Repeat-associated non-AUG translation and its impact in neurodegenerative disease (Q35340115)

7 August 2017

title

Repeat-associated non-AUG translation and its impact in neurodegenerative disease (English)

1 reference

7 August 2017

1 reference

Michael G Kearse

1

1 reference

7 August 2017

Peter K Todd

series ordinal

2

1 reference

7 August 2017

publication date

1 October 2014

1 reference

7 August 2017

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7 August 2017

volume

11

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7 August 2017

issue

4

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7 August 2017

page(s)

721-731

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Initiation of Translation by Cricket Paralysis Virus IRES Requires Its Translocation in the Ribosome

7 August 2017

cites work

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RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia

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Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion

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RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention

27 July 2018

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Antisense transcripts of the expanded C9ORF72 hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-ATG translation in c9FTD/ALS

27 July 2018

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Direct detection of alternative open reading frames translation products in human significantly expands the proteome

27 July 2018

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Repeat-associated non-ATG (RAN) translation in neurological disease

27 July 2018

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27 July 2018

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Trinucleotide repeats: a structural perspective

27 July 2018

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CGG repeat-associated translation mediates neurodegeneration in fragile X tremor ataxia syndrome

27 July 2018

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Unconventional translation of C9ORF72 GGGGCC expansion generates insoluble polypeptides specific to c9FTD/ALS

27 July 2018

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Impaired activity-dependent FMRP translation and enhanced mGluR-dependent LTD in Fragile X premutation mice

27 July 2018

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Landscape of transcription in human cells

27 July 2018

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27 July 2018

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27 July 2018

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Muscleblind-like 2-mediated alternative splicing in the developing brain and dysregulation in myotonic dystrophy

27 July 2018

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Genome-wide search for novel human uORFs and N-terminal protein extensions using ribosomal footprinting

27 July 2018

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The mechanism of eukaryotic translation initiation: new insights and challenges

27 July 2018

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A mechanistic overview of translation initiation in eukaryotes

27 July 2018

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Observation of dually decoded regions of the human genome using ribosome profiling data

27 July 2018

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27 July 2018

The N-end rule pathway

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The pathophysiology of fragile X (and what it teaches us about synapses)

27 July 2018

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Nuclear translation visualized by ribosome-bound nascent chain puromycylation.

27 July 2018

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Dephosphorylation-induced ubiquitination and degradation of FMRP in dendrites: a role in immediate early mGluR-stimulated translation

27 July 2018

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5'-UTR RNA G-quadruplexes: translation regulation and targeting

27 July 2018

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High-resolution view of the yeast meiotic program revealed by ribosome profiling

27 July 2018

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Repetitive elements may comprise over two-thirds of the human genome

27 July 2018

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Neurodegeneration the RNA way

27 July 2018

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Ribosome profiling of mouse embryonic stem cells reveals the complexity and dynamics of mammalian proteomes

27 July 2018

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A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

27 July 2018

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Molecular mechanism of scanning and start codon selection in eukaryotes

27 July 2018

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FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism

27 July 2018

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The N-end rule pathway: from recognition by N-recognins, to destruction by AAA+proteases.

27 July 2018

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eIF2A mediates translation of hepatitis C viral mRNA under stress conditions

27 July 2018

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Differential usage of transcriptional start sites and polyadenylation sites in FMR1 premutation alleles.

27 July 2018

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A non-canonical start codon in the Drosophila fragile X gene yields two functional isoforms

27 July 2018

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Identification of evolutionarily conserved non-AUG-initiated N-terminal extensions in human coding sequences

27 July 2018

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Initiation of translation of the FMR1 mRNA Occurs predominantly through 5'-end-dependent ribosomal scanning

27 July 2018

1 reference

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Non-ATG-initiated translation directed by microsatellite expansions

27 July 2018

1 reference

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Activities of Ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling

27 July 2018

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The pioneer round of translation: features and functions

27 July 2018

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GTP-independent tRNA delivery to the ribosomal P-site by a novel eukaryotic translation factor

27 July 2018

1 reference

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Mutations in Caenorhabditis elegans eIF2beta permit translation initiation from non-AUG start codons

27 July 2018

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Sam68 sequestration and partial loss of function are associated with splicing alterations in FXTAS patients

27 July 2018

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RNA gain-of-function in spinocerebellar ataxia type 8.

