Therapeutic targets and biomarkers identified in cancer choline phospholipid metabolism (Q36630017)

15 August 2017

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title

Therapeutic targets and biomarkers identified in cancer choline phospholipid metabolism (English)

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15 August 2017

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Kristine Glunde

1

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PubMed ID

17054420

15 August 2017

Natalie J Serkova

series ordinal

2

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15 August 2017

1 October 2006

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15 August 2017

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15 August 2017

7

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15 August 2017

1109-1123

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15 August 2017

7

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Tumour phospholipid metabolism

15 August 2017

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1109

Choline phospholipid metabolism: a target in cancer cells?

21 January 2018

1 reference

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Applications of magnetic resonance in model systems: tumor biology and physiology

21 January 2018

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Applications of magnetic resonance in model systems: cancer therapeutics

21 January 2018

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Metabolic profiles of cancer cells

21 January 2018

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Studies of human tumors by MRS: a review

21 January 2018

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Imaging biochemistry: applications to breast cancer

21 January 2018

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Phosphomonoester concentrations differ between chronic lymphocytic leukemia cells and normal human lymphocytes

21 January 2018

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Alterations of choline phospholipid metabolism in ovarian tumor progression

21 January 2018

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Proton magnetic resonance spectroscopic imaging of human breast cancer: a preliminary study

21 January 2018

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In vivo 31P MR spectral patterns and reproducibility in cancer patients studied in a multi-institutional trial.

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.7.7.1109

Proton-decoupled 31P MRS in untreated pediatric brain tumors

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.7.7.1109

Regional metabolite concentrations in human brain as determined by quantitative localized proton MRS.

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.7.7.1109

Localized in vivo 1H magnetic resonance spectroscopy and in vitro analyses of heterogeneous brain tumors

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.7.7.1109

Biochemical characterization of pediatric brain tumors by using in vivo and ex vivo magnetic resonance spectroscopy

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.7.7.1109

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21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.7.7.1109

Metabolic profiles of human brain tumors using quantitative in vivo 1H magnetic resonance spectroscopy

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.7.7.1109

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21 January 2018

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Proton magnetic resonance spectroscopy in neuroblastoma: current status, prospects and limitations

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.7.7.1109

MRS of oligodendroglial tumors: correlation with histopathology and genetic subtypes

21 January 2018

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Assessment of malignancy in gliomas by 3T 1H MR spectroscopy .

21 January 2018

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Proton magnetic resonance spectroscopic evaluation of brain tumor metabolism

21 January 2018

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Three-dimensional H-1 MR spectroscopic imaging of the in situ human prostate with high (0.24-0.7-cm3) spatial resolution

21 January 2018

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Magnetic resonance spectroscopy of the malignant prostate gland after radiotherapy: a histopathologic study of diagnostic validity

21 January 2018

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Volume localized in vivo proton MR spectroscopy of breast carcinoma: variation of water-fat ratio in patients receiving chemotherapy

21 January 2018

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Human breast lesions: characterization with proton MR spectroscopy

21 January 2018

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Human breast lesions: characterization with contrast-enhanced in vivo proton MR spectroscopy--initial results

21 January 2018

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In vivo quantification of choline compounds in the breast with 1H MR spectroscopy.

21 January 2018

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Adding in vivo quantitative 1H MR spectroscopy to improve diagnostic accuracy of breast MR imaging: preliminary results of observer performance study at 4.0 T.

21 January 2018

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Specificity of choline metabolites for in vivo diagnosis of breast cancer using 1H MRS at 1.5 T.

21 January 2018

1 reference

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Quantification of choline-containing compounds in malignant breast tumors by 1H MR spectroscopy using water as an internal reference at 1.5 T.

21 January 2018

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Metabolic differences between primary and recurrent human brain tumors: a 1H NMR spectroscopic investigation

21 January 2018

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Proton HR‐MAS spectroscopy and quantitative pathologic analysis of MRI/3D‐MRSI‐targeted postsurgical prostate tissues

21 January 2018

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In vivo molecular imaging for planning radiation therapy of gliomas: an application of 1H MRSI.

21 January 2018

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Treatment planning for prostate implants using magnetic-resonance spectroscopy imaging.

21 January 2018

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High-grade gliomas and solitary metastases: differentiation by using perfusion and proton spectroscopic MR imaging

21 January 2018

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Neoadjuvant chemotherapy in breast cancer: early response prediction with quantitative MR imaging and spectroscopy

21 January 2018

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Three-dimensional magnetic resonance spectroscopic imaging of brain and prostate cancer

21 January 2018

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Time-dependent effects of hormone-deprivation therapy on prostate metabolism as detected by combined magnetic resonance imaging and 3D magnetic resonance spectroscopic imaging

21 January 2018

1 reference

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Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers

21 January 2018

1 reference

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Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy

21 January 2018

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Increased choline kinase activity in 1,2-dimethylhydrazine-induced rat colon cancer.

