DNA methylation as a target for drug design (Q41730013)

8 October 2017

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title

DNA methylation as a target for drug design (English)

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8 October 2017

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Bender CM

1

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PubMed ID

9523301

8 October 2017

Zingg JM

series ordinal

2

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PubMed ID

9523301

8 October 2017

Jones PA

series ordinal

3

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8 October 2017

1 February 1998

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8 October 2017

Pharmaceutical Research

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8 October 2017

15

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8 October 2017

2

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8 October 2017

175-187

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DNA methylation and genetic instability in colorectal cancer cells

8 October 2017

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12 December 2020

Cell proliferation and global methylation status changes in mouse liver after phenobarbital and/or choline-devoid, methionine-deficient diet administration.

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12 December 2020

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis

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12 December 2020

Inhibition of in vitro tumor cell invasion by transmethylation inhibitors

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12 December 2020

Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation.

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12 December 2020

Differential nuclear protein binding to 5-azacytosine-containing DNA as a potential mechanism for 5-aza-2'-deoxycytidine resistance

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12 December 2020

Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells

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12 December 2020

Cellular differentiation, cytidine analogs and DNA methylation

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12 December 2020

Cell cycle effects and cellular pharmacology of 5-AZA-2?-deoxycytidine

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12 December 2020

Tissue levels of S-adenosylmethionine and S-adenosylhomocysteine in rats fed methyl-deficient, amino acid-defined diets for one to five weeks.

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12 December 2020

In vitro methylation of the hamster adenine phosphoribosyltransferase gene inhibits its expression in mouse L cells

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12 December 2020

Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53.

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12 December 2020

Substrate and sequence specificity of a eukaryotic DNA methylase

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12 December 2020

Effects of S-adenosylhomocysteine and analogs on Epstein-Barr virus-induced transformation, expression of the Epstein-Barr virus capsid antigen, and methylation of Epstein-Barr virus DNA.

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12 December 2020

Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs.

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12 December 2020

DNA methylation errors and cancer.

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12 December 2020

S-adenosylhomocysteine hydrolase inhibitors as broad-spectrum antiviral agents

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12 December 2020

Effects of DNA methylation on DNA-binding proteins and gene expression.

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12 December 2020

Reduced genomic 5-methylcytosine content in human colonic neoplasia

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12 December 2020

Hereditary cancers of man

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12 December 2020

Structural and conformational analogues of L-methionine as inhibitors of the enzymatic synthesis of S-adenosyl-L-methionine. IV. Further mono-, bi- and tricyclic amino acids

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12 December 2020

A direct demonstration of somatically paired heterochromatin of human chromosomes

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12 December 2020

In vitro cytotoxic and biochemical effects of 5-aza-2'-deoxycytidine

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12 December 2020

Mutagenicity of 5-aza-2'-deoxycytidine is mediated by the mammalian DNA methyltransferase

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12 December 2020

DNA methylation and polyamines in embryonic development and cancer.

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12 December 2020

Correlation between Hypomethylation of DNA and Expression of Globin Genes in Friend Erythroleukemia Cells

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12 December 2020

DNA methyltransferase levels in tumorigenic and nontumorigenic cells in culture

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12 December 2020

Molecular and cytological evidence of S-adenosyl-L-homocysteine as an innocuous undermethylating agent in vivo

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12 December 2020

5-Azacytidine-induced undercondensations in human chromosomes

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12 December 2020

The estrogen receptor CpG island is methylated in most hematopoietic neoplasms.

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12 December 2020

Molecular forms of chicken embryo acetylcholinesterase in vitro and in vivo. Isolation and characterization

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12 December 2020

Isolation and characterization of DNA cytosine 5-methyltransferase from human placenta

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12 December 2020

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers

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12 December 2020

Structural and conformational analogues of L-methionine as inhibitors of the enzymatic synthesis of S-adenosyl-l-methionine. 3. Carbocyclic and heterocyclic amino acids

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12 December 2020

The modulation of the thymidine triphosphate pool of Chinese hamster cells by dCMP deaminase and UDP reductase. Thymidine auxotrophy induced by CTP in dCMP deaminase-deficient lines

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12 December 2020

Hemimethylated duplex DNAs prepared from 5-azacytidine-treated cells

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12 December 2020

High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines.