27 July 2018

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Role of 5'- and 3'-untranslated regions of mRNAs in human diseases

27 July 2018

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The quadruplex r(CGG)n destabilizing cationic porphyrin TMPyP4 cooperates with hnRNPs to increase the translation efficiency of fragile X premutation mRNA

27 July 2018

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27 July 2018

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Mechanisms of RNA-mediated disease.

27 July 2018

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Identifying intrinsic and extrinsic determinants that regulate internal initiation of translation mediated by the FMR1 5' leader

27 July 2018

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27 July 2018

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Eukaryotic translation initiation machinery can operate in a bacterial-like mode without eIF2.

27 July 2018

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27 July 2018

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eIF2-dependent and eIF2-independent modes of initiation on the CSFV IRES: a common role of domain II

27 July 2018

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The tetraplex (CGG)n destabilizing proteins hnRNP A2 and CBF-A enhance the in vivo translation of fragile X premutation mRNA.

27 July 2018

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Pur alpha binds to rCGG repeats and modulates repeat-mediated neurodegeneration in a Drosophila model of fragile X tremor/ataxia syndrome.

27 July 2018

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27 July 2018

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Trinucleotide Repeat Disorders

27 July 2018

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Reversal of RNA missplicing and myotonia after muscleblind overexpression in a mouse poly(CUG) model for myotonic dystrophy

27 July 2018

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Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

27 July 2018

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Position of the CrPV IRES on the 40S subunit and factor dependence of IRES/80S ribosome assembly

27 July 2018

1 reference

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Destabilization of tetraplex structures of the fragile X repeat sequence (CGG)n is mediated by homolog-conserved domains in three members of the hnRNP family

27 July 2018

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A muscleblind knockout model for myotonic dystrophy

27 July 2018

1 reference

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The fragile X syndrome repeats form RNA hairpins that do not activate the interferon-inducible protein kinase, PKR, but are cut by Dicer

27 July 2018

1 reference

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Initiator Met-tRNA-independent translation mediated by an internal ribosome entry site element in cricket paralysis virus-like insect viruses

27 July 2018

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X-Ray structures of the universal translation initiation factor IF2/eIF5B: conformational changes on GDP and GTP binding

27 July 2018

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Recruitment of human muscleblind proteins to (CUG)(n) expansions associated with myotonic dystrophy

27 July 2018

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Initiation of Apaf-1 translation by internal ribosome entry

27 July 2018

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An untranslated CTG expansion causes a novel form of spinocerebellar ataxia (SCA8)

27 July 2018

1 reference

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Cap-independent polysomal association of natural mRNAs encoding c-myc, BiP, and eIF4G conferred by internal ribosome entry sites

27 July 2018

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Promotion of met-tRNAiMet binding to ribosomes by yIF2, a bacterial IF2 homolog in yeast

27 July 2018

1 reference

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A prokaryotic-like mode of cytoplasmic eukaryotic ribosome binding to the initiation codon during internal translation initiation of hepatitis C and classical swine fever virus RNAs

27 July 2018

1 reference

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GTP hydrolysis controls stringent selection of the AUG start codon during translation initiation in Saccharomyces cerevisiae

27 July 2018

1 reference

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Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation

27 July 2018

1 reference

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Functional dissection of eukaryotic initiation factor 4F: the 4A subunit and the central domain of the 4G subunit are sufficient to mediate internal entry of 43S preinitiation complexes

27 July 2018

1 reference

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Canonical eukaryotic initiation factors determine initiation of translation by internal ribosomal entry

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Internal initiation of translation of hepatitis C virus RNA: the ribosome entry site is at the authentic initiation codon

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Internal initiation of translation directed by the 5'-untranslated region of the mRNA for eIF4G, a factor involved in the picornavirus-induced switch from cap-dependent to internal initiation

27 July 2018

1 reference

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

27 July 2018

1 reference

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Alternative translation of human fibroblast growth factor 2 mRNA occurs by internal entry of ribosomes

27 July 2018

1 reference

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Translation of the genome of a ribonucleic acid bacteriophage

27 July 2018

1 reference

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Influences of mRNA secondary structure on initiation by eukaryotic ribosomes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Mutations at a Zn(II) finger motif in the yeast eIF-2 beta gene alter ribosomal start-site selection during the scanning process

