Genome protective effect of metformin as revealed by reduced level of constitutive DNA damage signaling (Q35590438)

9 August 2017

title

Genome protective effect of metformin as revealed by reduced level of constitutive DNA damage signaling (English)

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9 August 2017

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4

Frank Traganos

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9 August 2017

Zbyszek Darzynkiewicz

7

object named as

Zbigniew Darzynkiewicz

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9 August 2017

H Dorota Halicka

1

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9 August 2017

Hong Zhao

2

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9 August 2017

Jiangwei Li

3

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9 August 2017

Sufang Zhang

5

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9 August 2017

Marietta Lee

6

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9 August 2017

publication date

1 October 2011

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9 August 2017

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9 August 2017

volume

3

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9 August 2017

issue

10

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9 August 2017

page(s)

1028-1038

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AMP-activated protein kinase: nature's energy sensor

9 August 2017

cites work

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27 July 2018

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AMP-activated protein kinase and metabolic control

27 July 2018

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Mevalonate pathway inhibitors affect anticancer drug-induced cell death and DNA damage response of human sarcoma cells

27 July 2018

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Clinical Pharmacokinetics of Metformin

27 July 2018

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Role of oxidative stress and DNA damage in human carcinogenesis

27 July 2018

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Metformin promotes progesterone receptor expression via inhibition of mammalian target of rapamycin (mTOR) in endometrial cancer cells

27 July 2018

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Metformin for aging and cancer prevention

27 July 2018

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Revisiting the antagonistic pleiotropy theory of aging: TOR-driven program and quasi-program

27 July 2018

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Metformin: taking away the candy for cancer?

27 July 2018

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Metformin selectively attenuates mitochondrial H2O2 emission without affecting respiratory capacity in skeletal muscle of obese rats

27 July 2018

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27 July 2018

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Validation of anti-aging drugs by treating age-related diseases

27 July 2018

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Pseudo-DNA damage response in senescent cells

27 July 2018

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Rapamycin decelerates cellular senescence

27 July 2018

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27 July 2018

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Biscoclaurine alkaloid cepharanthine protects DNA in TK6 lymphoblastoid cells from constitutive oxidative damage.

27 July 2018

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DNA replication stress, genome instability and aging

27 July 2018

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Cytometry of ATM activation and histone H2AX phosphorylation to estimate extent of DNA damage induced by exogenous agents

27 July 2018

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AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling

27 July 2018

1 reference

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Discontinuous fragmentation of nuclear DNA during apoptosis revealed by discrete "sub-G1" peaks on DNA content histograms

27 July 2018

1 reference

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Constitutive histone H2AX phosphorylation and ATM activation are strongly amplified during mitogenic stimulation of lymphocytes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

Co-ordination of DNA single strand break repair

27 July 2018

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The ATM-dependent DNA damage signaling pathway

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

Constitutive histone H2AX phosphorylation on Ser-139 in cells untreated by genotoxic agents is cell-cycle phase specific and attenuated by scavenging reactive oxygen species.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

Laser scanning cytometry: principles and applications

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

2-deoxy-D-glucose reduces the level of constitutive activation of ATM and phosphorylation of histone H2AX.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

Cytometric assessment of DNA damage in relation to cell cycle phase and apoptosis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

Making ends meet in old age: DSB repair and aging

27 July 2018

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ATM activation in normal human tissues and testicular cancer

27 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

Artemis links ATM to double strand break rejoining

27 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

DNA damage responses to oxidative stress

27 July 2018

1 reference

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27 July 2018

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Interventions with antioxidants and nutrients in relation to oxidative DNA damage and repair

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

Non-homologous DNA end joining.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

Endogenous DNA double-strand breaks: Production, fidelity of repair, and induction of cancer

27 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

Oxy radicals, lipid peroxidation and DNA damage

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

Analysis of DNA damage in individual cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

Hydroxyl radicals and DNA base damage

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

Formation of DNA-protein cross-links in cultured mammalian cells upon treatment with iron ions

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

Macrophage-mediated induction of DNA strand breaks in target tumor cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

Phosphorylated H2Ax is not an unambiguous marker for DNA double-strand breaks.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

Genotoxicity screening via the γH2AX by flow assay.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

Effects of metformin on oxidative stress, adenine nucleotides balance, and glucose-induced insulin release impaired by chronic free fatty acids exposure in rat pancreatic islets.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

Increasing healthy lifespan by suppressing aging in our lifetime: preliminary proposal

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

Metformin activates AMP kinase through inhibition of AMP deaminase

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

New biomarkers probing depth of cell senescence assessed by laser scanning cytometry

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

Metformin reduces intracellular reactive oxygen species levels by upregulating expression of the antioxidant thioredoxin via the AMPK-FOXO3 pathway

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

Metformin induces suppression of NAD(P)H oxidase activity in podocytes.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

Metformin extends life span of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

Attenuation of constitutive ATM activation and H2AX phosphorylation in human leukemic TK6 cells by their exposure to static magnetic field.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

Ambivalent effects of diazoxide on mitochondrial ROS production at respiratory chain complexes I and III.

26 September 2018

1 reference

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Cancer and aging: more puzzles, more promises?

26 September 2018

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Protective effect of hyaluronate on oxidative DNA damage in WI-38 and A549 cells

26 September 2018

1 reference

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Cytometric assessment of DNA damage by exogenous and endogenous oxidants reports aging-related processes

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

Phosphorylation of histone H2AX on Ser 139 and activation of ATM during oxidative burst in phorbol ester-treated human leukocytes.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

Constitutive histone H2AX phosphorylation and ATM activation, the reporters of DNA damage by endogenous oxidants

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

Metformin decreases intracellular production of reactive oxygen species in aortic endothelial cells

26 September 2018

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26 September 2018

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Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions?

26 September 2018

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DNA damage induced by DNA topoisomerase I- and topoisomerase II-inhibitors detected by histone H2AX phosphorylation in relation to the cell cycle phase and apoptosis

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

Expression of phosphorylated histone H2AX as a surrogate of cell killing by drugs that create DNA double-strand breaks.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

Quantitative detection of (125)IdU-induced DNA double-strand breaks with gamma-H2AX antibody

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229966

26 September 2018

Oxidative Decay of DNA

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Generation of superoxide radicals as byproduct of cellular respiration.

26 September 2018

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Activated neutrophils induce prolonged DNA damage in neighboring cells

26 September 2018

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12 December 2020

Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays

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12 December 2020

Generation of reactive oxygen species by endothelial and smooth muscle cells: influence of hyperglycemia and metformin

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12 December 2020

Effect of coronary angiography on oxidative DNA damage observed in circulating lymphocytes

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12 December 2020

Effects of polycyclic aromatic hydrocarbons (PAHs) in environmental pollution on exogenous and oxidative DNA damage (EXPAH project): description of the population under study

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12 December 2020

Metformin activates an ataxia telangiectasia mutated (ATM)/Chk2-regulated DNA damage-like response

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Identifiers

DOI

10.18632/AGING.100397

0 references

PMC publication ID

3229966

1 reference

9 August 2017

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