Kinase dynamics. Using ancient protein kinases to unravel a modern cancer drug's mechanism (Q35509663)

25700521

8 August 2017

title

Kinase dynamics. Using ancient protein kinases to unravel a modern cancer drug's mechanism (English)

1 reference

8 August 2017

1

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3 June 2020

Marc Hoemberger

3

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3 June 2020

Steffen Kutter

4

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3 June 2020

Adelajda Zorba

5

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3 June 2020

Renee Otten

8

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3 June 2020

author name string

R V Agafonov

2

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3 June 2020

J Halpin

6

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3 June 2020

V Buosi

7

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3 June 2020

D Waterman

9

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3 June 2020

D L Theobald

10

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D Kern

11

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3 June 2020

language of work or name

English

0 references

publication date

1 February 2015

1 reference

8 August 2017

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3 June 2020

volume

347

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3 June 2020

issue

6224

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3 June 2020

page(s)

882-886

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Energetic dissection of Gleevec's selectivity toward human tyrosine kinases.

3 June 2020

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Equally Potent Inhibition of c-Src and Abl by Compounds that Recognize Inactive Kinase Conformations

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A conserved protonation-dependent switch controls drug binding in the Abl kinase

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Crystal structure of the T315I Abl mutant in complex with the aurora kinases inhibitor PHA-739358

12 July 2018

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c-Src binds to the cancer drug imatinib with an inactive Abl/c-Kit conformation and a distributed thermodynamic penalty

12 July 2018

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Assessing the accuracy of ancestral protein reconstruction methods

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Missense meanderings in sequence space: a biophysical view of protein evolution

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Identifiers

DOI

10.1126/SCIENCE.AAA1823

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3 June 2020

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3 June 2020

25700521

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