21 January 2018

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Increased choline kinase activity and elevated phosphocholine levels in human colon cancer

21 January 2018

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Molecular causes of the aberrant choline phospholipid metabolism in breast cancer

21 January 2018

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RNA interference-mediated choline kinase suppression in breast cancer cells induces differentiation and reduces proliferation

21 January 2018

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Inhibition of ChoK is an efficient antitumor strategy for Harvey-, Kirsten-, and N-ras-transformed cells.

21 January 2018

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Regulation of choline kinase activity by Ras proteins involves Ral-GDS and PI3K

21 January 2018

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Phosphatidylcholine-specific phospholipase C in mitogen-stimulated fibroblasts

21 January 2018

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Ha-ras-transformation alters the metabolism of phosphatidylethanolamine and phosphatidylcholine in NIH 3T3 fibroblasts

21 January 2018

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Expression of human choline kinase in NIH 3T3 fibroblasts increases the mitogenic potential of insulin and insulin-like growth factor I.

21 January 2018

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Phospholipase A(2) regulation of arachidonic acid mobilization

21 January 2018

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Phospholipase A2 expression in tumours: a target for therapeutic intervention?

21 January 2018

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Magnetic resonance detects changes in phosphocholine associated with Ras activation and inhibition in NIH 3T3 cells

21 January 2018

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Early increase in choline kinase activity upon induction of the H-ras oncogene in mouse fibroblast cell lines

21 January 2018

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Choline kinase inhibitors as a novel approach for antiproliferative drug design

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Inhibition of choline kinase as a specific cytotoxic strategy in oncogene-transformed cells.

21 January 2018

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Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models

21 January 2018

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Intracellular signaling by phospholipase D as a therapeutic target

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Minimally invasive pharmacokinetic and pharmacodynamic technologies in hypothesis-testing clinical trials of innovative therapies

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Differentiation between brain tumor recurrence and radiation injury using MR spectroscopy

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21 January 2018

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High-resolution magic-angle-spinning 1H NMR spectroscopy reveals different responses in choline-containing metabolites upon gene therapy-induced programmed cell death in rat brain glioma.

21 January 2018

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Tumor dose response to the vascular disrupting agent, 5,6-dimethylxanthenone-4-acetic acid, using in vivo magnetic resonance spectroscopy

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Exposure of human breast cancer cells to the anti-inflammatory agent indomethacin alters choline phospholipid metabolites and Nm23 expression

21 January 2018

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Increases in NMR-visible lipid and glycerophosphocholine during phenylbutyrate-induced apoptosis in human prostate cancer cells.

21 January 2018

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Identification of magnetic resonance detectable metabolic changes associated with inhibition of phosphoinositide 3-kinase signaling in human breast cancer cells

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Magnetic resonance spectroscopic pharmacodynamic markers of the heat shock protein 90 inhibitor 17-allylamino,17-demethoxygeldanamycin (17AAG) in human colon cancer models

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1H NMR visible lipids are induced by phosphonium salts and 5-fluorouracil in human breast cancer cells

21 January 2018

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Real-time changes in 1H and 31P NMR spectra of malignant human mammary epithelial cells during treatment with the anti-inflammatory agent indomethacin.

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Phospholipid metabolism and resistance to glucocorticoid-induced apoptosis in a human leukemic cell line: a 31P-NMR study using a phosphonium analog of choline

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Metabolic effects of photodynamically induced apoptosis in an erythroleukemic cell line. A (31)P NMR spectroscopic study of Victoria-Blue-BO-sensitized TF-1 cells

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Imatinib (STI571)-mediated changes in glucose metabolism in human leukemia BCR-ABL-positive cells

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Detection of resistance to imatinib by metabolic profiling: clinical and drug development implications

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Radiolabeled choline as a proliferation marker: comparison with radiolabeled acetate

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Choline kinase activation is a critical requirement for the proliferation of primary human mammary epithelial cells and breast tumor progression

21 January 2018

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Diagnosis and prognosis of breast cancer by magnetic resonance spectroscopy of fine-needle aspirates analysed using a statistical classification strategy

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10.2217/14622416.7.7.1109

21 January 2018

Identifiers

DOI

1 reference

15 August 2017

1 reference

PubMed ID

17054420