Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration (Q35546888)

8 August 2017

title

Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration (English)

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8 August 2017

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Lincoln V Johnson

1

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8 August 2017

David L Forest

2

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8 August 2017

Christopher D Banna

3

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8 August 2017

Carolyn M Radeke

4

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8 August 2017

Michelle A Maloney

5

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8 August 2017

Jane Hu

6

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8 August 2017

Christine N Spencer

7

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8 August 2017

Aimee M Walker

8

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8 August 2017

Marlene S Tsie

9

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8 August 2017

Dean Bok

10

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8 August 2017

Monte J Radeke

11

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8 August 2017

Don H Anderson

12

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8 August 2017

language of work or name

English

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publication date

3 October 2011

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Proceedings of the National Academy of Sciences of the United States of America

8 August 2017

published in

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8 August 2017

volume

108

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8 August 2017

issue

45

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8 August 2017

page(s)

18277-18282

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Bisretinoids of RPE lipofuscin: trigger for complement activation in age-related macular degeneration

8 August 2017

cites work

1 reference

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Genetic control of complement activation in humans and age related macular degeneration

12 July 2018

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Abundant lipid and protein components of drusen

12 July 2018

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A hapten generated from an oxidation fragment of docosahexaenoic acid is sufficient to initiate age-related macular degeneration

12 July 2018

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Complement, age-related macular degeneration and a vision of the future

12 July 2018

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The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited

12 July 2018

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12 July 2018

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Proteomics characterization of cell membrane blebs in human retinal pigment epithelium cells

12 July 2018

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Increased vitronectin production by complement-stimulated human retinal pigment epithelial cells

12 July 2018

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Regulated secretion of complement factor H by RPE and its role in RPE migration

12 July 2018

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12 July 2018

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C1q binds phosphatidylserine and likely acts as a multiligand-bridging molecule in apoptotic cell recognition

12 July 2018

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Repetitive nonlethal oxidant injury to retinal pigment epithelium decreased extracellular matrix turnover in vitro and induced sub-RPE deposits in vivo

12 July 2018

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Complement proteins C1q and MBL are pattern recognition molecules that signal immediate and long-term protective immune functions

12 July 2018

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Confluent monolayers of cultured human fetal retinal pigment epithelium exhibit morphology and physiology of native tissue.

12 July 2018

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Structure and activation of the C1 complex of complement: unraveling the puzzle.

12 July 2018

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Characterization of beta amyloid assemblies in drusen: the deposits associated with aging and age-related macular degeneration

12 July 2018

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Regulated expression of apolipoprotein E by human retinal pigment epithelial cells

12 July 2018

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Apolipoprotein B in cholesterol-containing drusen and basal deposits of human eyes with age-related maculopathy

12 July 2018

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Drusen proteome analysis: an approach to the etiology of age-related macular degeneration.

12 July 2018

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A role for local inflammation in the formation of drusen in the aging eye.

12 July 2018

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Complement activation and inflammatory processes in Drusen formation and age related macular degeneration

12 July 2018

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An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration

12 July 2018

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Local cellular sources of apolipoprotein E in the human retina and retinal pigmented epithelium: implications for the process of drusen formation

12 July 2018

1 reference

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A cell culture medium that supports the differentiation of human retinal pigment epithelium into functionally polarized monolayers

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3215058

Accumulation of cholesterol with age in human Bruch's membrane.

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3215058

Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3215058

Vitronectin gene expression in the adult human retina

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3215058

Molecular composition of drusen as related to substructural phenotype

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3215058

Early drusen formation in the normal and aging eye and their relation to age related maculopathy: a clinicopathological study

12 July 2018

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Clinico-morphologic correlations of drusen of Bruch's membrane

12 July 2018

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12 July 2018

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Scanning electron microscopy of human drusen

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3215058

A mechanism of activation of the alternative complement pathway by the classical pathway: protection of C3b from inactivation by covalent attachment to C4b.

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3215058

Ageing and degeneration in the macular region: a clinico-pathological study

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3215058

Expression and modulation of RPE cell membrane complement regulatory proteins.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3215058

Relationship of Basal laminar deposit and membranous debris to the clinical presentation of early age-related macular degeneration

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3215058

Secreted proteome profiling in human RPE cell cultures derived from donors with age related macular degeneration and age matched healthy donors.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3215058

Senile macular degeneration: a histopathologic study. 1977.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3215058

Lipoprotein-like particles and cholesteryl esters in human Bruch's membrane: initial characterization

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3215058

Modulation of Sub-RPE deposits in vitro: a potential model for age-related macular degeneration

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3215058

Structure and composition of drusen associated with glomerulonephritis: implications for the role of complement activation in drusen biogenesis.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3215058

A potential role for immune complex pathogenesis in drusen formation

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3215058

The Ultrastructure of Drusen

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3215058

Epigenetic regulation of clusterin/apolipoprotein J expression in retinal pigment epithelial cells

26 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1109703108

Distribution of complement anaphylatoxin receptors and membrane-bound regulators in normal human retina

21 January 2018

1 reference

12 December 2020

Formation of drusen in the human eye

1 reference

12 December 2020

Morphologic changes in age-related maculopathy

1 reference

12 December 2020

Location, substructure, and composition of basal laminar drusen compared with drusen associated with aging and age-related macular degeneration

1 reference

12 December 2020

The globular heads of C1q specifically recognize surface blebs of apoptotic vascular endothelial cells

1 reference

12 December 2020

Direct binding of C1q to apoptotic cells and cell blebs induces complement activation

1 reference

12 December 2020

Activation of the complement system by different autologous transfusion devices: an in vitro study

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1109703108

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8 August 2017

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8 August 2017

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