Valproic acid and butyrate induce apoptosis in human cancer cells through inhibition of gene expression of Akt/protein kinase B (Q35568845)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17156483%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

title

Valproic acid and butyrate induce apoptosis in human cancer cells through inhibition of gene expression of Akt/protein kinase B (English)

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22 December 2019

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ChEBI release 2020-05-28

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1

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22 December 2019

Qiao Li

series ordinal

4

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22 December 2019

2

Feras M Ghazawi

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22 December 2019

author name string

Wafae Bakkar

series ordinal

3

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22 December 2019

publication date

11 December 2006

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22 December 2019

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22 December 2019

volume

5

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22 December 2019

page(s)

71

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Histone acetylation-independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphatase 1 complexes

22 December 2019

cites work

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Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species

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B56 regulatory subunit of protein phosphatase 2A mediates valproic acid-induced p300 degradation

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12 July 2018

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

12 July 2018

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Worms gang up on bacteria

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12 July 2018

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Ten years of protein kinase B signalling: a hard Akt to follow

12 July 2018

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AKT plays a central role in tumorigenesis

12 July 2018

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Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen

12 July 2018

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Akt regulates cell survival and apoptosis at a postmitochondrial level

12 July 2018

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Acetylation: a regulatory modification to rival phosphorylation?

12 July 2018

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Cellular survival: a play in three Akts

12 July 2018

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The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.

12 July 2018

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p300 stimulates transcription instigated by ligand-bound thyroid hormone receptor at a step subsequent to chromatin disruption

12 July 2018

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NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

12 July 2018

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NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

12 July 2018

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Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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n-Butyrate causes histone modification in HeLa and Friend erythroleukaemia cells

12 July 2018

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Histone deacetylase inhibitors, N-butyric acid and trichostatin A, induce caspase-8- but not caspase-9-dependent apoptosis in human malignant glioma cells

12 July 2018

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Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members

26 September 2018

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Simultaneous activation of the intrinsic and extrinsic pathways by histone deacetylase (HDAC) inhibitors and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) synergistically induces mitochondrial damage and apoptosis in human leukemia

26 September 2018

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Cotreatment with the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) enhances imatinib-induced apoptosis of Bcr-Abl-positive human acute leukemia cells

26 September 2018

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26 September 2018

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26 September 2018

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26 September 2018

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12 December 2020

Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway

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12 December 2020

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12 December 2020

Identifiers

DOI

10.1186/1476-4598-5-71

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17156483%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

22 December 2019

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17156483%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

PubMed publication ID

17156483

1 reference