Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and Xenopus oocytes (Q35562454)

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scientific article published on September 2002

Language	Label	Description	Also known as
English	Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and Xenopus oocytes	scientific article published on September 2002

Statements

scholarly article

1 reference

Europe PubMed Central

8 August 2017

1 reference

Europe PubMed Central

Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and Xenopus oocytes (English)

1 reference

Europe PubMed Central

8 August 2017

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John S Mitcheson

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author name string

Harry J Witchel

1

1 reference

Europe PubMed Central

8 August 2017

James T Milnes

2

1 reference

Europe PubMed Central

8 August 2017

John S Mitcheson

3

1 reference

Europe PubMed Central

8 August 2017

Jules C Hancox

4

1 reference

Europe PubMed Central

8 August 2017

publication date

1 September 2002

1 reference

Europe PubMed Central

8 August 2017

Journal of Pharmacological and Toxicological Methods

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Europe PubMed Central

8 August 2017

48

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Europe PubMed Central

8 August 2017

2

1 reference

Europe PubMed Central

8 August 2017

65-80

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Europe PubMed Central

8 August 2017

Disease-associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Long-term exposure to retinoic acid induces the expression of IRK1 channels in HERG channel-endowed neuroblastoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

HERG- and IRK-like inward rectifier currents are sequentially expressed during neuronal development of neural crest cells and their derivatives.

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

The minK potassium channel exists in functional and nonfunctional forms when expressed in the plasma membrane of Xenopus oocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Blockade of HERG channels by the class III antiarrhythmic azimilide: mode of action

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Patch clamp techniques: an overview

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

QT interval prolongation by non-cardiovascular drugs: issues and solutions for novel drug development

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Cyclic AMP regulates the HERG K(+) channel by dual pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Erythromycin blocks the rapid component of the delayed rectifier potassium current and lengthens repolarization of guinea pig ventricular myocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

A HERG-like K+ channel in rat F-11 DRG cell line: pharmacological identification and biophysical characterization

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

[3H]dofetilide binding to HERG transfected membranes: a potential high throughput preclinical screen.

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Time course and voltage dependence of expressed HERG current compared with native "rapid" delayed rectifier K current during the cardiac ventricular action potential

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Functional characterization of a minimal K+ channel expressed from a synthetic gene

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

The potential for QT prolongation and pro-arrhythmia by non-anti-arrhythmic drugs: clinical and regulatory implications. Report on a Policy Conference of the European Society of Cardiology.

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

X-ray structure of a voltage-dependent K+ channel

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Rate-dependent prolongation of cardiac action potentials by a methanesulfonanilide class III antiarrhythmic agent. Specific block of rapidly activating delayed rectifier K+ current by dofetilide

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Open channel block of HERG K(+) channels by vesnarinone.

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

A method for making rapid changes of superfusate whilst maintaining temperature at 37 degrees C

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

The role of the cap structure in RNA processing and nuclear export

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular interactions between two long-QT syndrome gene products, HERG and KCNE2, rationalized by in vitro and in silico analysis

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

A minK-HERG complex regulates the cardiac potassium current I(Kr)

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Blocking effects of the antiarrhythmic drug propafenone on the HERG potassium channel

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

A structural basis for drug-induced long QT syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate.

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Screening lead compounds for QT interval prolongation

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Probing the interaction between inactivation gating and Dd-sotalol block of HERG.

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of HERG potassium channel current by the class 1a antiarrhythmic agent disopyramide

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

N-linked glycosylation sites determine HERG channel surface membrane expression

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Modulation of HERG potassium channels by extracellular magnesium and quinidine

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

LQT2 : amplitude reduction and loss of selectivity in the tail that wags the HERG channel.

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel.

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

A common polymorphism associated with antibiotic-induced cardiac arrhythmia

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Conductance and kinetics of delayed rectifier potassium channels in nodal cells of the rabbit heart.

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of an inwardly rectifying potassium current in rabbit ventricular action potential

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

The inward rectification mechanism of the HERG cardiac potassium channel

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of the current of heterologously expressed HERG potassium channels by imipramine and amitriptyline

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

HERG, a human inward rectifier in the voltage-gated potassium channel family

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

I(Kr): the hERG channel

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

The use of Xenopus laevis oocytes for the functional characterization of heterologously expressed membrane proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

A comparison of currents carried by HERG, with and without coexpression of MiRP1, and the native rapid delayed rectifier current. Is MiRP1 the missing link?

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Familial and acquired long qt syndrome and the cardiac rapid delayed rectifier potassium current

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Rapid inactivation determines the rectification and [K+]o dependence of the rapid component of the delayed rectifier K+ current in cardiac cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

MinK-related peptide 1: A beta subunit for the HCN ion channel subunit family enhances expression and speeds activation

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

minK-related peptide 1 associates with Kv4.2 and modulates its gating function: potential role as beta subunit of cardiac transient outward channel?

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

A mutation in the pore region of HERG K+ channels expressed in Xenopus oocytes reduces rectification by shifting the voltage dependence of inactivation.

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2803%2900041-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S1056-8719(03)00041-8

1 reference

Europe PubMed Central

8 August 2017

1 reference

Europe PubMed Central

8 August 2017

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