 2020

Resolution of inflammation.

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12 December 2020

Phagocytes and oxidative stress

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12 December 2020

Oxidized cholesteryl linoleates stimulate endothelial cells to bind monocytes via the extracellular signal-regulated kinase 1/2 pathway

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12 December 2020

Effects of oxidized LDL on mononuclear phagocytes: inhibition of induction of four inflammatory cytokine gene RNAs, release of NO, and cytolysis of tumor cells

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12 December 2020

Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1

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12 December 2020

LXRs; oxysterol-activated nuclear receptors that regulate genes controlling lipid homeostasis

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12 December 2020

Toll-like receptor-4 is involved in eliciting an LPS-induced oxidative burst in neutrophils.

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12 December 2020

Oxidized LDL reduces monocyte CCR2 expression through pathways involving peroxisome proliferator-activated receptor gamma

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12 December 2020

Novel function of lecithin-cholesterol acyltransferase. Hydrolysis of oxidized polar phospholipids generated during lipoprotein oxidation

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12 December 2020

Cyclic AMP-dependent inhibition of human neutrophil oxidative activity by substituted 2-propynylcyclohexyl adenosine A(2A) receptor agonists

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12 December 2020

Chlamydia pneumoniae activates IKK/I kappa B-mediated signaling, which is inhibited by 4-HNE and following primary exposure

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12 December 2020

Minimally modified low-density lipoprotein induces monocyte adhesion to endothelial connecting segment-1 by activating beta1 integrin.

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12 December 2020

Possible new role for NF-kappaB in the resolution of inflammation.

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12 December 2020

HDL and the inflammatory response induced by LDL-derived oxidized phospholipids

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12 December 2020

Peroxisome Proliferator-activated Receptor α Activation Modulates Cellular Redox Status, Represses Nuclear Factor-κB Signaling, and Reduces Inflammatory Cytokine Production in Aging

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12 December 2020

Heme oxygenase-1: the "emerging molecule" has arrived

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12 December 2020

Dysregulation of monocytic nuclear factor-kappa B by oxidized low-density lipoprotein

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12 December 2020

Inhibition of mouse macrophage degradation of acetyl-low density lipoprotein by interferon-gamma

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12 December 2020

NADPH oxidase-dependent oxidation and externalization of phosphatidylserine during apoptosis in Me2SO-differentiated HL-60 cells. Role in phagocytic clearance

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12 December 2020

cAMP and tumor necrosis factor competitively regulate transcriptional activation through and nuclear factor binding to the cAMP-responsive element/activating transcription factor element of the endothelial leukocyte adhesion molecule-1 (E-selectin)

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12 December 2020

Evidence for a role of phospholipid oxidation products in atherogenesis

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12 December 2020

Peroxisome proliferator-activated receptor-gamma activation inhibits interleukin-1beta -mediated platelet-derived growth factor-alpha receptor gene expression via CCAAT/enhancer-binding protein-delta in vascular smooth muscle cells

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12 December 2020

The endotoxin-lipoprotein hypothesis

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12 December 2020

Role for peroxisome proliferator-activated receptor alpha in oxidized phospholipid-induced synthesis of monocyte chemotactic protein-1 and interleukin-8 by endothelial cells

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12 December 2020

IkappaB kinase, a molecular target for inhibition by 4-hydroxy-2-nonenal

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12 December 2020

Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300

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12 December 2020

A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions.

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12 December 2020

Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor gamma ligands and agonists

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12 December 2020

Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma

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12 December 2020

Oxidized LDL induces transcription factor activator protein-1 but inhibits activation of nuclear factor-kappa B in human vascular smooth muscle cells

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12 December 2020

Protective role of phospholipid oxidation products in endotoxin-induced tissue damage

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12 December 2020

The role of high density lipoprotein in sepsis.

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12 December 2020

Priming of polymorphonuclear granulocytes by lipopolysaccharides and its complexes with lipopolysaccharide binding protein and high density lipoprotein.

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12 December 2020

Monocyte binding to endothelial cells induced by oxidized phospholipids present in minimally oxidized low density lipoprotein is inhibited by a platelet activating factor receptor antagonist

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12 December 2020

Lipid oxidation products in cell signaling

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12 December 2020

Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing.

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12 December 2020

Heme oxygenase/carbon monoxide signaling pathways: regulation and functional significance

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12 December 2020

Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase

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12 December 2020

Determinants of bioactivity of oxidized phospholipids. Specific oxidized fatty acyl groups at the sn-2 position

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12 December 2020

Minimally modified low density lipoprotein stimulates monocyte endothelial interactions

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12 December 2020

The oxidative modification hypothesis of atherogenesis: an overview

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12 December 2020

25-hydroxycholesterol induces lipopolysaccharide-tolerance and decreases a lipopolysaccharide-induced TNF-alpha secretion in macrophages

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12 December 2020

Identification of macrophage liver X receptors as inhibitors of atherosclerosis

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12 December 2020

Elevated cyclic AMP inhibits NF-kappaB-mediated transcription in human monocytic cells and endothelial cells.

