Strategies to overcome resistance to targeted protein kinase inhibitors (Q35968384)

11 August 2017

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title

Strategies to overcome resistance to targeted protein kinase inhibitors (English)

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11 August 2017

Henrik Daub

1

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11 August 2017

Katja Specht

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2

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11 August 2017

Axel Ullrich

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3

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11 August 2017

1 December 2004

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Nature Reviews Drug Discovery

11 August 2017

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11 August 2017

3

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11 August 2017

12

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11 August 2017

1001-1010

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https://scigraph.springernature.com/pub.10.1038/nrd1579

11 August 2017

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Ph(+) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation

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Mutation of threonine 766 in the epidermal growth factor receptor reveals a hotspot for resistance formation against selective tyrosine kinase inhibitors

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Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo

31 March 2020

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31 March 2020

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An efficient proteomics method to identify the cellular targets of protein kinase inhibitors.

31 March 2020

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Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors

31 March 2020

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Evaluation of kinase inhibitor selectivity by chemical proteomics

31 March 2020

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Treatment-specific changes in gene expression discriminate in vivo drug response in human leukemia cells

31 March 2020

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Simultaneous suppression of epidermal growth factor receptor and c-erbB-2 reverses aneuploidy and malignant phenotype of a human ovarian carcinoma cell line.

31 March 2020

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HER-targeted tyrosine-kinase inhibitors

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD1579

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Dimensions Publication ID

11 August 2017

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