Systemic Agonistic Anti-CD40 Treatment of Tumor-Bearing Mice Modulates Hepatic Myeloid-Suppressive Cells and Causes Immune-Mediated Liver Damage (Q35572171)

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scientific article published on 30 January 2015

Language	Label	Description	Also known as
English	Systemic Agonistic Anti-CD40 Treatment of Tumor-Bearing Mice Modulates Hepatic Myeloid-Suppressive Cells and Causes Immune-Mediated Liver Damage	scientific article published on 30 January 2015

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Systemic Agonistic Anti-CD40 Treatment of Tumor-Bearing Mice Modulates Hepatic Myeloid-Suppressive Cells and Causes Immune-Mediated Liver Damage (English)

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

David E. Kleiner

6

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25637366%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

author name string

José Medina-Echeverz

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25637366%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Chi Ma

2

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PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25637366%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Austin G Duffy

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25637366%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Tobias Eggert

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25637366%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Nga Hawk

5

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25637366%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Firouzeh Korangy

7

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25637366%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Tim F Greten

8

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25637366%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

publication date

30 January 2015

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Europe PubMed Central

PubMed publication ID

8 August 2017

Cancer Immunology Research

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25637366%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

3

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25637366%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

5

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25637366%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

557-566

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25637366%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Tumor induced hepatic myeloid derived suppressor cells can cause moderate liver damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420683

12 July 2018

IFN-γ regulates survival and function of tumor-induced CD11b+ Gr-1high myeloid derived suppressor cells by modulating the anti-apoptotic molecule Bcl2a1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420683

12 July 2018

Locally delivered CD40 agonist antibody accumulates in secondary lymphoid organs and eradicates experimental disseminated bladder cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420683

12 July 2018

Combined anti-CD40 and anti-IL-23 monoclonal antibody therapy effectively suppresses tumor growth and metastases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420683

12 July 2018

CD40L gene therapy tilts the myeloid cell profile and promotes infiltration of activated T lymphocytes

1 reference

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12 July 2018

Mitigating the toxic effects of anticancer immunotherapy

1 reference

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12 July 2018

Antitumor effects of anti-CD40/CpG immunotherapy combined with gemcitabine or 5-fluorouracil chemotherapy in the B16 melanoma model

1 reference

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12 July 2018

A phase I study of an agonist CD40 monoclonal antibody (CP-870,893) in combination with gemcitabine in patients with advanced pancreatic ductal adenocarcinoma

1 reference

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12 July 2018

Regulation of accumulation and function of myeloid derived suppressor cells in different murine models of hepatocellular carcinoma

1 reference

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The multifaceted role of the microenvironment in liver metastasis: biology and clinical implications

1 reference

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12 July 2018

Phase I study of the CD40 agonist antibody CP-870,893 combined with carboplatin and paclitaxel in patients with advanced solid tumors

1 reference

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12 July 2018

Agonist antibodies to TNFR molecules that costimulate T and NK cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420683

12 July 2018

Agonistic CD40 antibodies and cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420683

12 July 2018

STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420683

12 July 2018

Coordinated regulation of myeloid cells by tumours

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420683

12 July 2018

The blockade of immune checkpoints in cancer immunotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420683

12 July 2018

Characterization of the nature of granulocytic myeloid-derived suppressor cells in tumor-bearing mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420683

12 July 2018

mTOR kinase inhibitor AZD8055 enhances the immunotherapeutic activity of an agonist CD40 antibody in cancer treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420683

12 July 2018

Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420683

12 July 2018

Local activation of CD8 T cells and systemic tumor eradication without toxicity via slow release and local delivery of agonistic CD40 antibody

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420683

12 July 2018

Myeloid derived suppressor cells in human diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420683

12 July 2018

Reactive oxygen and mechanisms of inflammatory liver injury: Present concepts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420683

12 July 2018

Distinct populations of metastases-enabling myeloid cells expand in the liver of mice harboring invasive and preinvasive intra-abdominal tumor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420683

12 July 2018

Immune stimulatory receptor CD40 is required for T-cell suppression and T regulatory cell activation mediated by myeloid-derived suppressor cells in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420683

12 July 2018

Successful immunotherapy with IL-2/anti-CD40 induces the chemokine-mediated mitigation of an immunosuppressive tumor microenvironment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420683

12 July 2018

The liver is a site for tumor-induced myeloid-derived suppressor cell accumulation and immunosuppression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420683

12 July 2018

Interleukin-15 combined with an anti-CD40 antibody provides enhanced therapeutic efficacy for murine models of colon cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420683

12 July 2018

Mechanism regulating reactive oxygen species in tumor-induced myeloid-derived suppressor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420683

12 July 2018

Subsets of myeloid-derived suppressor cells in tumor-bearing mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420683

12 July 2018

A new population of myeloid-derived suppressor cells in hepatocellular carcinoma patients induces CD4(+)CD25(+)Foxp3(+) T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420683

12 July 2018

Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420683

12 July 2018

CD80 in immune suppression by mouse ovarian carcinoma-associated Gr-1+CD11b+ myeloid cells

1 reference

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12 July 2018

Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways

1 reference

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12 July 2018

Long-term expression of angiostatin suppresses metastatic liver cancer in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420683

12 July 2018

CD40 activation induces apoptosis in cultured human hepatocytes via induction of cell surface fas ligand expression and amplifies fas-mediated hepatocyte death during allograft rejection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420683

12 July 2018

CD40 AND CD154 IN CELL-MEDIATED IMMUNITY

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420683

12 July 2018

B7-H1 on myeloid-derived suppressor cells in immune suppression by a mouse model of ovarian cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420683

26 September 2018

Essential role for neutrophil recruitment to the liver in concanavalin A-induced hepatitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420683

26 September 2018

Synergy between chemotherapy and immunotherapy in the treatment of established murine solid tumors

1 reference

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26 September 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420683

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Immunology. Licence to kill

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420683

26 September 2018

CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420683

7 December 2018

Comparative analysis of monocytic and granulocytic myeloid-derived suppressor cell subsets in patients with gastrointestinal malignancies

1 reference

https://pubmed.ncbi.nlm.nih.gov/25637366

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conversion of tumor-specific CD4+ T-cell tolerance to T-cell priming through in vivo ligation of CD40

1 reference

https://pubmed.ncbi.nlm.nih.gov/25637366

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD40 antibody evokes a cytotoxic T-cell response that eradicates lymphoma and bypasses T-cell help

1 reference

https://pubmed.ncbi.nlm.nih.gov/25637366

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Superoxide produced by Kupffer cells is an essential effector in concanavalin A-induced hepatitis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/25637366

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recruitment of a myeloid cell subset (CD11b/Gr1mid) via CCL2/CCR2 promotes the development of colorectal cancer liver metastasis*

1 reference

https://pubmed.ncbi.nlm.nih.gov/25637366

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunosuppressive myeloid-derived suppressor cells can be converted into immunogenic APCs with the help of activated NKT cells: an alternative cell-based antitumor vaccine

1 reference

https://pubmed.ncbi.nlm.nih.gov/25637366

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD154-CD40 interactions drive hepatocyte apoptosis in murine fulminant hepatitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/25637366

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IFN-gamma arms human dendritic cells to perform multiple effector functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/25637366

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD154-CD40-independent up-regulation of B7-2 on splenic antigen-presenting cells and efficient T cell priming by staphylococcal enterotoxin A

1 reference

https://pubmed.ncbi.nlm.nih.gov/25637366

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/2326-6066.CIR-14-0182

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25637366%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25637366%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25637366%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

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