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12 December 2020

Inhibition of E-selectin gene expression by transforming growth factor beta in endothelial cells involves coactivator integration of Smad and nuclear factor kappaB-mediated signals

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12 December 2020

The peroxisome proliferator-activated receptors: ligands and activators

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12 December 2020

The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism

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12 December 2020

Infection and inflammation induce LDL oxidation in vivo

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12 December 2020

High density associated enzymes: their role in vascular biology.

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12 December 2020

Induction of cyclooxygenase-2 by heat shock protein 60 in macrophages and endothelial cells.

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12 December 2020

The oxidation of lipoproteins by monocytes-macrophages. Biochemical and biological mechanisms

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12 December 2020

LDL modification by activated polymorphonuclear leukocytes: a cellular model of mild oxidative stress

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12 December 2020

The orphan nuclear receptor small heterodimer partner as a novel coregulator of nuclear factor-kappa b in oxidized low density lipoprotein-treated macrophage cell line RAW 264.7.

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12 December 2020

Is NF-kappaB the sensor of oxidative stress?

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12 December 2020

Low density lipoprotein oxidation and its pathobiological significance

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12 December 2020

Oxidized low density lipoprotein suppresses the expression of tumor necrosis factor-alpha mRNA in stimulated murine peritoneal macrophages

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12 December 2020

15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway.

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12 December 2020

The role of oxidized lipoproteins in atherogenesis

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12 December 2020

Anti-inflammatory mechanisms in the vascular wall.

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12 December 2020

Obligatory role of cyclic adenosine monophosphate response element in cyclooxygenase-2 promoter induction and feedback regulation by inflammatory mediators

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12 December 2020

Oxidized lipids as mediators of coronary heart disease

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12 December 2020

Platelet-activating factor acetylhydrolase deficiency. A missense mutation near the active site of an anti-inflammatory phospholipase

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12 December 2020

Oxidized phospholipids activate PPARα in a phospholipase A2-dependent manner

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12 December 2020

The isoprostane 8-iso-PGF(2alpha) stimulates endothelial cells to bind monocytes: differences from thromboxane-mediated endothelial activation.

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12 December 2020

Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species

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12 December 2020

Inflammation, bioactive lipids and atherosclerosis: potential roles of a lipoprotein-associated phospholipase A2, platelet activating factor-acetylhydrolase

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12 December 2020

Induction of monocyte binding to endothelial cells by MM-LDL: role of lipoxygenase metabolites

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12 December 2020

Platelet-activating factor acetylhydrolases in health and disease

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12 December 2020

Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway

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12 December 2020

PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines

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12 December 2020

Synthetic LXR ligand inhibits the development of atherosclerosis in mice

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12 December 2020

Oxidized LDL and HDL: antagonists in atherothrombosis

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12 December 2020

Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice

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12 December 2020

Oxidized LDLs alter the activity of the ubiquitin-proteasome pathway: potential role in oxidized LDL-induced apoptosis.

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12 December 2020

Inhibition of the RelA(p65) NF-kappaB subunit by Egr-1.

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12 December 2020

Elevated cyclic AMP inhibits endothelial cell synthesis and expression of TNF-induced endothelial leukocyte adhesion molecule-1, and vascular cell adhesion molecule-1, but not intercellular adhesion molecule-1

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12 December 2020

Oxidized low-density lipoprotein and peroxisome-proliferator-activated receptor alpha down-regulate platelet-activating-factor receptor expression in human macrophages

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12 December 2020

Native and oxidized low density lipoprotein induction of tissue factor gene expression in smooth muscle cells is mediated by both Egr-1 and Sp1

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12 December 2020

Antioxidant status in patients with acute respiratory distress syndrome

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12 December 2020

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12 December 2020

Induction of heme oxygenase-1 inhibits the monocyte transmigration induced by mildly oxidized LDL.

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12 December 2020

NF-kappaB: pivotal mediator or innocent bystander in atherogenesis?

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12 December 2020

Temporal increases in plasma markers of oxidized low-density lipoprotein strongly reflect the presence of acute coronary syndromes

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12 December 2020

The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation

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12 December 2020

Hydroxy alkenal phospholipids regulate inflammatory functions of endothelial cells.

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12 December 2020

Oxidative signaling pathway for externalization of plasma membrane phosphatidylserine during apoptosis

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12 December 2020

Epoxyisoprostane and epoxycyclopentenone phospholipids regulate monocyte chemotactic protein-1 and interleukin-8 synthesis. Formation of these oxidized phospholipids in response to interleukin-1beta

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12 December 2020

Phospholipid hydroxyalkenals: biological and chemical properties of specific oxidized lipids present in atherosclerotic lesions.