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

In vivo half-life of a protein is a function of its amino-terminal residue

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Insertion mutagenesis to increase secondary structure within the 5' noncoding region of a eukaryotic mRNA reduces translational efficiency.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Yeast translation initiation suppressor sui2 encodes the alpha subunit of eukaryotic initiation factor 2 and shares sequence identity with the human alpha subunit.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Circumstances and mechanisms of inhibition of translation by secondary structure in eucaryotic mRNAs

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Context effects and inefficient initiation at non-AUG codons in eucaryotic cell-free translation systems

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Universality and structure of the N-end rule

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Downstream secondary structure facilitates recognition of initiator codons by eukaryotic ribosomes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Structural features in eukaryotic mRNAs that modulate the initiation of translation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

The suil suppressor locus in Saccharomyces cerevisiae encodes a translation factor that functions during tRNA(iMet) recognition of the start codon

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Mechanisms of toxicity in C9FTLD/ALS.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Sequestration of DROSHA and DGCR8 by expanded CGG RNA repeats alters microRNA processing in fragile X-associated tremor/ataxia syndrome.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Repeat associated non-ATG translation initiation: one DNA, two transcripts, seven reading frames, potentially nine toxic entities!

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

The role of eIF1 in translation initiation codon selection in Caenorhabditis elegans

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Identification of novel FMR1 variants by massively parallel sequencing in developmentally delayed males

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Aberrant alternative splicing and extracellular matrix gene expression in mouse models of myotonic dystrophy.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

The mechanism of eukaryotic translation initiation and principles of its regulation

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Transcriptional and post-transcriptional impact of toxic RNA in myotonic dystrophy

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Secondary structure and dynamics of the r(CGG) repeat in the mRNA of the fragile X mental retardation 1 (FMR1) gene

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

RNA-binding proteins hnRNP A2/B1 and CUGBP1 suppress fragile X CGG premutation repeat-induced neurodegeneration in a Drosophila model of FXTAS.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Dynamic translational and proteasomal regulation of fragile X mental retardation protein controls mGluR-dependent long-term depression

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Bidirectional expression of CUG and CAG expansion transcripts and intranuclear polyglutamine inclusions in spinocerebellar ataxia type 8.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Two internal ribosome entry sites mediate the translation of p53 isoforms.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Antisense transcription and heterochromatin at the DM1 CTG repeats are constrained by CTCF.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Protein composition of the intranuclear inclusions of FXTAS.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Redistribution of transcription start sites within the FMR1 promoter region with expansion of the downstream CGG-repeat element

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Translation elongation after assembly of ribosomes on the Cricket paralysis virus internal ribosomal entry site without initiation factors or initiator tRNA.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Distinct domains in the CArG-box binding factor A destabilize tetraplex forms of the fragile X expanded sequence d(CGG)n

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

The 5'-untranslated region of the FMR1 message facilitates translation by internal ribosome entry.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Initiation of protein synthesis from the A site of the ribosome

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

NGG-triplet repeats form similar intrastrand structures: implications for the triplet expansion diseases

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Features in the 5' non-coding sequences of rabbit alpha and beta-globin mRNAs that affect translational efficiency

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Translational suppression by trinucleotide repeat expansion at FMR1.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4391382

Specific dephosphorylation of the Lck tyrosine protein kinase at Tyr-394 by the SHP-1 protein-tyrosine phosphatase

26 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS13311-014-0292-Z

Myotonic dystrophy in transgenic mice expressing an expanded CUG repeat

21 January 2018

1 reference

12 December 2020

Effect of CAT or AGG interruptions and CpG methylation on nucleosome assembly upon trinucleotide repeats on spinocerebellar ataxia, type 1 and fragile X syndrome

1 reference

12 December 2020

Long CCG triplet repeat blocks exclude nucleosomes: a possible mechanism for the nature of fragile sites in chromosomes

1 reference

12 December 2020

Adherence to the first-AUG rule when a second AUG codon follows closely upon the first

1 reference

12 December 2020

Purification and characterization of homogeneous protein synthesis initiation factor M1 from rabbit reticulocytes

1 reference

12 December 2020

10.1007/S13311-014-0292-Z

Identifiers

DOI

1 reference

7 August 2017

1 reference

7 August 2017

1 reference