Insulin-degrading enzyme sorting in exosomes: a secretory pathway for a key brain amyloid-beta degrading protease (Q35552504)

8 August 2017

Insulin-degrading enzyme sorting in exosomes: a secretory pathway for a key brain amyloid-beta degrading protease (English)

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8 August 2017

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Ayelén Bulloj

1

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8 August 2017

María C Leal

2

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8 August 2017

Huaxi Xu

3

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8 August 2017

Eduardo M Castaño

4

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8 August 2017

Laura Morelli

5

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8 August 2017

1 January 2010

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Journal of Alzheimer's Disease

8 August 2017

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8 August 2017

19

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8 August 2017

1

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8 August 2017

79-95

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describes a project that uses

8 August 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4414343/fullTextXML

inferred from PubMed Central ID database lookup

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The catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid beta peptide: implications for Alzheimer disease pathogenesis

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

27 July 2018

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Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme

27 July 2018

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Receptor downregulation and multivesicular-body sorting

27 July 2018

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Exosomes: composition, biogenesis and function

27 July 2018

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Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

27 July 2018

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Sorting of proteins into multivesicular bodies: ubiquitin-dependent and -independent targeting

27 July 2018

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Localization of lysobisphosphatidic acid-rich membrane domains in late endosomes

27 July 2018

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Overexpression of Rab11 or constitutively active Rab11 does not affect sAPPalpha and Abeta secretions by wild-type and Swedish mutated betaAPP-expressing HEK293 cells.

27 July 2018

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Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme

27 July 2018

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Secretion of the galectin family of mammalian carbohydrate-binding proteins

27 July 2018

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Plasma membrane targetting, vesicular budding and release of galectin 3 from the cytoplasm of mammalian cells during secretion.

27 July 2018

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Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation

27 July 2018

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Association of insulin-degrading enzyme with a 70 kDa cytosolic protein in hepatoma cells

27 July 2018

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B lymphocytes secrete antigen-presenting vesicles

27 July 2018

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Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus

27 July 2018

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Differential effects of a Rab6 mutant on secretory versus amyloidogenic processing of Alzheimer's beta-amyloid precursor protein

27 July 2018

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Diversity of group types, regulation, and function of phospholipase A2

27 July 2018

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Evidence that production and release of amyloid beta-protein involves the endocytic pathway

27 July 2018

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27 July 2018

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Complete inhibition of transferrin recycling by monensin in K562 cells.

27 July 2018

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Speculations on the functions of the major heat shock and glucose-regulated proteins

27 July 2018

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Amino acid sequence of rabbit kidney neutral endopeptidase 24.11 (enkephalinase) deduced from a complementary DNA.

27 July 2018

1 reference

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A non-exchangeable fluorescent phospholipid analog as a membrane traffic marker of the endocytic pathway

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4414343

Insulin-degrading enzyme is exported via an unconventional protein secretion pathway

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4414343

Detergent resistant membrane-associated IDE in brain tissue and cultured cells: Relevance to Abeta and insulin degradation

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4414343

ApoE promotes the proteolytic degradation of Abeta

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4414343

Insulin degrading enzyme is a cellular receptor mediating varicella-zoster virus infection and cell-to-cell spread

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4414343

Plaque-associated overexpression of insulin-degrading enzyme in the cerebral cortex of aged transgenic tg2576 mice with Alzheimer pathology.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4414343

Alzheimer's disease beta-amyloid peptides are released in association with exosomes

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4414343

The regulation of exosome secretion: a novel function of the p53 protein

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4414343

Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4414343

Rab11 promotes docking and fusion of multivesicular bodies in a calcium-dependent manner

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4414343

Exosomes: endosomal-derived vesicles shipping extracellular messages

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4414343

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4414343

Prospects for prevention and treatment of vascular cognitive impairment

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4414343

Metabolic regulation of brain Abeta by neprilysin.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4414343

Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of beta-amyloid peptide.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4414343

Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4414343

Expression of amyloid precursor protein (beta-APP) in the neonatal brain following hypoxic ischaemic injury.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4414343

Rise in cytoplasmic Ca2+ induced by monensin in bovine medullary chromaffin cells.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4414343

Insulin-degrading enzyme in brain microvessels: proteolysis of amyloid {beta} vasculotropic variants and reduced activity in cerebral amyloid angiopathy

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20061628

12 December 2020

inferred from PubMed ID database lookup

Exosome formation during maturation of mammalian and avian reticulocytes: evidence that exosome release is a major route for externalization of obsolete membrane proteins

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20061628

12 December 2020

inferred from PubMed ID database lookup

Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20061628

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.3233/JAD-2010-1206

1 reference

8 August 2017

1 reference

8 August 2017

1 reference