The salivary secretome of the tsetse fly Glossina pallidipes (Diptera: Glossinidae) infected by salivary gland hypertrophy virus. (Q35568801)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22132244%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

title

The salivary secretome of the tsetse fly Glossina pallidipes (Diptera: Glossinidae) infected by salivary gland hypertrophy virus (English)

1 reference

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17 January 2020

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1 reference

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Glossinidae

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1

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17 January 2020

Adly Abd-alla

4

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17 January 2020

Serap Aksoy

6

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17 January 2020

7

Just M Vlak

1 reference

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17 January 2020

author name string

Ikbal A Ince

2

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17 January 2020

Sjef Boeren

3

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17 January 2020

Andrew G Parker

5

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17 January 2020

Monique M van Oers

8

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17 January 2020

language of work or name

English

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publication date

22 November 2011

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PLoS Neglected Tropical Diseases

17 January 2020

published in

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17 January 2020

volume

5

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17 January 2020

issue

11

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17 January 2020

page(s)

e1371

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Creative Commons Attribution 4.0 International

17 January 2020

copyright license

start time

22 November 2011

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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A peptide with similarity to baculovirus ODV-E66 binds the gut epithelium of Heliothis virescens and impedes infection with Autographa californica multiple nucleopolyhedrovirus

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Identification of a tsetse fly salivary protein with dual inhibitory action on human platelet aggregation

12 July 2018

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12 July 2018

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12 July 2018

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MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

12 July 2018

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Epstein-Barr virus nuclear antigen (EBNA) 3A induces the expression of and interacts with a subset of chaperones and co-chaperones.

12 July 2018

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12 July 2018

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Genome analysis of a Glossina pallidipes salivary gland hypertrophy virus reveals a novel, large, double-stranded circular DNA virus

12 July 2018

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Cellular proteasome activity facilitates herpes simplex virus entry at a postpenetration step

12 July 2018

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Proteolytic cleavage of VP1-2 is required for release of herpes simplex virus 1 DNA into the nucleus

12 July 2018

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The role of hemocytes, serine protease inhibitors and pathogen-associated patterns in prophenoloxidase activation in the desert locust, Schistocerca gregaria

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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The Glossina morsitans tsetse fly saliva: general characteristics and identification of novel salivary proteins.

12 July 2018

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12 July 2018

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12 July 2018

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Tsetse fly saliva accelerates the onset of Trypanosoma brucei infection in a mouse model associated with a reduced host inflammatory response

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Evidence for proteolytic cleavage of the baculovirus occlusion-derived virion envelope protein P74.

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Cytoplasmic dynein mediates adenovirus binding to microtubules

12 July 2018

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SRC mediates a switch from microtubule- to actin-based motility of vaccinia virus

12 July 2018

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The Heliothis armigera single nucleocapsid nucleopolyhedrovirus envelope protein P74 is required for infection of the host midgut

12 July 2018

1 reference

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12 July 2018

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12 July 2018

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12 July 2018

1 reference

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12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

P74 mediates specific binding of Autographa californica M nucleopolyhedrovirus occlusion-derived virus to primary cellular targets in the midgut epithelia of Heliothis virescens Larvae

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

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12 July 2018

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The mechanisms of lipid-protein rearrangements during viral infection

12 July 2018

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Deletion of the Autographa californica nucleopolyhedrovirus chitinase KDEL motif and in vitro and in vivo analysis of the modified virus

12 July 2018

1 reference

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12 July 2018

1 reference

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Thioester-containing proteins and insect immunity

12 July 2018

1 reference

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12 July 2018

1 reference

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Novel Partner Proteins of Adenovirus Penton

12 July 2018

1 reference

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Human cytomegalovirus infection induces cellular thymidylate synthase gene expression in quiescent fibroblasts

12 July 2018

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Intact microtubules support adenovirus and herpes simplex virus infections

12 July 2018

1 reference

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Break ins and break outs: viral interactions with the cytoskeleton of Mammalian cells.

