Human thrombomodulin knock-in mice reveal differential effects of human thrombomodulin on thrombosis and atherosclerosis (Q35457562)

8 August 2017

title

Human thrombomodulin knock-in mice reveal differential effects of human thrombomodulin on thrombosis and atherosclerosis (English)

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8 August 2017

Thomas J Raife

1

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8 August 2017

Denis M Dwyre

2

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8 August 2017

Jeff W Stevens

3

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8 August 2017

Rochelle A Erger

4

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8 August 2017

Lorie Leo

5

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8 August 2017

Katina M Wilson

6

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8 August 2017

Jose A Fernández

7

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8 August 2017

Jennifer Wilder

8

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8 August 2017

Hyung-Suk Kim

9

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8 August 2017

John H Griffin

10

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8 August 2017

Nobuyo Maeda

11

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8 August 2017

Steven R Lentz

12

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8 August 2017

language of work or name

English

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publication date

1 November 2011

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Arteriosclerosis, Thrombosis, and Vascular Biology

8 August 2017

published in

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8 August 2017

volume

31

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8 August 2017

issue

11

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8 August 2017

page(s)

2509-2517

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Hypercoagulability inhibits monocyte transendothelial migration through protease-activated receptor-1-, phospholipase-Cbeta-, phosphoinositide 3-kinase-, and nitric oxide-dependent signaling in monocytes and promotes plaque stability

8 August 2017

cites work

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Lectin-like domain of thrombomodulin binds to its specific ligand Lewis Y antigen and neutralizes lipopolysaccharide-induced inflammatory response

12 July 2018

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Enhanced susceptibility to arterial thrombosis in a murine model of hyperhomocysteinemia.

12 July 2018

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The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism

12 July 2018

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Interactions between the innate immune and blood coagulation systems

12 July 2018

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Thrombomodulin-protein C-EPCR system: integrated to regulate coagulation and inflammation

12 July 2018

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12 July 2018

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Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

12 July 2018

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The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor kappaB and mitogen-activated protein kinase pathways

12 July 2018

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Activation of endothelial cell protease activated receptor 1 by the protein C pathway

12 July 2018

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Naturally occurring mutations in the thrombomodulin gene leading to impaired expression and function

12 July 2018

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Molecular phenotyping for analyzing subtle genetic effects in mice: application to an angiotensinogen gene titration

12 July 2018

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

12 July 2018

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Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine beta-synthase-deficient mice.

12 July 2018

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Structure-function analyses of thrombomodulin by gene-targeting in mice: the cytoplasmic domain is not required for normal fetal development

12 July 2018

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Keratinocyte-specific expression of human thrombomodulin in transgenic mice: effects on epidermal differentiation and cutaneous wound healing

12 July 2018

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A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state

12 July 2018

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Influence of core protein sequence on glycosaminoglycan assembly

12 July 2018

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Efficient in vivo manipulation of mouse genomic sequences at the zygote stage

12 July 2018

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Structure-function relationships of the thrombin-thrombomodulin interaction

12 July 2018

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Identification of the predominant glycosaminoglycan-attachment site in soluble recombinant human thrombomodulin: potential regulation of functionality by glycosyltransferase competition for serine474

12 July 2018

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Modulation of glycosaminoglycan addition in naturally expressed and recombinant human thrombomodulin

12 July 2018

1 reference

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Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system

12 July 2018

1 reference

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Structure and function of thrombomodulin: a natural anticoagulant

12 July 2018

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Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E

12 July 2018

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Anti-inflammatory and anticoagulant effects of transgenic expression of human thrombomodulin in mice

12 July 2018

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Countervailing effects on atherogenesis and plaque stability: a paradoxical benefit of hypercoagulability?

26 September 2018

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The lectin-like domain of thrombomodulin interferes with complement activation and protects against arthritis.

26 September 2018

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A novel ELISA for mouse activated protein C in plasma.

26 September 2018

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Homozygosity for factor V Leiden leads to enhanced thrombosis and atherosclerosis in mice.

26 September 2018

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Effect of mechanical ventilation on carotid artery thrombosis induced by photochemical injury in mice.

26 September 2018

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Recombinant murine-activated protein C is neuroprotective in a murine ischemic stroke model

26 September 2018

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The thrombomodulin-protein C system is essential for the maintenance of pregnancy.

26 September 2018

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Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3202707

Tissue-restricted expression of thrombomodulin in the placenta rescues thrombomodulin-deficient mice from early lethality and reveals a secondary developmental block.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3202707

Characteristics of the core protein of the aggregating proteoglycan from the Swarm rat chondrosarcoma

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3202707

Thrombomodulin Gene Polymorphisms and Haplotypes and the Risk of Cardiovascular Events

15 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3202707

Dysfunction of Endothelial Protein C Activation in Severe Meningococcal Sepsis

15 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3202707

Thrombomodulin gene polymorphisms or haplotypes as potential risk factors for venous thromboembolism: a population-based case-control study

15 November 2018

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12 December 2020

Prothrombotic effects of hyperhomocysteinemia and hypercholesterolemia in ApoE-deficient mice

1 reference

12 December 2020

Expression of human tissue factor under the control of the mouse tissue factor promoter mediates normal hemostasis in knock-in mice

1 reference

12 December 2020

The chondroitin sulfate moiety of thrombomodulin binds a second molecule of thrombin

1 reference

12 December 2020

10.1161/ATVBAHA.111.236828

Identifiers

DOI

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8 August 2017

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8 August 2017

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