Exaggerated NMDA mediated LTD in a mouse model of Down syndrome and pharmacological rescuing by memantine (Q35569636)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22101180%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

title

Exaggerated NMDA mediated LTD in a mouse model of Down syndrome and pharmacological rescuing by memantine (English)

1 reference

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17 January 2020

1 reference

1

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17 January 2020

Alberto C Costa

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22101180%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

author name string

Jonah J Scott-McKean

series ordinal

1

1 reference

PubMed ID

22101180

8 August 2017

Alberto C S Costa

series ordinal

2

1 reference

8 August 2017

18 November 2011

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17 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22101180%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

volume

18

1 reference

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17 January 2020

issue

12

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17 January 2020

page(s)

774-778

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On the promise of pharmacotherapies targeted at cognitive and neurodegenerative components of Down syndrome

17 January 2020

cites work

1 reference

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27 July 2018

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27 July 2018

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Effects of long-term memantine on memory and neuropathology in Ts65Dn mice, a model for Down syndrome

27 July 2018

1 reference

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Molecular basis of pharmacotherapies for cognition in Down syndrome

27 July 2018

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Behavioral validation of the Ts65Dn mouse model for Down syndrome of a genetic background free of the retinal degeneration mutation Pde6b(rd1).

27 July 2018

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Normal protein composition of synapses in Ts65Dn mice: a mouse model of Down syndrome

27 July 2018

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Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK-801.

27 July 2018

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The fragile X prevalence paradox

27 July 2018

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Altered expression of KIF17, a kinesin motor protein associated with NR2B trafficking, may mediate learning deficits in a Down syndrome mouse model

27 July 2018

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National estimates and race/ethnic-specific variation of selected birth defects in the United States, 1999-2001.

27 July 2018

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Pharmacokinetic study of memantine in healthy and renally impaired subjects

27 July 2018

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Dynamin-dependent NMDAR endocytosis during LTD and its dependence on synaptic state

27 July 2018

1 reference

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Deficits in hippocampal CA1 LTP induced by TBS but not HFS in the Ts65Dn mouse: a model of Down syndrome.

27 July 2018

1 reference

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Down syndrome and genetics - a case of linked histories.

27 July 2018

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Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome.

27 July 2018

1 reference

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The mGluR theory of fragile X mental retardation

27 July 2018

1 reference

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Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia

27 July 2018

1 reference

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AMPA receptor trafficking and synaptic plasticity

27 July 2018

1 reference

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Altered synaptic plasticity in a mouse model of fragile X mental retardation

27 July 2018

1 reference

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Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome

27 July 2018

1 reference

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Excitatory synaptic transmission mediated by NMDA receptors is more sensitive to isoflurane than are non-NMDA receptor-mediated responses

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222894

Aminoadamantanes as NMDA receptor antagonists and antiparkinsonian agents--preclinical studies.

27 July 2018

1 reference

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Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222894

A mouse model for Down syndrome exhibits learning and behaviour deficits.

27 July 2018

1 reference

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Variation of the CGG repeat at the fragile X site results in genetic instability: Resolution of the Sherman paradox

27 July 2018

1 reference

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Memantine normalizes several phenotypic features in the Ts65Dn mouse model of Down syndrome.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222894

Increased NR2A expression and prolonged decay of NMDA-induced calcium transient in cerebellum of TgDyrk1A mice, a mouse model of Down syndrome.

26 September 2018

1 reference

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Acute injections of the NMDA receptor antagonist memantine rescue performance deficits of the Ts65Dn mouse model of Down syndrome on a fear conditioning test.

26 September 2018

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Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome.

26 September 2018

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Distinct triggering and expression mechanisms underlie LTD of AMPA and NMDA synaptic responses.

26 September 2018

1 reference

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26 September 2018

1 reference

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Motor dysfunction in a mouse model for Down syndrome.

26 September 2018

1 reference

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Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome.

26 September 2018

1 reference

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Independent mechanisms for long-term depression of AMPA and NMDA responses

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222894

Regulation of NMDA channel function by endogenous Ca(2+)-dependent phosphatase

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3222894

Cerebrospinal fluid and serum concentrations of the N-methyl-D-aspartate (NMDA) receptor antagonist memantine in man.

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22101180

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1101/LM.024182.111

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22101180%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22101180%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference