The oxidative modification hypothesis of atherogenesis: an overview (Q34006328)

30 July 2017

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title

The oxidative modification hypothesis of atherogenesis: an overview (English)

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30 July 2017

Chisolm GM

1

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PubMed ID

10946223

30 July 2017

Steinberg D

series ordinal

2

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30 July 2017

1 June 2000

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Free Radical Biology and Medicine

30 July 2017

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30 July 2017

28

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30 July 2017

1815-1826

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30 July 2017

12

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LDL-induced cytotoxicity and its inhibition by HDL in human vascular smooth muscle and endothelial cells in culture

30 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Lipoprotein oxidation and lipoprotein-induced cytotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Endothelial and smooth muscle cells alter low density lipoprotein in vitro by free radical oxidation

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Enhanced macrophage degradation of biologically modified low density lipoprotein.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Oxidation and atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Ultraviolet-treated lipoproteins as a model system for the study of the biological effects of lipid peroxides on cultured cells. II. Uptake and cytotoxicity of ultraviolet-treated LDL on lymphoid cell lines.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Glycoxidation and lipoxidation in atherogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Myeloperoxidase-generated oxidants and atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Indices of lipid peroxidation in vivo: strengths and limitations

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Role of reactive aldehyde in cardiovascular diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Bioactive products of phospholipid oxidation: isolation, identification, measurement and activities

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Bioactive phospholipid oxidation products

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Low density lipoprotein undergoes oxidative modification in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Malondialdehyde-altered protein occurs in atheroma of Watanabe heritable hyperlipidemic rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Oxidation-specific epitopes in human coronary atherosclerosis are not limited to oxidized low-density lipoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Characterization of epitopes recognized by 4-hydroxy-2-nonenal specific antibodies

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Immunostaining of human autopsy aortas with antibodies to modified apolipoprotein B and apoprotein(a)

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Macrophage-derived foam cells freshly isolated from rabbit atherosclerotic lesions degrade modified lipoproteins, promote oxidation of low-density lipoproteins, and contain oxidation-specific lipid-protein adducts

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Monoclonal antibodies against oxidized low-density lipoprotein bind to apoptotic cells and inhibit their phagocytosis by elicited macrophages: evidence that oxidation-specific epitopes mediate macrophage recognition

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Structural identification of a novel pro-inflammatory epoxyisoprostane phospholipid in mildly oxidized low density lipoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Apoptosis in human atherosclerosis and restenosis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Immunological responses to oxidized LDL.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Pathogenesis of atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Low density lipoprotein oxidation and its pathobiological significance

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Regulation of cell growth by oxidized LDL.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

The role of natural antioxidants in preserving the biological activity of endothelium-derived nitric oxide

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Modification of human serum low density lipoprotein by oxidation--characterization and pathophysiological implications

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

7 beta-hydroperoxycholest-5-en-3 beta-ol, a component of human atherosclerotic lesions, is the primary cytotoxin of oxidized human low density lipoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Cytotoxicity of oxidized LDL to porcine aortic smooth muscle cells is associated with the oxysterols 7-ketocholesterol and 7-hydroxycholesterol

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

In vitro cell injury by oxidized low density lipoprotein involves lipid hydroperoxide-induced formation of alkoxyl, lipid, and peroxyl radicals

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Characterization and comparison of the mode of cell death, apoptosis versus necrosis, induced by 7beta-hydroxycholesterol and 7-ketocholesterol in the cells of the vascular wall

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Exogenous oxidized low-density lipoprotein injures and alters the barrier function of endothelium in rats in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Arterial injury by cholesterol oxidation products causes endothelial dysfunction and arterial wall cholesterol accumulation

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Lewis A. Conner Memorial Lecture. Oxidative modification of LDL and atherogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Role of oxidized LDL and antioxidants in atherosclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Antioxidants and atherosclerosis. A current assessment

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Antioxidants and atherosclerosis: a current assessment.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Dietary and pharmacological antioxidants in atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Oxidants and antioxidants in the pathogenesis of atherosclerosis: implications for the oxidized low density lipoprotein hypothesis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Antioxidants and atherosclerosis: an overview

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Antioxidants and atherosclerotic heart disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Paradoxical enhancement of atherosclerosis by probucol treatment in apolipoprotein E-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Proatherogenic and antiatherogenic effects of probucol and phytosterols in apolipoprotein E-deficient mice: possible mechanisms of action

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Effect of the antioxidant N,N'-diphenyl 1,4-phenylenediamine (DPPD) on atherosclerosis in apoE-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Dietary antioxidants inhibit development of fatty streak lesions in the LDL receptor-deficient mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Antiatherogenic effects of the antioxidant BO-653 in three different animal models.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Inhibition by a coantioxidant of aortic lipoprotein lipid peroxidation and atherosclerosis in apolipoprotein E and low density lipoprotein receptor gene double knockout mice

