The c-MYC oncoprotein as a treatment target in cancer and other disorders of cell growth. (Q35537902)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14498825%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

review article

1 reference

title

The c-MYC oncoprotein as a treatment target in cancer and other disorders of cell growth (English)

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19 December 2019

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2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14498825%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

author name string

Stella Pelengaris

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14498825%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

language of work or name

English

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publication date

1 October 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14498825%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Therapeutic Targets

19 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14498825%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

volume

7

1 reference

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19 December 2019

issue

5

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19 December 2019

page(s)

623-642

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MYC oncogenes and human neoplastic disease

19 December 2019

cites work

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Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression.

21 January 2018

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Regulated subset of G1 growth-control genes in response to derepression by the Wnt pathway

21 January 2018

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Targeting c-Myb expression in human disease

21 January 2018

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Stable and unstable pools of Myc protein exist in human cells

21 January 2018

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Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc

21 January 2018

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Oncogenic activity of the c-Myc protein requires dimerization with Max.

21 January 2018

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New Myc-interacting proteins: a second Myc network emerges

21 January 2018

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Loss of protooncogene c-Myc function impedes G1 phase progression both before and after the restriction point

21 January 2018

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Increased expression of eukaryotic translation initiation factors eIF-4E and eIF-2 alpha in response to growth induction by c-myc

21 January 2018

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Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion

21 January 2018

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Drosophila myc regulates cellular growth during development.

21 January 2018

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Control of cell growth by c-Myc in the absence of cell division

21 January 2018

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Induction of cyclin E-cdk2 kinase activity, E2F-dependent transcription and cell growth by Myc are genetically separable events

21 January 2018

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Direct activation of RNA polymerase III transcription by c-Myc

21 January 2018

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Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27.

21 January 2018

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Identification of CDK4 as a target of c-MYC.

21 January 2018

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Cyclins D1 and D2 mediate myc-induced proliferation via sequestration of p27(Kip1) and p21(Cip1).

21 January 2018

1 reference

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Repression of p15INK4b expression by Myc through association with Miz-1

21 January 2018

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The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc

21 January 2018

1 reference

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Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter.

21 January 2018

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Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation.

21 January 2018

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Direct examination of histone acetylation on Myc target genes using chromatin immunoprecipitation

21 January 2018

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Cell-cycle progression is not essential for c-Myc to block differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.5.623

The Myc/Max/Mad network and the transcriptional control of cell behavior

21 January 2018

1 reference

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c-myc regulation during retinoic acid-induced differentiation of F9 cells is posttranscriptional and associated with growth arrest

21 January 2018

1 reference

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Contrasting roles for Myc and Mad proteins in cellular growth and differentiation

21 January 2018

1 reference

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c-Myc promotes differentiation of human epidermal stem cells

21 January 2018

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c-Myc enhances protein synthesis and cell size during B lymphocyte development

21 January 2018

1 reference

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Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3

21 January 2018

1 reference

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An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3

21 January 2018

1 reference

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Myc and Mad bHLHZ domains possess identical DNA-binding specificities but only partially overlapping functions in vivo

21 January 2018

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Induction of apoptosis in fibroblasts by c-myc protein

21 January 2018

1 reference

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Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

21 January 2018

1 reference

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Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis

21 January 2018

1 reference

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Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis

21 January 2018

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p53 and E2F-1 cooperate to mediate apoptosis

21 January 2018

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Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.

21 January 2018

1 reference

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Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

21 January 2018

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E2F1 and c-Myc potentiate apoptosis through inhibition of NF-kappaB activity that facilitates MnSOD-mediated ROS elimination

21 January 2018

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Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis

21 January 2018

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MycN and IFNgamma cooperate in apoptosis of human neuroblastoma cells.

21 January 2018

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c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release

21 January 2018

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Breaking the mitochondrial barrier

21 January 2018

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Myc potentiates apoptosis by stimulating Bax activity at the mitochondria

21 January 2018

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c-Myc functionally cooperates with Bax to induce apoptosis

21 January 2018

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c-MYC apoptotic function is mediated by NRF-1 target genes

21 January 2018

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Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

21 January 2018

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Withdrawal of IL-7 induces Bax translocation from cytosol to mitochondria through a rise in intracellular pH.

