Interaction between leucine and phosphodiesterase 5 inhibition in modulating insulin sensitivity and lipid metabolism (Q35592315)

9 August 2017

Interaction between leucine and phosphodiesterase 5 inhibition in modulating insulin sensitivity and lipid metabolism (English)

1 reference

9 August 2017

Michael B Zemel

9

0 references

author name string

Lizhi Fu

1

1 reference

9 August 2017

Fenfen Li

2

1 reference

9 August 2017

Antje Bruckbauer

3

1 reference

9 August 2017

Qiang Cao

4

1 reference

9 August 2017

Xin Cui

5

1 reference

9 August 2017

Rui Wu

6

1 reference

9 August 2017

Hang Shi

7

1 reference

9 August 2017

Bingzhong Xue

8

1 reference

9 August 2017

6 May 2015

1 reference

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy

9 August 2017

1 reference

9 August 2017

8

1 reference

9 August 2017

227-239

1 reference

Creative Commons Attribution-NonCommercial 3.0 Unported

9 August 2017

start time

1 May 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Leucine Modulates Mitochondrial Biogenesis and SIRT1-AMPK Signaling in C2C12 Myotubes

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Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice

12 July 2018

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AMPK activation: a therapeutic target for type 2 diabetes?

12 July 2018

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Chronic inhibition of phosphodiesterase 5 with tadalafil attenuates mitochondrial dysfunction in type 2 diabetic hearts: potential role of NO/SIRT1/PGC-1α signaling.

12 July 2018

1 reference

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Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

12 July 2018

1 reference

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The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet

12 July 2018

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Synergistic effects of polyphenols and methylxanthines with Leucine on AMPK/Sirtuin-mediated metabolism in muscle cells and adipocytes

12 July 2018

1 reference

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Sirtuin 1 (SIRT1) activation mediates sildenafil induced delayed cardioprotection against ischemia-reperfusion injury in mice

12 July 2018

1 reference

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SIRT1 and other sirtuins in metabolism

12 July 2018

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Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging

12 July 2018

1 reference

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Plant polyphenols in the treatment of age-associated diseases: revealing the pleiotropic effects of icariin by network analysis

12 July 2018

1 reference

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Sildenafil promotes eNOS activation and inhibits NADPH oxidase in the transgenic sickle cell mouse penis

12 July 2018

1 reference

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AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation

12 July 2018

1 reference

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SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice.

12 July 2018

1 reference

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Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3.

12 July 2018

1 reference

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A nitric oxide-dependent cross-talk between class I and III histone deacetylases accelerates skin repair

12 July 2018

1 reference

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Synergistic effects of metformin, resveratrol, and hydroxymethylbutyrate on insulin sensitivity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427070

Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice

12 July 2018

1 reference

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SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function

12 July 2018

1 reference

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Exendin-4 improves steatohepatitis by increasing Sirt1 expression in high-fat diet-induced obese C57BL/6J mice

12 July 2018

1 reference

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Endothelial NO/cGMP/VASP signaling attenuates Kupffer cell activation and hepatic insulin resistance induced by high-fat feeding

12 July 2018

1 reference

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Reduced vascular nitric oxide-cGMP signaling contributes to adipose tissue inflammation during high-fat feeding.

12 July 2018

1 reference

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cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action

12 July 2018

1 reference

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Tadalafil increases muscle capillary recruitment and forearm glucose uptake in women with type 2 diabetes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427070

Lack of SIRT1 (Mammalian Sirtuin 1) activity leads to liver steatosis in the SIRT1+/- mice: a role of lipid mobilization and inflammation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427070

Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases

12 July 2018

1 reference

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Reduced NO-cGMP signaling contributes to vascular inflammation and insulin resistance induced by high-fat feeding.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427070

Caloric restriction delays disease onset and mortality in rhesus monkeys

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427070

PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427070

Impact of 6-mo caloric restriction on myocardial ischemic tolerance: possible involvement of nitric oxide-dependent increase in nuclear Sirt1.

12 July 2018

1 reference

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Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistance.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427070

Sirt1 protects against high-fat diet-induced metabolic damage

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427070

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427070

SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427070

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427070

Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427070

SIRT1 mediates the effect of GLP-1 receptor agonist exenatide on ameliorating hepatic steatosis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427070

Tadalafil alters energy metabolism in C2C12 skeletal muscle cells

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427070

Chronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious mice.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427070

AMP-activated protein kinase is involved in endothelial NO synthase activation in response to shear stress.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427070

Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signaling.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427070

AMP-activated protein kinase phosphorylation of endothelial NO synthase

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25999751

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.2147/DMSO.S82338

1 reference

9 August 2017

1 reference

9 August 2017

1 reference