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12 December 2020

Analysis of inflammatory gene induction by oxidized phospholipids in vivo by quantitative real-time RT-PCR in comparison with effects of LPS.

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12 December 2020

Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

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12 December 2020

Oxidized lipid protects against sepsis

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12 December 2020

Peroxisome proliferator-activated receptor-gamma activators inhibit IFN-gamma-induced expression of the T cell-active CXC chemokines IP-10, Mig, and I-TAC in human endothelial cells

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12 December 2020

Anti-inflammatory properties of a platelet-activating factor acetylhydrolase

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12 December 2020

Oxidized lipids in atherogenesis: formation, destruction and action

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12 December 2020

Oxidized low density lipoprotein suppresses activation of NF kappa B in macrophages via a pertussis toxin-sensitive signaling mechanism

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12 December 2020

Oxysterols and atherosclerosis

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12 December 2020

Pathways of Egr-1-mediated gene transcription in vascular biology

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12 December 2020

Oxidized low density lipoprotein inhibits lipopolysaccharide-induced binding of nuclear factor-kappaB to DNA and the subsequent expression of tumor necrosis factor-alpha and interleukin-1beta in macrophages

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12 December 2020

Oxidative stress and gene expression: the AP-1 and NF-kappaB connections

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12 December 2020

New insights into the role of COX 2 in inflammation.

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12 December 2020

Structural identification by mass spectrometry of oxidized phospholipids in minimally oxidized low density lipoprotein that induce monocyte/endothelial interactions and evidence for their presence in vivo

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12 December 2020

Evidence that phospholipid oxidation products and/or platelet-activating factor play an important role in early atherogenesis : in vitro and In vivo inhibition by WEB 2086.

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12 December 2020

Mitogen-activated protein kinase phosphatase 1 activity is necessary for oxidized phospholipids to induce monocyte chemotactic activity in human aortic endothelial cells

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12 December 2020

Peroxidation of phosphatidylserine in mechanisms of apoptotic signaling

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12 December 2020

Stimulation of Gs and inhibition of Gi protein functions by minimally oxidized LDL

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12 December 2020

Oxidized low density lipoprotein--an extreme example of lipoprotein heterogeneity.

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12 December 2020

Myeloperoxidase functions as a major enzymatic catalyst for initiation of lipid peroxidation at sites of inflammation

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12 December 2020

Minimally modified low density lipoprotein-induced inflammatory responses in endothelial cells are mediated by cyclic adenosine monophosphate

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12 December 2020

The Yin and Yang of oxidation in the development of the fatty streak. A review based on the 1994 George Lyman Duff Memorial Lecture

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12 December 2020

Role of reactive aldehyde in cardiovascular diseases

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12 December 2020

Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between peroxisome proliferator-activated receptor-gamma and nuclear factor-kappa B

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12 December 2020

Induction of IκBα Expression as a Mechanism Contributing to the Anti-inflammatory Activities of Peroxisome Proliferator-activated Receptor-α Activators

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12 December 2020

Oxidized LDL-induced injury and apoptosis in atherosclerosis. Potential roles for oxysterols

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12 December 2020

Rosiglitazone, a peroxisome proliferator-activated receptor-gamma, inhibits the Jun NH(2)-terminal kinase/activating protein 1 pathway and protects the heart from ischemia/reperfusion injury

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12 December 2020

Downregulation by tumor necrosis factor-α of monocyte CCR2 expression and monocyte chemotactic protein-1-induced transendothelial migration is antagonized by oxidized low-density lipoprotein

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12 December 2020

Bioactive oxidized lipids in the plasma of cardiac surgical intensive care patients

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12 December 2020

Expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein

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12 December 2020

Bioactive products of phospholipid oxidation: isolation, identification, measurement and activities

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12 December 2020

The protective effect of serum lipoproteins against bacterial lipopolysaccharide

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12 December 2020

Oxidized membrane vesicles and blebs from apoptotic cells contain biologically active oxidized phospholipids that induce monocyte-endothelial interactions

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12 December 2020

Inhibition of the NF-kappaB transcriptional activity by protein kinase A.

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12 December 2020

cAMP attenuates interleukin-1-stimulated macrophage colony-stimulating factor (M-CSF) expression

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12 December 2020

Peroxisome proliferator-activated receptors in inflammation control

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12 December 2020

Inducible cyclooxygenase may have anti-inflammatory properties

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12 December 2020

The NF-kappa B signal transduction pathway in aortic endothelial cells is primed for activation in regions predisposed to atherosclerotic lesion formation.

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12 December 2020

10.1007/S00109-003-0467-2

Identifiers

DOI

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7 August 2017

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PubMed ID

13679995