12 July 2018

1 reference

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Signalling in viral entry

12 July 2018

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Heat shock cognate protein 70 is involved in rotavirus cell entry

12 July 2018

1 reference

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DNA viruses and viral proteins that interact with PML nuclear bodies

12 July 2018

1 reference

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12 July 2018

1 reference

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A study of the Autographa californica multiple nucleopolyhedrovirus ODV envelope protein p74 using a GFP tag.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Drug resistance in Trypanosoma brucei spp., the causative agents of sleeping sickness in man and nagana in cattle

12 July 2018

1 reference

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Roles of the heat shock transcription factors in regulation of the heat shock response and beyond

12 July 2018

1 reference

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Complement. First of two parts

12 July 2018

1 reference

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Adenovirus-activated PKA and p38/MAPK pathways boost microtubule-mediated nuclear targeting of virus

12 July 2018

1 reference

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Characterization of genes expressed in the salivary glands of the tsetse fly, Glossina morsitans morsitans.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

A family of genes with growth factor and adenosine deaminase similarity are preferentially expressed in the salivary glands of Glossina m. morsitans

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Murine cytomegalovirus stimulates cellular thymidylate synthase gene expression in quiescent cells and requires the enzyme for replication

12 July 2018

1 reference

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Bacillus thuringiensis crystal delta-endotoxin: role of proteases in the conversion of protoxin to toxin

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Nuclear import of adenovirus DNA in vitro involves the nuclear protein import pathway and hsc70.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Heat shock factors and the control of the stress response

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Expression of a chitinase gene and lysis of the host cell wall during Chlorella virus CVK2 infection

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Microtubule-dependent plus- and minus end-directed motilities are competing processes for nuclear targeting of adenovirus

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

A glycosyl hydrolase activity of mammalian reovirus sigma1 protein can contribute to viral infection through a mucus layer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

A viral activator of gene expression functions via the ubiquitin-proteasome pathway

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Tsetse thrombin inhibitor: bloodmeal-induced expression of an anticoagulant in salivary glands and gut tissue of Glossina morsitans morsitans

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Analysis of p74, a PDV envelope protein of Autographa californica nucleopolyhedrovirus required for occlusion body infectivity in vivo

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Innate immunity: impact on the adaptive immune response

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Ultrastructural Changes in the Milk Gland of Tsetse Glossina morsitans centralis (Diptera; Glissinidae) Female Infected by a DNA Virus

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Novel exploitation of a nuclear function by influenza virus: the cellular SF2/ASF splicing factor controls the amount of the essential viral M2 ion channel protein in infected cells.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Oncogenic potential of the adenovirus E4orf6 protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Structural classification of HTH DNA-binding domains and protein-DNA interaction modes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Human cytomegalovirus immediate-early 2 (IE2) protein can transactivate the human hsp70 promoter by alleviation of Dr1-mediated repression

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Molecular chaperones in cellular protein folding

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumor suppressor

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Nuclear domain 10 as preexisting potential replication start sites of herpes simplex virus type-1.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Human cytomegalovirus immediate-early gene 2 protein interacts with itself and with several novel cellular proteins

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Functional interaction between the HCMV IE2 transactivator and the retinoblastoma protein.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Eukaryotic translation elongation factor 1 gamma contains a glutathione transferase domain--study of a diverse, ancient protein superfamily using motif search and structural modeling

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

The Growth Transformation of Human B Cells Involves Superinduction of hsp70 and hsp90

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Subcellular distribution of viral structural proteins during simian virus 40 infection

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Sources of larval salivary gland secretion in the dipteran Chironomus tentans

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Gonadal lesions in virus-infected male and female tsetse, Glossina pallidipes (Diptera: Glossinidae)

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Binding of polyomavirus large T antigen to the human hsp70 promoter is not required for trans activation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Restriction endonuclease activity induced by PBCV-1 virus infection of a Chlorella-like green alga

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

The 70-kd mammalian heat shock proteins are structurally and functionally related to the uncoating protein that releases clathrin triskelia from coated vesicles

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Definition of multiple, functionally distinct TATA elements, one of which is a target in the hsp70 promoter for E1A regulation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Approaching the asymptote? Evolution and revolution in immunology

