GxxxG motifs, phenylalanine, and cholesterol guide the self-association of transmembrane domains of ErbB2 receptors (Q35342149)

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English	GxxxG motifs, phenylalanine, and cholesterol guide the self-association of transmembrane domains of ErbB2 receptors	scientific article

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14 January 2020

GxxxG motifs, phenylalanine, and cholesterol guide the self-association of transmembrane domains of ErbB2 receptors (English)

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14 January 2020

transmembrane protein

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Manolis Doxastakis

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14 January 2020

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Anupam Prakash

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14 January 2020

Lorant Janosi

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1 October 2011

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14 January 2020

Biophysical Journal

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14 January 2020

1949-1958

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14 January 2020

GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

12 July 2018

Lipid Models for United-Atom Molecular Dynamics Simulations of Proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

12 July 2018

The extracellular domain of fibroblast growth factor receptor 3 inhibits ligand-independent dimerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

12 July 2018

Self-association of models of transmembrane domains of ErbB receptors in a lipid bilayer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

12 July 2018

Molecular simulation of the effect of cholesterol on lipid-mediated protein-protein interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

12 July 2018

Structural Evidence for Loose Linkage between Ligand Binding and Kinase Activation in the Epidermal Growth Factor Receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

12 July 2018

Lipid-modulated sequence-specific association of glycophorin A in membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

12 July 2018

A molecular view of the cholesterol condensing effect in DOPC lipid bilayers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

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Spatial control of EGF receptor activation by reversible dimerization on living cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

12 July 2018

Measuring the energetics of membrane protein dimerization in mammalian membranes

1 reference

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Transmembrane helix association affinity can be modulated by flanking and noninterfacial residues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

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Using two fluorescent probes to dissect the binding, insertion, and dimerization kinetics of a model membrane peptide

1 reference

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12 July 2018

Fundamental aspects of protein-protein association kinetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

12 July 2018

Helix-helix interactions in membrane proteins: coarse-grained simulations of glycophorin a helix dimerization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

12 July 2018

All EGF(ErbB) receptors have preformed homo- and heterodimeric structures in living cells.

1 reference

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12 July 2018

Protein-protein interactions in the membrane: sequence, structural, and biological motifs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

12 July 2018

Association energetics of membrane spanning alpha-helices

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

12 July 2018

Finding transition pathways using the string method with swarms of trajectories

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

12 July 2018

Spatial structure of the dimeric transmembrane domain of the growth factor receptor ErbB2 presumably corresponding to the receptor active state

1 reference

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12 July 2018

Dynamic equilibrium between multiple active and inactive conformations explains regulation and oncogenic mutations in ErbB receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

12 July 2018

Phenylalanine promotes interaction of transmembrane domains via GxxxG motifs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

12 July 2018

Investigation of the dimerization of proteins from the epidermal growth factor receptor family by single wavelength fluorescence cross-correlation spectroscopy

1 reference

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12 July 2018

Role of receptor tyrosine kinase transmembrane domains in cell signaling and human pathologies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

12 July 2018

Insertion and assembly of membrane proteins via simulation.

1 reference

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12 July 2018

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1 reference

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Inhibition by transmembrane peptides of chimeric insulin receptors

1 reference

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Growth factor receptors, lipid rafts and caveolae: an evolving story

1 reference

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12 July 2018

Cholesterol dictates the freedom of EGF receptors and HER2 in the plane of the membrane

1 reference

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12 July 2018

Transmembrane peptides as inhibitors of ErbB receptor signaling

1 reference

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12 July 2018

The tethered configuration of the EGF receptor extracellular domain exerts only a limited control of receptor function

1 reference

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12 July 2018

Cholesterol depletion results in site-specific increases in epidermal growth factor receptor phosphorylation due to membrane level effects. Studies with cholesterol enantiomers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

12 July 2018

An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

12 July 2018

A putative molecular-activation switch in the transmembrane domain of erbB2.

1 reference

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12 July 2018

Cholesterol levels modulate EGF receptor-mediated signaling by altering receptor function and trafficking

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

12 July 2018

Transition path sampling: throwing ropes over rough mountain passes, in the dark.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

12 July 2018

Efficient, Multiple-Range Random Walk Algorithm to Calculate the Density of States

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

12 July 2018

Combined Monte Carlo and molecular dynamics simulation of hydrated lipid-cholesterol lipid bilayers at low cholesterol concentration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

12 July 2018

Rotational coupling of the transmembrane and kinase domains of the Neu receptor tyrosine kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

12 July 2018

The GxxxG motif: a framework for transmembrane helix-helix association

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

12 July 2018

The dimerization motif of the glycophorin A transmembrane segment in membranes: importance of glycine residues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

12 July 2018

A transmembrane helix dimer: structure and implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

12 July 2018

VMD: visual molecular dynamics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

12 July 2018

Helix to helix packing in proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

12 July 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

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Sequence-dependent oligomerization of the Neu transmembrane domain suggests inhibition of "conformational switching" by an oncogenic mutant

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

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Two GxxxG-like motifs facilitate promiscuous interactions of the human ErbB transmembrane domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

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Computational design of peptides that target transmembrane helices.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

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Insights into the recognition and association of transmembrane alpha-helices. The free energy of alpha-helix dimerization in glycophorin A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

26 September 2018

Complex interactions at the helix-helix interface stabilize the glycophorin A transmembrane dimer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

26 September 2018

Molecular dynamics simulations of the transmembrane domain of the oncogenic ErbB2 receptor dimer in a DMPC bilayer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

26 September 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

26 September 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

26 September 2018

The single transmembrane domains of ErbB receptors self-associate in cell membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

26 September 2018

Self-association of model transmembrane alpha-helices is modulated by lipid structure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

26 September 2018

Dimer interface of transmembrane domains for neu/erbB-2 receptor dimerization and transforming activation: a model revealed by molecular dynamics simulations

1 reference

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26 September 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

26 September 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

26 September 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192960

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1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/22004749

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential of mean force between a spherical particle suspended in a nematic liquid crystal and a substrate: sphere size effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/22004749

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/22004749

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane protein folding and oligomerization: the two-stage model

1 reference

https://pubmed.ncbi.nlm.nih.gov/22004749

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neu receptor dimerization

1 reference

https://pubmed.ncbi.nlm.nih.gov/22004749

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A dimerization motif for transmembrane α–helices

1 reference

https://pubmed.ncbi.nlm.nih.gov/22004749

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

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based on heuristic

inferred from PubMed ID database lookup

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10.1016/J.BPJ.2011.09.017

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14 January 2020

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14 January 2020

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14 January 2020

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