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12 December 2020

Kinetics of phosphorylation of 5-aza-2′-deoxycytidine by deoxycytidine kinase

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12 December 2020

Expression of antisense to DNA methyltransferase mRNA induces DNA demethylation and inhibits tumorigenesis

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12 December 2020

Reversibility of changes in nucleic acid methylation and gene expression induced in rat liver by severe dietary methyl deficiency.

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12 December 2020

The flip side of DNA methylation

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12 December 2020

Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B.

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12 December 2020

De novo methylation of the MyoD1 CpG island during the establishment of immortal cell lines

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12 December 2020

HhaI methyltransferase flips its target base out of the DNA helix

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12 December 2020

Cytosine deaminations catalyzed by DNA cytosine methyltransferases are unlikely to be the major cause of mutational hot spots at sites of cytosine methylation in Escherichia coli

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12 December 2020

Clinical trial on 5-aza-2'-deoxycytidine in patients with acute leukemia

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12 December 2020

Hypermethylation of the p16 gene in nasopharyngeal carcinoma

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12 December 2020

Induction of HL-60 cell differentiation by 3-deaza-(+/-)-aristeromycin, an inhibitor of S-adenosylhomocysteine hydrolase

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12 December 2020

Methylation of the BRCA1 gene in sporadic breast cancer

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12 December 2020

Structure and function of DNA methyltransferases.

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12 December 2020

Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide

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12 December 2020

Ubiquitous and tenacious methylation of the CpG site in codon 248 of the p53 gene may explain its frequent appearance as a mutational hot spot in human cancer

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12 December 2020

Determination of the order of substrate addition to MspI DNA methyltransferase using a novel mechanism-based inhibitor

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12 December 2020

Heat-induced deamination of cytosine residues in deoxyribonucleic acid

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12 December 2020

Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidine and 5-aza-2'-deoxycytidine

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12 December 2020

5-Aza-2'-deoxycytidine (Decitabine) and 5-azacytidine in the treatment of acute myeloid leukemias and myelodysplastic syndromes: past, present and future trends

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12 December 2020

Mutagenic and epigenetic effects of DNA methylation

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12 December 2020

Structural and conformational analogues of L-methionine as inhibitors of the enzymatic synthesis of S-adenosyl-L-methionine. II. Aromatic amino acids

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12 December 2020

DNA methyltransferases

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12 December 2020

Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing

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12 December 2020

Differentiation of Two Mouse Cell Lines Is Associated with Hypomethylation of Their Genomes

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12 December 2020

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

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12 December 2020

Combined modulation of S-adenosylmethionine biosynthesis and S-adenosylhomocysteine metabolism enhances inhibition of nucleic acid methylation and L1210 cell growth

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12 December 2020

Abnormal patterns of DNA methylation in human neoplasia: potential consequences for tumor progression

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12 December 2020

Antileukemic effects of pseudoisocytidine, a new synthetic pyrimidine C-nucleoside

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12 December 2020

4'-Thioadenosine as a novel inhibitor of S-adenosylhomocysteine hydrolase and an inducer for the differentiation of HL-60 human leukemia cells.

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12 December 2020

Properties of L1210 cells resistant to alpha-difluoromethylornithine

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12 December 2020

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12 December 2020

On the mechanism and inhibition of DNA cytosine methyltransferases

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12 December 2020

The mechanism of inhibition of DNA (cytosine-5-)-methyltransferases by 5-azacytosine is likely to involve methyl transfer to the inhibitor

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12 December 2020

Choline deficiency and methotrexate treatment induces marked but reversible changes in hepatic folate concentrations, serum homocysteine and DNA methylation rates in rats

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12 December 2020

Chemotherapy of L1210 and L1210/ARA-C leukemia with 5-aza-2'-deoxycytidine and 3-deazauridine.

