CD4 and MHC class 1 down-modulation activities of nef alleles from brain- and lymphoid tissue-derived primary HIV-1 isolates (Q35400103)

8 August 2017

CD4 and MHC class 1 down-modulation activities of nef alleles from brain- and lymphoid tissue-derived primary HIV-1 isolates (English)

1 reference

8 August 2017

Lachlan R Gray

1

0 references

Steven L Wesselingh

6

object named as

Steven L Wesselingh

1 reference

8 August 2017

2

Dana Gabuzda

1 reference

8 August 2017

Daniel Cowley

3

1 reference

8 August 2017

Anne Ellett

4

1 reference

8 August 2017

Lisa Chiavaroli

5

1 reference

8 August 2017

Melissa J Churchill

7

1 reference

8 August 2017

Paul R Gorry

8

1 reference

8 August 2017

language of work or name

1 reference

30 November 2010

1 reference

8 August 2017

Journal of NeuroVirology

1 reference

8 August 2017

17

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8 August 2017

1

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8 August 2017

82-91

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https://scigraph.springernature.com/pub.10.1007/s13365-010-0001-6

8 August 2017

0 references

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Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementia

27 July 2018

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Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo

27 July 2018

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Phenotype and envelope gene diversity of nef-deleted HIV-1 isolated from long-term survivors infected from a single source

27 July 2018

1 reference

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CD4 and MHC-I downregulation are conserved in primary HIV-1 Nef alleles from brain and lymphoid tissues, but Pak2 activation is highly variable

27 July 2018

1 reference

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Use of laser capture microdissection to detect integrated HIV-1 DNA in macrophages and astrocytes from autopsy brain tissues

27 July 2018

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A hydrophobic binding surface on the human immunodeficiency virus type 1 Nef core is critical for association with p21-activated kinase 2.

27 July 2018

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The neuropathogenesis of AIDS

27 July 2018

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Human immunodeficiency virus type 1 Nef protein mediates neural cell death: a neurotoxic role for IP-10.

27 July 2018

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The physiological relevance of CD4 receptor down-modulation during HIV infection

27 July 2018

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Decreased neurotropism of nef long terminal repeat (nef/LTR)-deleted simian immunodeficiency virus

27 July 2018

1 reference

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Structure--function relationships in HIV-1 Nef.

27 July 2018

1 reference

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HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell

27 July 2018

1 reference

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The plasma membrane as a combat zone in the HIV battlefield

27 July 2018

1 reference

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HIV accessory proteins: multifunctional components of a complex system.

27 July 2018

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HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes

27 July 2018

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Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes

27 July 2018

1 reference

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Diminished production of human immunodeficiency virus type 1 in astrocytes results from inefficient translation of gag, env, and nef mRNAs despite efficient expression of Tat and Rev

27 July 2018

1 reference

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A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4

27 July 2018

1 reference

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A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor

27 July 2018

1 reference

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Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity

27 July 2018

1 reference

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Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1.

27 July 2018

1 reference

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Infectivity enhancement by HIV-1 Nef is dependent on the pathway of virus entry: implications for HIV-based gene transfer systems

27 July 2018

1 reference

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Pseudotyping human immunodeficiency virus type 1 (HIV-1) by the glycoprotein of vesicular stomatitis virus targets HIV-1 entry to an endocytic pathway and suppresses both the requirement for Nef and the sensitivity to cyclosporin A.

27 July 2018

1 reference

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Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms.

27 July 2018

1 reference

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Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

27 July 2018

1 reference

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Molecular characterization of human immunodeficiency virus type 1 cloned directly from uncultured human brain tissue: identification of replication-competent and -defective viral genomes

27 July 2018

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An infectious molecular clone of an unusual macrophage-tropic and highly cytopathic strain of human immunodeficiency virus type 1

27 July 2018

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CNS immune privilege: hiding in plain sight

27 July 2018

1 reference

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Transcriptional activity of blood-and cerebrospinal fluid-derived nef/long-terminal repeat sequences isolated from a slow progressor infected with nef-deleted human immunodeficiency virus type 1 (HIV-1) who developed HIV-associated dementia

21 January 2018

1 reference

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HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.

21 January 2018

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Live and let die: Nef functions beyond HIV replication

21 January 2018

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Macrophage tropism of human immunodeficiency virus type 1 isolates from brain and lymphoid tissues predicts neurotropism independent of coreceptor specificity

21 January 2018

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Increased CCR5 affinity and reduced CCR5/CD4 dependence of a neurovirulent primary human immunodeficiency virus type 1 isolate.

21 January 2018

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Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner

21 January 2018

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Macrophage entry mediated by HIV Envs from brain and lymphoid tissues is determined by the capacity to use low CD4 levels and overall efficiency of fusion.

21 January 2018

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Producer cell-dependent requirement of the Nef protein for efficient entry of HIV-1 into cells

21 January 2018

1 reference

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Replication-dependent pathogenicity of attenuated nef-deleted HIV-1 in vivo

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21165790

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Longitudinal Analysis ofnef/Long Terminal Repeat–Deleted HIV‐1 in Blood and Cerebrospinal Fluid of a Long‐Term Survivor Who Developed HIV‐Associated Dementia

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21165790

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S13365-010-0001-6

1 reference

8 August 2017

1 reference

8 August 2017

1 reference