BRCA1 and p53: compensatory roles in DNA repair (Q35298530)

7 August 2017

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title

BRCA1 and p53: compensatory roles in DNA repair (English)

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7 August 2017

2

James M Ford

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7 August 2017

Anne-Renee Hartman

1

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7 August 2017

publication date

9 September 2003

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Journal of Molecular Medicine

7 August 2017

published in

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7 August 2017

volume

81

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7 August 2017

issue

11

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7 August 2017

page(s)

700-707

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Role of DNA excision repair gene defects in the etiology of cancer.

7 August 2017

cites work

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12 December 2020

BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression

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12 December 2020

Familial invasive breast cancers: worse outcome related to BRCA1 mutations

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12 December 2020

p53 and DNA damage-inducible expression of the xeroderma pigmentosum group C gene

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12 December 2020

p53 responsive nucleotide excision repair gene products p48 and XPC, but not p53, localize to sites of UV-irradiation-induced DNA damage, in vivo

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12 December 2020

Loss of heterozygosity of nucleotide excision repair factors in sporadic ovarian, colon and lung carcinomas: implication for their roles of carcinogenesis in human solid tumors

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12 December 2020

BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a brca1 transgene.

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12 December 2020

Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

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12 December 2020

Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity

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12 December 2020

Genetic analysis of BRCA1 function in a defined tumor cell line

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12 December 2020

Fanconi anemia and DNA repair

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12 December 2020

Tumour-specific distribution of BRCA1 promoter region methylation supports a pathogenetic role in breast and ovarian cancer

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12 December 2020

BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repair.

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12 December 2020

p53 mutation with frequent novel condons but not a mutator phenotype in BRCA1- and BRCA2-associated breast tumours

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12 December 2020

Germline BRCA1/2 mutations and p27(Kip1) protein levels independently predict outcome after breast cancer.

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12 December 2020

Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors

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12 December 2020

The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation

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12 December 2020

Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts.

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12 December 2020

Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice

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12 December 2020

Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation.

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12 December 2020

Deficient gene specific repair of cisplatin-induced lesions in Xeroderma pigmentosum and Fanconi's anemia cell lines

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12 December 2020

p53-dependent global genomic repair of benzo[a]pyrene-7,8-diol-9,10-epoxide adducts in human cells

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12 December 2020

Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway

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12 December 2020

Regulation of BRCA1 and BRCA2 transcript in response to cisplatin, adriamycin, taxol and ionising radiation is correlated to p53 functional status in ovarian cancer cell lines

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12 December 2020

DNA damage recognition during nucleotide excision repair in mammalian cells

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12 December 2020

The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse

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12 December 2020

Brca1 controls homology-directed DNA repair

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12 December 2020

The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway

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12 December 2020

BRCA1 required for transcription-coupled repair of oxidative DNA damage

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12 December 2020

Promoter hypermethylation and post-transcriptional mechanisms for reduced BRCA1 immunoreactivity in sporadic human breast cancers.

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12 December 2020

Knockout mouse models and mammary tumorigenesis

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12 December 2020

Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2.

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12 December 2020

p53 and regulation of DNA damage recognition during nucleotide excision repair

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12 December 2020

The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression

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12 December 2020

Single nucleotide polymorphisms in theXPGgene: Determination of role in DNA repair and breast cancer risk

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12 December 2020

BRCA1 transcriptionally regulates damaged DNA binding protein (DDB2) in the DNA repair response following UV-irradiation.

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12 December 2020

Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair

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12 December 2020

Expression of wild-type p53 is required for efficient global genomic nucleotide excision repair in UV-irradiated human fibroblasts

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12 December 2020

Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage

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12 December 2020

TP53 mutations in breast cancer associated with BRCA1 or BRCA2 germ-line mutations: distinctive spectrum and structural distribution.

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12 December 2020

Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1.

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12 December 2020

BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function

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12 December 2020

p53-mediated DNA repair responses to UV radiation: studies of mouse cells lacking p53, p21, and/or gadd45 genes

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12 December 2020

BRCA1 supports XIST RNA concentration on the inactive X chromosome

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12 December 2020

Is TP53 dysfunction required for BRCA1-associated carcinogenesis?

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12 December 2020

BRCA1 activation of the GADD45 promoter.

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12 December 2020

The p53-regulated cyclin-dependent kinase inhibitor, p21 (cip1, waf1, sdi1), is not required for global genomic and transcription-coupled nucleotide excision repair of UV-induced DNA photoproducts

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12 December 2020

Participation of p53 protein in the cellular response to DNA damage

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12 December 2020

Sensitivity to benzo(a)pyrene diol-epoxide associated with risk of breast cancer in young women and modulation by glutathione S-transferase polymorphisms: a case-control study.

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12 December 2020

Absence of major defects in non-homologous DNA end joining in human breast cancer cell lines

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12 December 2020

hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

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12 December 2020

Homology-directed dna repair, mitomycin-c resistance, and chromosome stability is restored with correction of a Brca1 mutation

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12 December 2020

The pathology of familial breast cancer: predictive value of immunohistochemical markers estrogen receptor, progesterone receptor, HER-2, and p53 in patients with mutations in BRCA1 and BRCA2.

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12 December 2020

Effect of Radiotherapy After Breast-Conserving Treatment in Women With Breast Cancer and Germline BRCA1/2 Mutations

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12 December 2020

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures

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12 December 2020

BRCA1 and BRCA2 are necessary for the transcription-coupled repair of the oxidative 8-oxoguanine lesion in human cells.

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12 December 2020

BRCA1 expression restores radiation resistance in BRCA1-defective cancer cells through enhancement of transcription-coupled DNA repair

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12 December 2020

Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance

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12 December 2020

BRCA1 up-regulation is associated with repair-mediated resistance to cis-diamminedichloroplatinum(II).

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12 December 2020

Loss of heterozygosity of nucleotide excision repair factors in sporadic oral squamous cell carcinoma using microdissected tissue

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12 December 2020

Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response

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12 December 2020

BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor

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12 December 2020

Methylation of the BRCA1 promoter is associated with decreased BRCA1 mRNA levels in clinical breast cancer specimens

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12 December 2020

Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor

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12 December 2020

Immunoperoxidase detection of polycyclic aromatic hydrocarbon-DNA adducts in breast tissue sections

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12 December 2020

Human fibroblasts expressing the human papillomavirus E6 gene are deficient in global genomic nucleotide excision repair and sensitive to ultraviolet irradiation

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12 December 2020

Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1

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12 December 2020

Gene-Expression Profiles in Hereditary Breast Cancer

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12 December 2020

Polymorphisms in the DNA repair enzyme XPD are associated with increased levels of PAH-DNA adducts in a case-control study of breast cancer

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12 December 2020

The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin

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12 December 2020

Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response

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12 December 2020

Tumor suppressor p53 is required to modulate BRCA1 expression

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12 December 2020

Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation

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12 December 2020

p53 modulation of TFIIH-associated nucleotide excision repair activity

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12 December 2020

Growth retardation, DNA repair defects, and lack of spermatogenesis in BRCA1-deficient mice

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12 December 2020

Nucleotide excision repair in mammalian cells

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12 December 2020

Risks of cancer in BRCA1-mutation carriers. Breast Cancer Linkage Consortium

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12 December 2020

10.1007/S00109-003-0477-0

Identifiers

DOI

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7 August 2017

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