XRCC1 suppresses somatic hypermutation and promotes alternative nonhomologous end joining in Igh genes (Q35441496)

8 August 2017

XRCC1 suppresses somatic hypermutation and promotes alternative nonhomologous end joining in Igh genes (English)

1 reference

8 August 2017

Huseyin Saribasak

1

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Robert W. Maul

object named as

Robert W Maul

2

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author name string

Zheng Cao

3

1 reference

8 August 2017

Rhonda L McClure

4

1 reference

8 August 2017

William Yang

5

1 reference

8 August 2017

Daniel R McNeill

6

1 reference

8 August 2017

David M Wilson

7

1 reference

8 August 2017

Patricia J Gearhart

8

1 reference

8 August 2017

language of work or name

English

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publication date

3 October 2011

1 reference

Journal of Experimental Medicine

8 August 2017

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8 August 2017

208

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8 August 2017

11

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8 August 2017

2209-2216

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XRCC1 haploinsufficiency in mice has little effect on aging, but adversely modifies exposure-dependent susceptibility

8 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201205

Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201205

CtIP promotes microhomology-mediated alternative end joining during class-switch recombination

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201205

MSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sites

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201205

AID and somatic hypermutation.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201205

Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4-ligase IV during chromosomal translocation formation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201205

Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201205

Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201205

Multiple functions of MRN in end-joining pathways during isotype class switching

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201205

S region sequence, RNA polymerase II, and histone modifications create chromatin accessibility during class switch recombination

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201205

Immunoglobulin switch mu sequence causes RNA polymerase II accumulation and reduces dA hypermutation.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201205

Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201205

IgH class switching and translocations use a robust non-classical end-joining pathway

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201205

Role for DNA repair factor XRCC4 in immunoglobulin class switch recombination.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201205

DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201205

Antibody class switching mediated by yeast endonuclease-generated DNA breaks.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201205

Down-regulation of DNA polymerase beta accompanies somatic hypermutation in human BL2 cell lines

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201205

The mechanics of base excision repair, and its relationship to aging and disease

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201205

Early embryonic lethality due to targeted inactivation of DNA ligase III

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201205

SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201205

Uracil DNA glycosylase disruption blocks Ig gene conversion and induces transition mutations

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201205

Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversification

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201205

DNA ligase III as a candidate component of backup pathways of nonhomologous end joining

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201205

Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201205

XRCC1 and DNA strand break repair

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201205

Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201205

Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201205

Breaksite batch mapping, a rapid method for assay and identification of DNA breaksites in mammalian cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201205

Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining.

27 July 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20111135

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20111135

APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20111135

Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20111135

CHIP-mediated degradation and DNA damage-dependent stabilization regulate base excision repair proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20111135

AID is required for c-myc/IgH chromosome translocations in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20111135

Somatic hypermutation: processivity of the cytosine deaminase AID and error-free repair of the resulting uracils

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20111135

Requirement for the Xrcc1 DNA base excision repair gene during early mouse development

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20111135

21 January 2018

Identifiers

DOI

10.1084/JEM.20111135

1 reference

8 August 2017

1 reference

8 August 2017

1 reference