Pharmacokinetics of orally administered uracil in healthy volunteers and in DPD-deficient patients, a possible tool for screening of DPD deficiency. (Q35563540)

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scientific article published on 18 May 2011

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English	Pharmacokinetics of orally administered uracil in healthy volunteers and in DPD-deficient patients, a possible tool for screening of DPD deficiency.	scientific article published on 18 May 2011

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scholarly article

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1 February 2020

Pharmacokinetics of orally administered uracil in healthy volunteers and in DPD-deficient patients, a possible tool for screening of DPD deficiency (English)

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Europe PubMed Central

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1 February 2020

pharmacokinetics

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based on heuristic

inferred from title

Henk-Jan Guchelaar

3

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1 February 2020

author name string

Maurice C van Staveren

1

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1 February 2020

Barbara Theeuwes-Oonk

2

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1 February 2020

André B P van Kuilenburg

4

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1 February 2020

Jan Gerard Maring

5

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1 February 2020

publication date

18 May 2011

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1 February 2020

Cancer Chemotherapy and Pharmacology

1 reference

Europe PubMed Central

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1 February 2020

68

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1 February 2020

6

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1 February 2020

1611-1617

1 reference

Europe PubMed Central

PMC publication ID

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1 February 2020

Effects of systemic chemotherapy on the liver

1 reference

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1 reference

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1 reference

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1 reference

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27 July 2018

The uracil breath test in the assessment of dihydropyrimidine dehydrogenase activity: pharmacokinetic relationship between expired 13CO2 and plasma [2-13C]dihydrouracil

1 reference

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27 July 2018

Physiologically based pharmacokinetic modelling of the three-step metabolism of pyrimidine using C-uracil as an in vivo probe

1 reference

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27 July 2018

Toxic death-case after capecitabine + oxaliplatin (XELOX) administration: probable implication of dihydropyrimidine deshydrogenase deficiency

1 reference

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1 reference

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Fluorouracil: biochemistry and pharmacology

1 reference

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A phase III trial of 5-fluorouracil and leucovorin in the treatment of advanced colorectal cancer. A Mayo Clinic/North Central Cancer Treatment Group study

1 reference

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27 July 2018

Reduced 5-FU clearance in a patient with low DPD activity due to heterozygosity for a mutant allele of the DPYD gene.

1 reference

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21 January 2018

Pharmacokinetics of 5-fluorouracil in patients heterozygous for the IVS14+1G > A mutation in the dihydropyrimidine dehydrogenase gene

1 reference

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21 January 2018

Increased risk of grade IV neutropenia after administration of 5-fluorouracil due to a dihydropyrimidine dehydrogenase deficiency: high prevalence of the IVS14+1g>a mutation

1 reference

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21 January 2018

5-Fluorouracil-related severe toxicity: a comparison of different methods for the pretherapeutic detection of dihydropyrimidine dehydrogenase deficiency

1 reference

https://api.crossref.org/works/10.1007%2FS00280-011-1661-5

21 January 2018

High prevalence of the IVS14 + 1G>A mutation in the dihydropyrimidine dehydrogenase gene of patients with severe 5-fluorouracil-associated toxicity

1 reference

https://api.crossref.org/works/10.1007%2FS00280-011-1661-5

21 January 2018

Rapid identification of dihydropyrimidine dehydrogenase deficiency by using a novel 2-13C-uracil breath test

1 reference

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21 January 2018

The value of dihydrouracil/uracil plasma ratios in predicting 5-fluorouracil-related toxicity in colorectal cancer patients

1 reference

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21 January 2018

Pharmacokinetics, a main actor in a many-sided approach to severe 5-FU toxicity prediction

1 reference

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21 January 2018

The dihydrouracil/uracil ratio in plasma, clinical and genetic analysis for screening of dihydropyrimidine dehydrogenase deficiency in colorectal cancer patients treated with 5-fluorouracil

1 reference

https://api.crossref.org/works/10.1007%2FS00280-011-1661-5

21 January 2018

A simple and rapid high-performance liquid chromatographic (HPLC) method for 5-fluorouracil (5-FU) assay in plasma and possible detection of patients with impaired dihydropyrimidine dehydrogenase (DPD) activity

1 reference

https://api.crossref.org/works/10.1007%2FS00280-011-1661-5

21 January 2018

A simple and sensitive fully validated HPLC-UV method for the determination of 5-fluorouracil and its metabolite 5,6-dihydrofluorouracil in plasma

1 reference

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21 January 2018

Review on pharmacokinetics and pharmacodynamics and the aging kidney

1 reference

https://api.crossref.org/works/10.1007%2FS00280-011-1661-5

21 January 2018

Extensive hepatic replacement due to liver metastases has no effect on 5-fluorouracil pharmacokinetics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220818

26 September 2018

Measurement of plasma uracil using gas chromatography-mass spectrometry in normal individuals and in patients receiving inhibitors of dihydropyrimidine dehydrogenase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220818

26 September 2018

Cyclophosphamide and fluorouracil combined with mitoxantrone versus doxorubicin for breast cancer: superiority of doxorubicin.

1 reference

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26 September 2018

Disease-free survival advantage of adjuvant cyclophosphamide, methotrexate, and fluorouracil in patients with node-negative, rapidly proliferating breast cancer: a randomized multicenter study

1 reference

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15 November 2018

Correlation between uracil and dihydrouracil plasma ratio, fluorouracil (5-FU) pharmacokinetic parameters, and tolerance in patients with advanced colorectal cancer: A potential interest for predicting 5-FU toxicity and determining optimal 5-FU dosa

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pitfalls in the diagnosis of patients with a partial dihydropyrimidine dehydrogenase deficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/21590448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simple and sensitive determination of 5-fluorouracil in plasma by high-performance liquid chromatography. Application to clinical pharmacokinetic studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/21590448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical implications of dihydropyrimidine dehydrogenase (DPD) deficiency in patients with severe 5-fluorouracil-associated toxicity: identification of new mutations in the DPD gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/21590448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infus

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlation between dihydropyrimidine dehydrogenase activity in peripheral mononuclear cells and systemic clearance of fluorouracil in cancer patients

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Population study of dihydropyrimidine dehydrogenase in cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/21590448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A pharmacokinetic-based test to prevent severe 5-fluorouracil toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21590448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A rapid and inexpensive method for anticipating severe toxicity to fluorouracil and fluorouracil-based chemotherapy

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The dihydrouracil/uracil ratios in plasma and toxicities of 5-fluorouracil-based adjuvant chemotherapy in colorectal cancer patients

1 reference

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12 December 2020

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inferred from PubMed ID database lookup

Identifiers

10.1007/S00280-011-1661-5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21590448%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21590448%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

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1 February 2020

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