21 January 2018

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Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

21 January 2018

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Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator

21 January 2018

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Bax-induced cytochrome C release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions

21 January 2018

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c-Myc potentiates the mitochondrial pathway of apoptosis by acting upstream of apoptosis signal-regulating kinase 1 (Ask1) in the p38 signalling cascade

21 January 2018

1 reference

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Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution

21 January 2018

1 reference

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Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

21 January 2018

1 reference

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Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

21 January 2018

1 reference

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Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

21 January 2018

1 reference

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Guanine nucleotide exchange factor, Tiam1, directly binds to c-Myc and interferes with c-Myc-mediated apoptosis in rat-1 fibroblasts

21 January 2018

1 reference

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Biological activities of v-myc and rearranged c-myc oncogenes in rat fibroblast cells in culture

21 January 2018

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Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

21 January 2018

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Behavior of myc and ras oncogenes in transformation of rat embryo fibroblasts

21 January 2018

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Cooperative interaction between c-myc and bcl-2 proto-oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.5.623

BCL2-mediated tumorigenicity of a human T-lymphoid cell line: synergy with MYC and inhibition by BCL2 antisense

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.5.623

c-MYC: more than just a matter of life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.5.623

A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins

21 January 2018

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Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

21 January 2018

1 reference

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Activation of the myc oncoprotein leads to increased turnover of thrombospondin-1 mRNA

21 January 2018

1 reference

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Different regulation of vascular endothelial growth factor expression by the ERK and p38 kinase pathways in v-ras, v-raf, and v-myc transformed cells

21 January 2018

1 reference

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A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis

21 January 2018

1 reference

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Reversible tumorigenesis by MYC in hematopoietic lineages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.5.623

Recurrent allelic deletions at mouse chromosomes 4 and 14 in Myc-induced liver tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.5.623

Transient excess of MYC activity can elicit genomic instability and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.5.623

c-MYC overexpression in Ba/F3 cells simultaneously elicits genomic instability and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.5.623

The myc oncogene: MarvelouslY Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.5.623

A mutation in the c-myc-IRES leads to enhanced internal ribosome entry in multiple myeloma: a novel mechanism of oncogene de-regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.5.623

Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.5.623

Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.5.623

Regulation of c-myc expression by PDGF through Rho GTPases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.5.623

Identification of high-risk breast cancer patients from genetic changes of their tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.5.623

c-Myc proteolysis by the ubiquitin-proteasome pathway: stabilization of c-Myc in Burkitt's lymphoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.5.623

Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.5.623

Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.5.623

Modelling the molecular circuitry of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.5.623

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.5.623

Islet growth and development in the adult

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.5.623

Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes

21 January 2018

1 reference

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Identifying genes regulated in a Myc-dependent manner

21 January 2018

1 reference

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The transcriptional program of a human B cell line in response to Myc

21 January 2018

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Analysis of gene expression during myc oncogene-induced lymphomagenesis in the bursa of Fabricius

21 January 2018

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Antisense anticancer oligonucleotide therapeutics

21 January 2018

1 reference

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Resistance to chemotherapeutic drugs overcome by c-Myc inhibition in a Lewis lung carcinoma murine model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.5.623

Drug-eluting stents in vascular intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.5.623

Intramural coronary delivery of advanced antisense oligonucleotides reduces neointimal formation in the porcine stent restenosis model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.5.623

A novel myc target gene, mina53, that is involved in cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.5.623

c-Myc is required for the glucose-mediated induction of metabolic enzyme genes

21 January 2018

1 reference

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Essential role for oncogenic Ras in tumour maintenance

21 January 2018

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Reversibility of acute B-cell leukaemia induced by BCR-ABL1.

21 January 2018

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Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.5.623

Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.5.623

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.5.623

21 January 2018

Identifiers

DOI

10.1517/14728222.7.5.623

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14498825%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

1 reference