AMP-activated protein kinase: nature's energy sensor (Q37902500)

25 August 2017

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title

AMP-activated protein kinase: nature's energy sensor (English)

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25 August 2017

4

Steven J Gamblin

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25 August 2017

David Carling

1

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author name string

Faith V Mayer

series ordinal

2

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25 August 2017

Matthew J Sanders

series ordinal

3

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25 August 2017

publication date

18 July 2011

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25 August 2017

published in

Nature Chemical Biology

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25 August 2017

volume

7

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25 August 2017

issue

8

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25 August 2017

page(s)

512-518

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The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?

25 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

AMP-activated protein kinase and its downstream transcriptional pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

AMPK: a metabolic gauge regulating whole-body energy homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

AMPK in Health and Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

AMPK inhibition in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

AMPK: an emerging drug target for diabetes and the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

A yeast gene that is essential for release from glucose repression encodes a protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

AF12198, a novel low molecular weight antagonist, selectively binds the human type I interleukin (IL)-1 receptor and blocks in vivo responses to IL-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Glucose repression in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Purification and characterization of the AMP-activated protein kinase. Copurification of acetyl-CoA carboxylase kinase and 3-hydroxy-3-methylglutaryl-CoA reductase kinase activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Mammalian AMP-activated protein kinase: functional, heterotrimeric complexes by co-expression of subunits in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Characterization and regulation of reductase kinase, a protein kinase that modulates the enzymic activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

The AMP-activated protein kinase--fuel gauge of the mammalian cell?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Thrombin activates AMP-activated protein kinase in endothelial cells via a pathway involving Ca2+/calmodulin-dependent protein kinase kinase beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Muscarinic receptor activation of AMP-activated protein kinase inhibits orexigenic neuropeptide mRNA expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Function of mammalian LKB1 and Ca2+/calmodulin-dependent protein kinase kinase alpha as Snf1-activating kinases in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Regulatory interactions between the Reg1-Glc7 protein phosphatase and the Snf1 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Evidence that AMP triggers phosphorylation as well as direct allosteric activation of rat liver AMP-activated protein kinase. A sensitive mechanism to protect the cell against ATP depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Ppm1E is an in cellulo AMP-activated protein kinase phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

The PP1-R6 protein phosphatase holoenzyme is involved in the glucose-induced dephosphorylation and inactivation of AMP-activated protein kinase, a key regulator of insulin secretion, in MIN6 beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Mutations in the gamma(2) subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Identification of a gene responsible for familial Wolff-Parkinson-White syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

AMP-activated protein kinase in the heart: role during health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Crystal structures of the adenylate sensor from fission yeast AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Structural basis for AMP binding to mammalian AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

AMPK structure and regulation from three angles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Structural insight into AMPK regulation: ADP comes into play

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Effect of exercise intensity on skeletal muscle AMPK signaling in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

The relationship between AMP-activated protein kinase activity and AMP concentration in the isolated perfused rat heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Structure of mammalian AMPK and its regulation by ADP

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Conserved alpha-helix acts as autoinhibitory sequence in AMP-activated protein kinase alpha subunits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Structural insight into the autoinhibition mechanism of AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Calmodulin-dependent protein kinase kinase-beta activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

AMPK beta subunit targets metabolic stress sensing to glycogen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

The glycogen-binding domain on the AMPK beta subunit allows the kinase to act as a glycogen sensor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

Inactivation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in vitro. An adenine nucleotide-dependent reaction catalyzed by a factor in human fibroblasts

21 January 2018

1 reference

12 December 2020

Allosteric activation of rat liver cytosolic 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase by nucleoside diphosphates

1 reference

12 December 2020

Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro

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12 December 2020

Regulation of hepatic acetyl coenzyme A carboxylase by phosphorylation and dephosphorylation

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12 December 2020

Mammalian AMP-activated protein kinase is homologous to yeast and plant protein kinases involved in the regulation of carbon metabolism.

1 reference

12 December 2020

Cytosolic phosphorylation potential

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12 December 2020

Modulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity with cAMP and wth protein fractions of rat liver cytosol

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12 December 2020

Oxidative phosphorylation and photophosphorylation

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12 December 2020

Regulation of liver hydroxymethylglutaryl-CoA reductase by a bicyclic phosphorylation system

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12 December 2020

The structure of a domain common to archaebacteria and the homocystinuria disease protein

1 reference

12 December 2020

Bateman domains and adenosine derivatives form a binding contract

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12 December 2020

Mammalian 5'-AMP-activated protein kinase non-catalytic subunits are homologs of proteins that interact with yeast Snf1 protein kinase

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12 December 2020

Regulation of free and bound magnesium in rat hepatocytes and isolated mitochondria

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12 December 2020

5'-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanisms

1 reference

12 December 2020

A suppressor of SNF1 mutations causes constitutive high-level invertase synthesis in yeast

1 reference

12 December 2020

Mutants of yeast defective in sucrose utilization.

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12 December 2020

Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase

1 reference

12 December 2020

Regulation of rat liver acetyl-CoA carboxylase. Regulation of phosphorylation and inactivation of acetyl-CoA carboxylase by the adenylate energy charge

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12 December 2020

AMP deamination and purine exchange in human skeletal muscle during and after intense exercise

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12 December 2020

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

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12 December 2020

Mammalian AMP-activated protein kinase subfamily

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12 December 2020

A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis

1 reference

12 December 2020

An antibody VH domain with a lox-Cre site integrated into its coding region: bacterial recombination within a single polypeptide chain

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.610

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NCHEMBIO.610

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25 August 2017

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