Inhibitors of DNA methylation in the treatment of hematological malignancies and MDS. (Q35571293)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585280%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

review article

1 reference

title

Inhibitors of DNA methylation in the treatment of hematological malignancies and MDS (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585280%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585280%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

Maria T Voso

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585280%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

Luciana Teofili

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585280%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

author name string

Michael Lübbert

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585280%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

language of work or name

1 reference

1 October 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585280%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585280%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

volume

109

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585280%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585280%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

page(s)

89-102

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585280%20AND%20SRC:MED&resulttype=core&format=json

Cancer epigenetics comes of age

20 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

DNA hypermethylation in tumorigenesis: epigenetics joins genetics

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Chromosomal Instability and Tumors Promoted by DNA Hypomethylation

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Induction of Tumors in Mice by Genomic Hypomethylation

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Interleukin-3 increases the incidence of 5-azacytidine-induced thymic lymphomas in pBOR-Il-3 mice

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Novel methylation targets in de novo acute myeloid leukemia with prevalence of chromosome 11 loci

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Methylation profiling in acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Alterations of DNA methylation in hematologic malignancies

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Expression of cyclin-dependent kinase inhibitor p15(INK4B) during normal and leukemic myeloid differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

A cell cycle regulator potentially involved in genesis of many tumor types

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

CDKN2 (MTS1/p16INK4A) gene alterations in hematological malignancies

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Methylation of the p15(INK4B) gene in myelodysplastic syndrome: it can be detected early at diagnosis or during disease progression and is highly associated with leukaemic transformation

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Gene silencing of the p15/INK4B cell-cycle inhibitor by hypermethylation: an early or later epigenetic alteration in myelodysplastic syndromes?

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Microsatellite instability occurs in defined subsets of patients with acute myeloblastic leukaemia

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Drug treatment in the development of mismatch repair defective acute leukemia and myelodysplastic syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Methylation of the hMLH1 promoter and its association with microsatellite instability in acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Aberrant p15 gene promoter methylation in therapy-related myelodysplastic syndrome and acute myeloid leukaemia: clinicopathological and karyotypic associations

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Progressive de novo DNA methylation at the bcr-abl locus in the course of chronic myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Genomic p16 abnormalities in the progression of chronic myeloid leukemia into blast crisis

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Detection of methylated ABL1 promoter in philadelphia-negative myeloproliferative disorders.

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

JunB gene expression is inactivated by methylation in chronic myeloid leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Methylation of p15 and p16 genes in acute promyelocytic leukemia: potential diagnostic and prognostic significance

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Hypermethylation of GpG islands in the promoter region of p15(INK4b) in acute promyelocytic leukemia represses p15(INK4b) expression and correlates with poor prognosis.

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Aberrant DNA methylation in pediatric patients with acute lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Methylation analysis of cell cycle control genes in adult T-cell leukemia/lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Hypermethylation of P16ink4a and P15ink4b genes as a marker of disease in the follow-up of non-Hodgkin's lymphomas

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Different incidence and pattern of p15INK4b and p16INK4a promoter region hypermethylation in Hodgkin's and CD30-Positive non-Hodgkin's lymphomas

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Inactivation of tumor suppressor genes p15(INK4b) and p16(INK4a) in primary cutaneous B cell lymphoma.

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Regression of low-grade gastric mucosa-associated lymphoid tissue lymphoma after eradication of Helicobacter pylori: possible association with p16 hypermethylation

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Role of genetic and epigenetic changes in Burkitt lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Alterations of the cyclin D1/pRb/p16(INK4A) pathway in multiple myeloma

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Methylation is an inactivating mechanism of the p16 gene in multiple myeloma associated with high plasma cell proliferation and short survival

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Aberrant DNA methylation of p57(KIP2) gene in the promoter region in lymphoid malignancies of B-cell phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Down-regulation of candidate tumor suppressor genes within chromosome band 13q14.3 is independent of the DNA methylation pattern in B-cell chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Microsatellite instability and hMLH1 promoter hypermethylation in Richter's transformation of chronic lymphocytic leukemia.

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

DNA methylation as a target for drug design

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2'-deoxycytidine (decitabine) treatment

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Expression of p15(ink4b) gene during megakaryocytic differentiation of normal and myelodysplastic hematopoietic progenitors.

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Preclinical evaluation of antineoplastic activity of inhibitors of DNA methylation (5-aza-2'-deoxycytidine) and histone deacetylation (trichostatin A, depsipeptide) in combination against myeloid leukemic cells

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repair

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Cytogenetic responses in high-risk myelodysplastic syndrome following low-dose treatment with the DNA methylation inhibitor 5-aza-2'-deoxycytidine

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Phase I study of arabinosyl-5-azacytidine (fazarabine) in adult acute leukemia and chronic myelogenous leukemia in blastic phase

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Changes in phenotypic expression in embryonic and adult cells treated with 5-azacytidine

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Molecular, cellular and animal pharmacology of 5-aza-2'-deoxycytidine

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

DNA methyltransferases

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Towards a pharmacology of DNA methylation

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

DNA methyltransferase Dnmt1 associates with histone deacetylase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Evaluation of continuous infusion low-dose 5-azacytidine in the treatment of myelodysplastic syndromes

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B.

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Impact of azacytidine on the quality of life of patients with myelodysplastic syndrome treated in a randomized phase III trial: a Cancer and Leukemia Group B study

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Continuous infusion of low-dose 5-Aza-2'-deoxycytidine in elderly patients with high-risk myelodysplastic syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Low-dose 5-aza-2'-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: a multicenter phase II study in elderly patients

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Hypocellular myelodysplastic syndromes (MDS): new proposals.

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Chronic myelogenous leukemia in nonlymphoid blastic phase: analysis of the results of first salvage therapy with three different treatment approaches for 162 patients.

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Cytostatic activity of phenylacetate and derivatives against tumor cells. Correlation with lipophilicity and inhibition of protein prenylation

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Synergistic interactions between differentiation-inducing agents in inhibiting the proliferation of HL-60 human myeloid leukaemia cells in clonogenic micro assays

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900207-9

7 January 2021

10.1016/S1521-6616(03)00207-9

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14585280%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

1 reference