Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans (Q35554316)

8 August 2017

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title

Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans (English)

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8 August 2017

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3

Claudio Franceschi

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8 August 2017

Michelangela Barbieri

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1

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PubMed ID

14534077

8 August 2017

Massimiliano Bonafè

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2

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PubMed ID

14534077

8 August 2017

Giuseppe Paolisso

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4

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8 August 2017

1 November 2003

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American Journal of Physiology - Endocrinology and Metabolism

8 August 2017

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8 August 2017

285

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8 August 2017

E1064-71

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8 August 2017

5

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Insulin-Like growth factor I: implications in aging

8 August 2017

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https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

Insulin-like growth factor 1 (IGF-1) and aging: controversies and new insights

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

Extended longevity in mice lacking the insulin receptor in adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

Dwarf mice and the ageing process.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

Models of growth hormone and IGF-1 deficiency: applications to studies of aging processes and life-span determination

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

Mouse mutants as models in endocrine research

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

A heady message for lifespan regulation.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

Regulation of longevity and stress resistance by Sch9 in yeast

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

Insulin resistance as a predictor of age-related diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

Insulin/IGF signalling and ageing: seeing the bigger picture

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

Oxidative stress and life span determination in the nematode Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

Effect of diet restriction on glucose metabolism and insulin responsiveness in aging rats

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

A conserved regulatory system for aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

Evolutionary medicine: from dwarf model systems to healthy centenarians?

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

Plasma antioxidants and longevity: a study on healthy centenarians.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

The p66shc adaptor protein controls oxidative stress response and life span in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

Metabolic age modelling: the lesson from centenarians

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

Low insulin resistance and preserved beta-cell function contribute to human longevity but are not associated with TH-INS genes.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

Oxidative stress and advancing age: results in healthy centenarians.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

Evolution of germ-line signals that regulate growth and aging in nematodes

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

The Drosophila insulin receptor contains a novel carboxyl-terminal extension likely to play an important role in signal transduction

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

Lipid peroxidation in aging and age-dependent diseases

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

The endocrine regulation of aging by insulin-like signals

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

Novel sensing mechanisms and targets for the cAMP-protein kinase A pathway in the yeast Saccharomyces cerevisiae

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

Mechanisms of life span determination in Caenorhabditis elegans

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

Sex hormone-induced prostatic carcinogenesis in the noble rat: the role of insulin-like growth factor-I (IGF-I) and vascular endothelial growth factor (VEGF) in the development of prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

Seminars in medicine of the Beth Israel Deaconess Medical Center. Caloric intake and aging

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

The genetic control of organ growth: insights from Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

Regulation of C. elegans life-span by insulinlike signaling in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

Genes, demography, and life span: the contribution of demographic data in genetic studies on aging and longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00296.2003

10.1152/AJPENDO.00296.2003

21 January 2018

Identifiers

DOI

1 reference

8 August 2017

1 reference

PubMed ID

14534077