Design, synthesis, and biological evaluation of new cyclic melanotropin peptide analogues selective for the human melanocortin-4 receptor (Q35574655)

8 August 2017

title

Design, synthesis, and biological evaluation of new cyclic melanotropin peptide analogues selective for the human melanocortin-4 receptor (English)

1 reference

8 August 2017

Jinfa Ying

1

1 reference

8 August 2017

Xuyuan Gu

2

1 reference

8 August 2017

Minying Cai

3

1 reference

8 August 2017

Matthew Dedek

4

1 reference

8 August 2017

Josef Vagner

5

1 reference

8 August 2017

Dev B Trivedi

6

1 reference

8 August 2017

Victor J Hruby

7

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8 August 2017

language of work or name

English

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publication date

1 November 2006

1 reference

Journal of Medicinal Chemistry

8 August 2017

published in

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8 August 2017

volume

49

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8 August 2017

issue

23

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8 August 2017

page(s)

6888-6896

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New concepts in drug discovery: collateral efficacy and permissive antagonism

8 August 2017

cites work

1 reference

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Design of novel melanotropin agonists and antagonists with high potency and selectivity for human melanocortin receptors

12 July 2018

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Mechanisms of peptide and nonpeptide ligand binding to Class B G-protein-coupled receptors

12 July 2018

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Novel 3D pharmacophore of alpha-MSH/gamma-MSH hybrids leads to selective human MC1R and MC3R analogues

12 July 2018

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Allosteric modulation of G protein-coupled receptors: perspectives and recent developments

12 July 2018

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Solution structures of cyclic melanocortin agonists and antagonists by NMR.

12 July 2018

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Synthesis and structure-activity relationships of novel arylpiperazines as potent and selective agonists of the melanocortin subtype-4 receptor

12 July 2018

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Ac-nle-c[asp-his-dphe-arg-trp-lys]-nh2 induces penile erection via brain and spinal melanocortin receptors

12 July 2018

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The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans

12 July 2018

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Novel cyclic templates of alpha-MSH give highly selective and potent antagonists/agonists for human melanocortin-3/4 receptors

12 July 2018

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Preparation of 'side-chain-to-side-chain' cyclic peptides by Allyl and Alloc strategy: potential for library synthesis

12 July 2018

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Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides

12 July 2018

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Targeted disruption of the melanocortin-4 receptor results in obesity in mice

12 July 2018

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Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

12 July 2018

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Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7,Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin recep

12 July 2018

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4-Norleucine, 7-D-phenylalanine-alpha-melanocyte-stimulating hormone: a highly potent alpha-melanotropin with ultralong biological activity

12 July 2018

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Synthesis and pharmacological characterization in vitro of cyclic enkephalin analogs: effect of conformational constraints on opiate receptor selectivity

12 July 2018

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half-Cys4,half-Cys10-alpha-Melanocyte-stimulating hormone: a cyclic alpha-melanotropin exhibiting superagonist biological activity

12 July 2018

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A cyclic enkephalin analog with high in vitro opiate activity

12 July 2018

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The cloning of a family of genes that encode the melanocortin receptors

12 July 2018

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Highly active cyclic and bicyclic somatostatin analogues of reduced ring size

12 July 2018

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12 July 2018

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Design of a new peptidomimetic agonist for the melanocortin receptors based on the solution structure of the peptide ligand, Ac-Nle-cyclo[Asp-Pro-DPhe-Arg-Trp-Lys]-NH(2).

12 July 2018

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Solid-phase synthesis of amine-bridged cyclic enkephalin analogues via on-resin cyclization utilizing the Fukuyama-Mitsunobu reaction

26 September 2018

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Structure-activity studies of the melanocortin peptides: discovery of potent and selective affinity antagonists for the hMC3 and hMC4 receptors.

26 September 2018

1 reference

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Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor ago

26 September 2018

1 reference

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Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo.

26 September 2018

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Selective antagonist for the melanocortin 4 receptor (HS014) increases food intake in free-feeding rats

26 September 2018

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12 December 2020

Analogs of MTII, lactam derivatives of alpha-melanotropin, modified at the N-terminus, and their selectivity at human melanocortin receptors 3, 4, and 5

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12 December 2020

Peptoid-peptide hybrids as potent novel melanocortin receptor ligands

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12 December 2020

A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse

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12 December 2020

Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass

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12 December 2020

Conformational restrictions of biologically active peptides via amino acid side chain groups

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12 December 2020

Conformational and dynamic considerations in peptide structure-function studies

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12 December 2020

Conformational and dynamic considerations in the design of peptide hormone analogs

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12 December 2020

alpha-Melanotropin: the minimal active sequence in the frog skin bioassay

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12 December 2020

Alpha-melanotropin: the minimal active sequence in the lizard skin bioassay

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12 December 2020

Backbone cyclization: A new method for conferring conformational constraint on peptides

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12 December 2020

Identifiers

DOI

10.1021/JM060768F

1 reference

8 August 2017

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8 August 2017

1 reference