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

A comparison of the antiatherogenic effects of probucol and of a structural analogue of probucol in low density lipoprotein receptor-deficient rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Dietary antioxidants preserve endothelium-dependent vessel relaxation in cholesterol-fed rabbits.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Beta-carotene inhibits atherosclerosis in hypercholesterolemic rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Comparative study on the effect of low-dose vitamin E and probucol on the susceptibility of LDL to oxidation and the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Regulation of endothelial adhesion molecules by ligands binding to the scavenger receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

The macrophage scavenger receptor type A is expressed by activated macrophages and protects the host against lethal endotoxic shock

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Scavenger receptor deficiency leads to more complex atherosclerotic lesions in APOE3Leiden transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Scavenging new insights into atherogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

The arachidonate 12/15 lipoxygenases. A review of tissue expression and biologic function

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Lipoxygenases and atherosclerosis: protection versus pathogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

At last, direct evidence that lipoxygenases play a role in atherogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Is there a role for 15-lipoxygenase in atherogenesis?

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Oxidation, lipoxygenase, and atherogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Macrophage-mediated 15-lipoxygenase expression protects against atherosclerosis development

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

The oxidation of lipoproteins by monocytes-macrophages. Biochemical and biological mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

The role of 15-lipoxygenase in atherogenesis: pro- and antiatherogenic actions

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Cell signaling by reactive nitrogen and oxygen species in atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Iron and copper promote modification of low density lipoprotein by human arterial smooth muscle cells in culture

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Macrophage oxidation of low density lipoprotein generates a modified form recognized by the scavenger receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Monocytes and neutrophils oxidize low density lipoprotein making it cytotoxic

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Ceruloplasmin and cardiovascular disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

An animal model to study local oxidation of LDL and its biological effects in the arterial wall.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Oxidation of plasma low-density lipoprotein accelerates its accumulation and degradation in the arterial wall in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Excess iron induces hepatic oxidative stress and transforming growth factor beta1 in genetic hemochromatosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Proteinuria in passive Heymann nephritis is associated with lipid peroxidation and formation of adducts on type IV collagen

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Expression of type I and type II bovine scavenger receptors in Chinese hamster ovary cells: lipid droplet accumulation and nonreciprocal cross competition by acetylated and oxidized low density lipoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Coiled-coil fibrous domains mediate ligand binding by macrophage scavenger receptor type II.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

An endothelial receptor for oxidized low-density lipoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

The 94- to 97-kDa mouse macrophage membrane protein that recognizes oxidized low density lipoprotein and phosphatidylserine-rich liposomes is identical to macrosialin, the mouse homologue of human CD68

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Recognition of solubilized apoproteins from delipidated, oxidized low density lipoprotein (LDL) by the acetyl-LDL receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Receptors for oxidized low-density lipoprotein on elicited mouse peritoneal macrophages can recognize both the modified lipid moieties and the modified protein moieties: implications with respect to macrophage recognition of apoptotic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

The binding of oxidized low density lipoprotein to mouse CD36 is mediated in part by oxidized phospholipids that are associated with both the lipid and protein moieties of the lipoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid-protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Evidence that the lipid moiety of oxidized low density lipoprotein plays a role in its interaction with macrophage receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Clinical trials of antioxidants in atherosclerosis: are we doing the right thing?

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Current perspectives on statins

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Vitamin E consumption and the risk of coronary heart disease in men.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Vitamin E consumption and the risk of coronary disease in women.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Oxysterols and atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Mechanisms of oxidative damage of low density lipoprotein in human atherosclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Autoantibody against oxidised LDL and progression of carotid atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Design of Physicians' Health Study II--a randomized trial of beta-carotene, vitamins E and C, and multivitamins, in prevention of cancer, cardiovascular disease, and eye disease, and review of results of completed trials

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Antioxidants for vascular disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Effect of dietary antioxidant combinations in humans. Protection of LDL by vitamin E but not by beta-carotene.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Vitamin E and heart disease: basic science to clinical intervention trials

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Vitamin E supplementation and cardiovascular events in high-risk patients

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Controlled trial of alpha-tocopherol and beta-carotene supplements on stroke incidence and mortality in male smokers

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

The effect of alpha-tocopherol and beta-carotene supplementation on symptoms and progression of intermittent claudication in a controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Retinal vascular changes following supplementation with alpha-tocopherol or beta-carotene

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

Molecular action of vitamin E in lipoprotein oxidation: implications for atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900344-0

7 January 2021

10.1016/S0891-5849(00)00344-0

Identifiers

DOI

1 reference

30 July 2017

1 reference

PubMed ID

10946223