Preclinical study of treatment response in HCT-116 cells and xenografts with (1) H-decoupled (31) P MRS. (Q35445919)

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14 February 2020

title

Preclinical study of treatment response in HCT-116 cells and xenografts with (1) H-decoupled (31) P MRS (English)

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14 February 2020

1 reference

1

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14 February 2020

Ellen Ackerstaff

5

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14 February 2020

Samuel Singer

10

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14 February 2020

author name string

Peter T Kennealey

2

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14 February 2020

H Carl Le

3

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14 February 2020

Kristen L Zakian

4

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14 February 2020

Asif Rizwan

6

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14 February 2020

Jin-Hong Chen

7

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14 February 2020

Elliot B Sambol

8

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14 February 2020

Gary K Schwartz

9

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14 February 2020

Jason A Koutcher

11

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publication date

24 March 2011

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14 February 2020

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14 February 2020

volume

24

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issue

9

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14 February 2020

page(s)

1159-1168

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Tumor cell metabolism imaging

14 February 2020

cites work

1 reference

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Therapeutic targets and biomarkers identified in cancer choline phospholipid metabolism

12 July 2018

1 reference

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Choline phospholipid metabolism: a target in cancer cells?

12 July 2018

1 reference

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Phosphatidylcholine and cell death

12 July 2018

1 reference

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Biochemical correlates of thiazolidinedione-induced adipocyte differentiation by high-resolution magic angle spinning NMR spectroscopy

12 July 2018

1 reference

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Regulation of choline kinase activity by Ras proteins involves Ral-GDS and PI3K

12 July 2018

1 reference

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Mechanisms of action of flavopiridol

12 July 2018

1 reference

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Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia.

12 July 2018

1 reference

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Phospholipid biosynthesis in the yeast Saccharomyces cerevisiae and interrelationship with other metabolic processes

12 July 2018

1 reference

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Tumour phospholipid metabolism

12 July 2018

1 reference

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Interactions among pathways for phosphatidylcholine metabolism, CTP synthesis and secretion through the Golgi apparatus

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201722

Impact of oncogenes in tumor angiogenesis: mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells

12 July 2018

1 reference

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Choline kinase inhibitors as a novel approach for antiproliferative drug design

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201722

Quantitative neuropathology by high resolution magic angle spinning proton magnetic resonance spectroscopy

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201722

Flavopiridol: a cytotoxic flavone that induces cell death in noncycling A549 human lung carcinoma cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201722

Choline deficiency induces apoptosis in SV40-immortalized CWSV-1 rat hepatocytes in culture

12 July 2018

1 reference

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Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201722

Eukaryotic phospholipid biosynthesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201722

The end of the (cell) line: methods for the study of apoptosis in vitro.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201722

Observations on the phosphate status and intracellular pH of intact cells, protoplasts and chloroplasts from photosynthetic tissue using phosphorus-31 nuclear magnetic resonance.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201722

Regulation of phosphatidylcholine biosynthesis.

12 July 2018

1 reference

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Tumor measurement in the nude mouse

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201722

A phase I clinical trial of the sequential combination of irinotecan followed by flavopiridol

12 July 2018

1 reference

Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models

21 January 2018

1 reference

Choline deficiency induces apoptosis in primary cultures of fetal neurons

21 January 2018

1 reference

Phosphorylation of Saccharomyces cerevisiae choline kinase on Ser30 and Ser85 by protein kinase A regulates phosphatidylcholine synthesis by the CDP-choline pathway

21 January 2018

1 reference

The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner

21 January 2018

1 reference

Preclinical pharmacokinetic/pharmacodynamic models to predict synergistic effects of co-administered anti-cancer agents

21 January 2018

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Metabolic signatures associated with a NAD synthesis inhibitor-induced tumor apoptosis identified by 1H-decoupled-31P magnetic resonance spectroscopy

21 January 2018

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Understanding the tumor metabolic phenotype in the genomic era.

21 January 2018

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Phase II study of flavopiridol in patients with advanced colorectal cancer

21 January 2018

1 reference

Flavopiridol down-regulates antiapoptotic proteins and sensitizes human breast cancer cells to epothilone B-induced apoptosis.

21 January 2018

1 reference

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Augmentation of apoptosis and tumor regression by flavopiridol in the presence of CPT-11 in Hct116 colon cancer monolayers and xenografts.

26 September 2018

1 reference

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In vivo antitumor activity of choline kinase inhibitors: a novel target for anticancer drug discovery.

26 September 2018

1 reference

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Choline deficiency-induced apoptosis in PC12 cells is associated with diminished membrane phosphatidylcholine and sphingomyelin, accumulation of ceramide and diacylglycerol, and activation of a caspase

26 September 2018

1 reference

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Removal of Dipolar Broadening of Nuclear Magnetic Resonance Spectra of Solids by Specimen Rotation

26 September 2018

1 reference

Quantitative analysis of apoptotic cell death using proton nuclear magnetic resonance spectroscopy

21 January 2018

1 reference

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Broadband proton decoupling in human 31P NMR spectroscopy

15 November 2018

1 reference

12 December 2020

Resolution enhanced NMR spectroscopy in biological systems via magnetic susceptibility matched sample immersion chambers

1 reference

12 December 2020

Phosphatidylcholine biosynthesis via the CDP-choline pathway in Saccharomyces cerevisiae. Multiple mechanisms of regulation

1 reference

12 December 2020

NMR lipid profiles of cells, tissues, and body fluids: proton NMR analysis of human erythrocyte lipids

1 reference

12 December 2020

Exercise-induced splitting of the inorganic phosphate peak: investigation by time-resolved 31P-nuclear magnetic resonance spectroscopy

1 reference

12 December 2020

A genetic defect in phosphatidylcholine biosynthesis triggers apoptosis in Chinese hamster ovary cells

1 reference

12 December 2020

31P-NMR investigation of solid tumours in the living rat

1 reference

12 December 2020

Identifiers

DOI

10.1002/NBM.1674

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21994185%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

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14 February 2020

PubMed publication ID

21994185

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