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Characterization of the salivary apyrase activity of three rodent flea species

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

The cellular functions of small GTP-binding proteins

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

ADP-ribosylation factor is functionally and physically associated with the Golgi complex

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Dissociation of clathrin from coated vesicles by the uncoating ATPase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Class II (B) general transcription factor (TFIIB) that binds to the template-committed preinitiation complex is different from general transcription factor BTF3.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Analysis of the specificity and mechanism of transcriptional activation of the human hsp70 gene during infection by DNA viruses

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Adenovirus capsid proteins interact with HSP70 proteins after penetration in human or rodent cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Protein folding in the cell: the role of molecular chaperones Hsp70 and Hsp60

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Human cytomegalovirus US3 and UL36-38 immediate-early proteins regulate gene expression

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Virus-like rods associated with salivary gland hyperplasia in tsetse, Glossina pallidipes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Effects of External and Internal Arthropod Parasites on Domestic Livestock Production

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Vector competence of Glossina palpalis gambiensis for Trypanosoma brucei s.l. and genetic diversity of the symbiont Sodalis glossinidius

12 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001371

The rise and fall of sleeping sickness

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001371

Dynamics of the salivary gland hypertrophy virus in laboratory colonies of Glossina pallidipes (Diptera: Glossinidae).

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001371

Development of a non-destructive PCR method for detection of the salivary gland hypertrophy virus (SGHV) in tsetse flies

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001371

Universal primers for rapid detection of hytrosaviruses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001371

The major acid soluble proteins of adult female Anopheles darlingi salivary glands include a member of the D7-related family of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001371

Proteomic analysis of Chilo iridescent virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001371

Proteomic analysis of Glossina pallidipes salivary gland hypertrophy virus virions for immune intervention in tsetse fly colonies

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001371

Sequences annotated by structure: a tool to facilitate the use of structural information in sequence analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001371

Quantitative PCR analysis of the salivary gland hypertrophy virus (GpSGHV) in a laboratory colony of Glossina pallidipes

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001371

The secreted salivary proteome of the pea aphid Acyrthosiphon pisum characterised by mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001371

The C-type lectin superfamily in the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001371

Characterization of two novel ADP ribosylation factors from the shrimp Marsupenaeus japonicus

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001371

Molecular cloning and characterization of a class II ADP ribosylation factor from the shrimp Marsupenaeus japonicus

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001371

Junctional gating: the achilles' heel of epithelial cells in pathogen infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001371

The role of ABCE1 in eukaryotic posttermination ribosomal recycling

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001371

The nuclear location of PML, a cellular member of the C3HC4 zinc-binding domain protein family, is rearranged during herpes simplex virus infection by the C3HC4 viral protein ICP0.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001371

Parallel changes in host resistance to viral infection during 45,000 generations of relaxed selection.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Metabolic changes in diseased insects. 3. Nucleic acid metabolism in Lepidoptera infected by densonucleosis and Tipula iridescent viruses

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222630

Characterization of the salivary apyrase activity of three rodent flea species

26 September 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001371

The human cytomegalovirus 86K immediate early (IE) 2 protein requires the basic region of the TATA-box binding protein (TBP) for binding, and interacts with TBP and transcription factor TFIIB via regions of IE2 required for transcriptional regulatio

21 January 2018

1 reference

12 December 2020

Chaperones and transcriptional regulation by nuclear receptors

1 reference

12 December 2020

Stress-inducible responses and heat shock proteins: new pharmacologic targets for cytoprotection

1 reference

12 December 2020

Chaperone properties of bacterial elongation factor EF-G and initiation factor IF2

1 reference

12 December 2020

Translational regulation of deoxycytidylate hydroxymethylase and deoxynucleotide kinase synthesis in T4-infected Escherichia coli

1 reference

12 December 2020

Stepwise dismantling of adenovirus 2 during entry into cells

1 reference

12 December 2020

10.1371/JOURNAL.PNTD.0001371

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22132244%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22132244%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

PubMed publication ID

22132244

1 reference