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12 December 2020

Cytotoxicity and mode of action of 5-azacytidine on L1210 leukemia

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12 December 2020

Effect of schedule and combinations on clinical effectiveness of Ara-C in adult acute leukemia

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12 December 2020

Establishment of methylation-sensitive-representational difference analysis and isolation of hypo- and hypermethylated genomic fragments in mouse liver tumors

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12 December 2020

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma

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12 December 2020

S-Adenosyl-L-methionine-dependent macromolecule methyltransferases: potential targets for the design of chemotherapeutic agents

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12 December 2020

Interference with polyamine biosynthesis and/or function by analogs of polyamines or methionine as a potential anticancer chemotherapeutic strategy.

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12 December 2020

Synthesis and biological activity of sinefungin analogues

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12 December 2020

Methylation, mutation and cancer

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12 December 2020

Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation

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12 December 2020

Effect of thymidine on the sensitivity of cultured mouse tumor cells to 1-beta-D-arabinofuranosylcytosine

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12 December 2020

Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma

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12 December 2020

De novo methylation and expression of retroviral genomes during mouse embryogenesis.

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12 December 2020

Inhibition of DNA methylation by 5-aza-2'-deoxycytidine suppresses the growth of human tumor cell lines

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12 December 2020

Polyamines: from molecular biology to clinical applications

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12 December 2020

Phase I study on 5-aza-2′-deoxycytidine in children with acute leukemia

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12 December 2020

Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

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12 December 2020

Methylation of the 5' CpG island of the endothelin B receptor gene is common in human prostate cancer.

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12 December 2020

Imprinting of human H19: allele-specific CpG methylation, loss of the active allele in Wilms tumor, and potential for somatic allele switching

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12 December 2020

Methyl-donor deficiency due to chemically induced glutathione depletion

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12 December 2020

Demethylation of the estrogen receptor gene in estrogen receptor-negative breast cancer cells can reactivate estrogen receptor gene expression.

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12 December 2020

5-Azacytidine: a new active agent for the treatment of acute leukemia

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12 December 2020

Methylation of the estrogen receptor CpG island in lung tumors is related to the specific type of carcinogen exposure

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12 December 2020

The DNA (cytosine-5) methyltransferases

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12 December 2020

CpG islands in vertebrate genomes

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12 December 2020

Analogues of methionine as substrates and inhibitors of the methionine adenosyltransferase reaction. Deductions concerning the conformation of methionine

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12 December 2020

5-AZA-2′-deoxycytidine therapy in patients with acute leukemia inhibits DNA methylation

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12 December 2020

Molecular, cellular and animal pharmacology of 5-aza-2'-deoxycytidine

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12 December 2020

Mutagenic deamination of cytosine residues in DNA

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12 December 2020

Effect of several inhibitors of enzymatic DNA methylation on thein vivomethylation of different classes of DNA sequences in a cultured human cell line

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12 December 2020

Synergistic action of 5-aza-2'-deoxycytidine and 3-deazauridine on L1210 leukemic cells and EMT6 tumor cells

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12 December 2020

Multiple new phenotypes induced in and 3T3 cells treated with 5-azacytidine

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12 December 2020

On the mechanism of inhibition of DNA-cytosine methyltransferases by cytosine analogs

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12 December 2020

Folate, Methionine, and Alcohol Intake and Risk of Colorectal Adenoma

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12 December 2020

High-performance Liquid Chromatographic Analysis of Chemical Stability of 5-aza-2′-Deoxycytidine

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12 December 2020

HhaI and HpaII DNA methyltransferases bind DNA mismatches, methylate uracil and block DNA repair

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12 December 2020

Hypermethylation of the 5' region of the calcitonin gene is a property of human lymphoid and acute myeloid malignancies

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12 December 2020

Enhancement of the antileukemic activity of 5-aza-2'-deoxycytidine by cyclopentenyl cytosine in HL-60 leukemic cells

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12 December 2020

Hypermethylation of the myogenic gene Myf-3 in human breast carcinomas

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12 December 2020

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

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12 December 2020

DNA Methylation and Gene Function

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12 December 2020

De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells

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12 December 2020

Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development

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12 December 2020

Complete and tissue-independent methylation of CpG sites in the p53 gene: implications for mutations in human cancers.

