Novel FLT3 tyrosine kinase inhibitors (Q35594041)

9 August 2017

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title

Novel FLT3 tyrosine kinase inhibitors (English)

1 reference

9 August 2017

Mark Levis

1

1 reference

PubMed ID

14640939

9 August 2017

Donald Small

series ordinal

2

1 reference

PubMed ID

14640939

9 August 2017

language of work or name

English

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publication date

1 December 2003

1 reference

Expert Opinion on Investigational Drugs

9 August 2017

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9 August 2017

12

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9 August 2017

12

1 reference

9 August 2017

1951-1962

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Oncogenic kinase signalling

9 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Class III receptor tyrosine kinases: role in leukaemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

The roles of FLT3 in hematopoiesis and leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Inhibition of FLT3-mediated transformation by use of a tyrosine kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute myeloid leukemia blasts harboring FLT3 internal tandem duplication mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Bis(1H-2-indolyl)-1-methanones as inhibitors of the hematopoietic tyrosine kinase Flt3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Tricyclic quinoxalines as potent kinase inhibitors of PDGFR kinase, Flt3 and Kit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Receptor protein-tyrosine kinases and their signal transduction pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Theme and variations: juxtamembrane regulation of receptor protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

FLT3 signaling in hematopoietic cells involves CBL, SHC and an unknown P115 as prominent tyrosine-phosphorylated substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

SHC and SHIP phosphorylation and interaction in response to activation of the FLT3 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Human CD34+ hematopoietic stem cells capable of multilineage engrafting NOD/SCID mice express flt3: distinct flt3 and c-kit expression and response patterns on mouse and candidate human hematopoietic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Crystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: insights into kinase mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Activating mutations for the met tyrosine kinase receptor in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Two acute monocytic leukemia (AML-M5a) cell lines (MOLM-13 and MOLM-14) with interclonal phenotypic heterogeneity showing MLL-AF9 fusion resulting from an occult chromosome insertion, ins(11;9)(q23;p22p23).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Inhibition of the transforming activity of FLT3 internal tandem duplication mutants from AML patients by a tyrosine kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

A single amino acid exchange inverts susceptibility of related receptor tyrosine kinases for the ATP site inhibitor STI-571.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Sensitivity toward tyrosine kinase inhibitors varies between different activating mutations of the FLT3 receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Constitutive activation of c-kit by the juxtamembrane but not the catalytic domain mutations is inhibited selectively by tyrosine kinase inhibitors STI571 and AG1296.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-kit) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Rhebbing up mTOR: New Insights on TSC1 and TSC2, and the Pathogenesis of Tuberous Sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Inhibitors of protein kinases: CGP 41251, a protein kinase inhibitor with potential as an anticancer agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Identification of orally active, potent, and selective 4-piperazinylquinazolines as antagonists of the platelet-derived growth factor receptor tyrosine kinase family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Flt3 ligand can promote survival and macrophage development without proliferation in myeloid progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

Flt3 ligand supports the differentiation of early B cell progenitors in the presence of interleukin-11 and interleukin-7

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.12.1951

10.1517/13543784.12.12.1951

21 January 2018

Identifiers

DOI

1 reference

9 August 2017

1 reference

PubMed ID

14640939