Deficiency for costimulatory receptor 4-1BB protects against obesity-induced inflammation and metabolic disorders (Q35561102)

8 August 2017

Deficiency for costimulatory receptor 4-1BB protects against obesity-induced inflammation and metabolic disorders (English)

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8 August 2017

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6

Teruo Kawada

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8 August 2017

Chu-Sook Kim

1

1 reference

8 August 2017

Jae Geun Kim

2

1 reference

8 August 2017

Byung-Ju Lee

3

1 reference

8 August 2017

Myung-Sook Choi

4

1 reference

8 August 2017

Hye-Sun Choi

5

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8 August 2017

Ki-Up Lee

7

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8 August 2017

Rina Yu

8

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8 August 2017

language of work or name

English

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publication date

13 October 2011

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8 August 2017

10

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inferred from page(s)

published in

Diabetes

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8 August 2017

60

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8 August 2017

3159-3168

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8 August 2017

12

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

8 August 2017

start time

27 August 2021

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Palmitate induced IL-6 and MCP-1 expression in human bladder smooth muscle cells provides a link between diabetes and urinary tract infections

12 July 2018

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12 July 2018

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Uncoupling of inflammation and insulin resistance by NF-kappaB in transgenic mice through elevated energy expenditure

12 July 2018

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Deletion of tumor necrosis factor-alpha receptor 1 (TNFR1) protects against diet-induced obesity by means of increased thermogenesis

12 July 2018

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The protein kinase IKKepsilon regulates energy balance in obese mice

12 July 2018

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CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Neutralizing anti-4-1BBL treatment improves cardiac function in viral myocarditis

12 July 2018

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Improved insulin sensitivity by anti-TNFalpha antibody treatment in patients with rheumatic diseases

12 July 2018

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Inflammation and metabolic disorders

12 July 2018

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Inflammation and insulin resistance

12 July 2018

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AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARalpha and PGC-1.

12 July 2018

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Biological activities of reverse signal transduction through CD137 ligand

12 July 2018

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Obesity is associated with macrophage accumulation in adipose tissue

12 July 2018

1 reference

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Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?

12 July 2018

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Mitochondrial dysfunction in the elderly: possible role in insulin resistance

12 July 2018

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A central role for JNK in obesity and insulin resistance

12 July 2018

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Diet-induced insulin resistance in mice lacking adiponectin/ACRP30

12 July 2018

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Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice

12 July 2018

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Cellular mechanisms of insulin resistance

12 July 2018

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Intestinal inflammation: a complex interplay of immune and nonimmune cell interactions

12 July 2018

1 reference

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4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses

12 July 2018

1 reference

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NF-kappa B: ten years after

12 July 2018

1 reference

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Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

12 July 2018

1 reference

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Dechlorination of halocarbons by microsomes and vesicular reconstituted cytochrome P-450 systems under reductive conditions

12 July 2018

1 reference

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Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219944

CD137 (4-1BB) deficiency reduces atherosclerosis in hyperlipidemic mice.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219944

Attenuation of experimental autoimmune myocarditis by blocking T cell activation through 4-1BB pathway.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219944

Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219944

CD137 is expressed on blood vessel walls at sites of inflammation and enhances monocyte migratory activity.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219944

4-1BB-mediated immunotherapy of rheumatoid arthritis.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219944

Expression of CD137 and its ligand in human neurons, astrocytes, and microglia: modulation by FGF-2.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219944

Blocking 4-1BB/4-1BB ligand interactions prevents herpetic stromal keratitis.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219944

Immune responses in 4-1BB (CD137)-deficient mice

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219944

4-1BB-like molecule is expressed in islet-infiltrating mononuclear cells and in the gray matter of the brain.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219944

Reduced hepatic fatty acid oxidation in fasting PPARalpha null mice is due to impaired mitochondrial hydroxymethylglutaryl-CoA synthase gene expression.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219944

Role of 4-1BB in immune responses.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219944

Effects of an engineered human anti-TNF-alpha antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219944

Potential role of 4-1BB in T cell activation. Comparison with the costimulatory molecule CD28

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219944

Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal

24 October 2018

1 reference

12 December 2020

Signal transduction mechanisms of CD137 ligand in human monocytes

1 reference

12 December 2020

CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic mice

1 reference

12 December 2020

T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance

1 reference

12 December 2020

No increased insulin sensitivity after a single intravenous administration of a recombinant human tumor necrosis factor receptor: Fc fusion protein in obese insulin-resistant patients

1 reference

12 December 2020

TNF-alpha inhibits UCP-1 expression in brown adipocytes via ERKs. Opposite effect of p38MAPK

1 reference

12 December 2020

The two faces of IKK and NF-κB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion

1 reference

12 December 2020

Identifiers

DOI

10.2337/DB10-1805

1 reference

8 August 2017

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8 August 2017

1 reference