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12 December 2020

Methylation inhibitors can increase the rate of cytosine deamination by (cytosine-5)-DNA methyltransferase

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12 December 2020

Genetic and epigenetic aspects of DNA methylation on genome expression, evolution, mutation and carcinogenesis

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12 December 2020

High frequency mutagenesis by a DNA methyltransferase

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12 December 2020

DNA methylation and gene activity

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12 December 2020

5-Azacytidine. A new anticancer drug with effectiveness in acute myelogenous leukemia

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12 December 2020

The rate of hydrolytic deamination of 5-methylcytosine in double-stranded DNA

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12 December 2020

Correlation between S-adenosyl-L-methionine content and production of c-myc, c-Ha-ras, and c-Ki-ras mRNA transcripts in the early stages of rat liver carcinogenesis.

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12 December 2020

Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene

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12 December 2020

Pharmacological approach for optimization of the dose schedule of 5-Aza-2'-deoxycytidine (Decitabine) for the therapy of leukemia

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12 December 2020

The essentials of DNA methylation

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12 December 2020

Deoxycytidylate Aminohydrolase. II. Kinetic Properties. The Activatory Effect of Deoxycytidine Triphosphate and the Inhibitory Effect of Deoxythymidine Triphosphate*

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12 December 2020

Effect of trna from 5-azacytidine-treated hamster fibrosarcoma cells on protein synthesis in vitro in a cell-free system

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12 December 2020

Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is sufficient to cause a lupus-like disease in syngeneic mice

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12 December 2020

Two DNA methyltransferases from murine erythroleukemia cells: purification, sequence specificity, and mode of interaction with DNA.

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12 December 2020

The irreversible binding of azacytosine-containing DNA fragments to bacterial DNA(cytosine-5)methyltransferases

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12 December 2020

Cytosine methylation determines hot spots of DNA damage in the human P53 gene

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12 December 2020

Regulation of Mammalian Deoxyribonucleotide Biosynthesis by Nucleotides as Activators and Inhibitors

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12 December 2020

Suppression of intestinal neoplasia by DNA hypomethylation.

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12 December 2020

Expression of a cloned adenovirus gene is inhibited by in vitro methylation

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12 December 2020

5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes

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12 December 2020

S-adenosylmethionine decarboxylase as an enzyme target for therapy

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12 December 2020

S-Adenosylmethionine and methylation

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12 December 2020

Implications of biochemical, cytokinetic, pharmacologic, and toxicologic relationships in the design of optimal therapeutic schedules

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12 December 2020

Kinetic studies on phosphorylation of 5-azacytidine with the purified uridine-cytidine kinase from calf thymus

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12 December 2020

HpaII methyltransferase is mutagenic in Escherichia coli

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12 December 2020

Different base/base mispairs are corrected with different efficiencies and specificities in monkey kidney cells.

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12 December 2020

Structural and conformational analogues of L-methionine as inhibitors of the enzymatic synthesis of S-adenosyl-l-methionine. I. Saturated and unsaturated aliphatic amino acids

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12 December 2020

Drug-induced DNA hypermethylation and drug resistance in human tumors.

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12 December 2020

The CpG dinucleotide and human genetic disease

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12 December 2020

Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas

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12 December 2020

Progressive de novo DNA methylation at the bcr-abl locus in the course of chronic myelogenous leukemia

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12 December 2020

Mechanism of action of eukaryotic DNA methyltransferase. Use of 5-azacytosine-containing DNA

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12 December 2020

CpG-rich islands and the function of DNA methylation

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12 December 2020

Identifiers

DOI

10.1023/A:1011946030404

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8 October 2017

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PubMed ID

9523301