Efficacy and pharmacokinetic/pharmacodynamic evaluation of the Aurora kinase A inhibitor MLN8237 against preclinical models of pediatric cancer. (Q35549470)

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scientific article published on 30 March 2011

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English	Efficacy and pharmacokinetic/pharmacodynamic evaluation of the Aurora kinase A inhibitor MLN8237 against preclinical models of pediatric cancer.	scientific article published on 30 March 2011

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scholarly article

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Efficacy and pharmacokinetic/pharmacodynamic evaluation of the Aurora kinase A inhibitor MLN8237 against preclinical models of pediatric cancer (English)

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pharmacokinetics

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pharmacodynamics

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Richard G Gorlick

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Malcolm A Smith

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Peter J. Houghton

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Peter J Houghton

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John M Maris

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E Anders Kolb

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Stephen T Keir

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Hernan Carol

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Amy E Wozniak

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Geoffrey Neale

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Ingrid Boehm

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author name string

Christopher L Morton

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Jianrong Wu

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Yu Yang

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Mark Manfredi

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Jeffrey Ecsedy

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Jianmin Wang

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publication date

30 March 2011

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Cancer Chemotherapy and Pharmacology

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5

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1291-1304

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27 January 2020

https://scigraph.springernature.com/pub.10.1007/s00280-011-1618-8

0 references

National Cancer Institute pediatric preclinical testing program: model description for in vitro cytotoxicity testing

1 reference

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12 July 2018

Drug-resistant aurora A mutants for cellular target validation of the small molecule kinase inhibitors MLN8054 and MLN8237

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12 July 2018

Initial testing of the aurora kinase A inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3215888

12 July 2018

Aurora-A down-regulates IkappaBalpha via Akt activation and interacts with insulin-like growth factor-1 induced phosphatidylinositol 3-kinase pathway for cancer cell survival

1 reference

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12 July 2018

Aurora A is a negative prognostic factor and a new therapeutic target in human neuroblastoma

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12 July 2018

Small molecule aurora kinases inhibitors.

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12 July 2018

The inhibition of Aurora A abrogates the mitotic delay induced by microtubule perturbing agents

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12 July 2018

UA62784, a novel inhibitor of centromere protein E kinesin-like protein

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12 July 2018

Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma

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12 July 2018

Aurora-A kinase is essential for bipolar spindle formation and early development

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12 July 2018

EWS-Fli1 up-regulates expression of the Aurora A and Aurora B kinases.

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12 July 2018

Reference alignment of SNP microarray signals for copy number analysis of tumors

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12 July 2018

Aurora kinase A inhibition leads to p73-dependent apoptosis in p53-deficient cancer cells

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12 July 2018

The Aurora kinase family in cell division and cancer.

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12 July 2018

Molecular characterization of the pediatric preclinical testing panel

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12 July 2018

Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

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12 July 2018

Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry

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12 July 2018

Aurora kinases as anticancer drug targets

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12 July 2018

Aurora kinase inhibitors: identification and preclinical validation of their biomarkers

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12 July 2018

Initial testing (stage 1) of the proteasome inhibitor bortezomib by the pediatric preclinical testing program.

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A fluorescence microplate cytotoxicity assay with a 4-log dynamic range that identifies synergistic drug combinations

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12 July 2018

Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase

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12 July 2018

Targeted anti-mitotic therapies: can we improve on tubulin agents?

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Tubulin-associated drug targets: Aurora kinases, Polo-like kinases, and others

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12 July 2018

Evaluation of the antitumor efficacy, pharmacokinetics, and pharmacodynamics of the histone deacetylase inhibitor depsipeptide in childhood cancer models in vivo

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12 July 2018

In vivo evaluation of ixabepilone (BMS247550), a novel epothilone B derivative, against pediatric cancer models

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12 July 2018

Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death.

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12 July 2018

Circular binary segmentation for the analysis of array-based DNA copy number data

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12 July 2018

Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215.

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12 July 2018

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12 July 2018

An integrated view of copy number and allelic alterations in the cancer genome using single nucleotide polymorphism arrays

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12 July 2018

Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies

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12 July 2018

Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells

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12 July 2018

The Aurora kinases: role in cell transformation and tumorigenesis

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12 July 2018

AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol

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12 July 2018

Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases

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12 July 2018

Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis

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Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

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12 July 2018

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

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12 July 2018

Experimental chemotherapy of human medulloblastoma cell lines and transplantable xenografts with bifunctional alkylating agents

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27 July 2018

Unholy matrimony: Aurora A and N-Myc as malignant partners in neuroblastoma.

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26 September 2018

Potentiation of kinesin spindle protein inhibitor-induced cell death by modulation of mitochondrial and death receptor apoptotic pathways.

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26 September 2018

The pediatric preclinical testing program: description of models and early testing results.

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26 September 2018

Amplification/overexpression of a mitotic kinase gene in human bladder cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/21448591

12 December 2020

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10.1007/S00280-011-1618-8

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27 January 2020

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