Small molecule inhibition of the steroid receptor coactivators, SRC-3 and SRC-1. (Q35595711)

9 August 2017

Small molecule inhibition of the steroid receptor coactivators, SRC-3 and SRC-1. (English)

1 reference

9 August 2017

6

Bert W O'Malley

1 reference

9 August 2017

Ying Wang

1

1 reference

9 August 2017

David M Lonard

2

1 reference

9 August 2017

Yang Yu

3

1 reference

9 August 2017

Dar-Chone Chow

4

1 reference

9 August 2017

Timothy G Palzkill

5

1 reference

9 August 2017

3 November 2011

1 reference

9 August 2017

Molecular Endocrinology

1 reference

9 August 2017

25

1 reference

9 August 2017

12

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9 August 2017

2041-2053

1 reference

describes a project that uses

9 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3231837/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Steroid receptor coactivator-3 expression in lung cancer and its role in the regulation of cancer cell survival and proliferation

1 reference

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Global characterization of transcriptional impact of the SRC-3 coregulator

12 July 2018

1 reference

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Minireview: the SRC family of coactivators: an entrée to understanding a subset of polygenic diseases?

12 July 2018

1 reference

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Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery

12 July 2018

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The role and regulation of the nuclear receptor co-activator AIB1 in breast cancer.

12 July 2018

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Recent developments in anti-cancer agents targeting the Ras/Raf/ MEK/ERK pathway.

12 July 2018

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Disruption of the SRC-1 gene in mice suppresses breast cancer metastasis without affecting primary tumor formation

12 July 2018

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Unique roles of p160 coactivators for regulation of breast cancer cell proliferation and estrogen receptor-alpha transcriptional activity

12 July 2018

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Multi-modulation of nuclear receptor coactivators through posttranslational modifications

12 July 2018

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Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa

12 July 2018

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The AIB1 oncogene promotes breast cancer metastasis by activation of PEA3-mediated matrix metalloproteinase 2 (MMP2) and MMP9 expression

12 July 2018

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The nuclear receptor coactivator amplified in breast cancer-1 is required for Neu (ErbB2/HER2) activation, signaling, and mammary tumorigenesis in mice.

12 July 2018

1 reference

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Isothermal titration calorimetry.

12 July 2018

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Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

12 July 2018

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Epidermal growth factor receptor tyrosine phosphorylation and signaling controlled by a nuclear receptor coactivator, amplified in breast cancer 1.

12 July 2018

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SRC-3 coactivator functional lifetime is regulated by a phospho-dependent ubiquitin time clock

12 July 2018

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A cheminformatic toolkit for mining biomedical knowledge

12 July 2018

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Estrogen receptor signaling pathways in human non-small cell lung cancer

12 July 2018

1 reference

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Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins

12 July 2018

1 reference

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Signaling within a coactivator complex: methylation of SRC-3/AIB1 is a molecular switch for complex disassembly

12 July 2018

1 reference

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Screening of genetic and expression alterations of SRC1 gene in prostate cancer

12 July 2018

1 reference

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Molecular mechanisms of (-)-gossypol-induced apoptosis in human prostate cancer cells.

12 July 2018

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(-)-gossypol inhibits growth and promotes apoptosis of human head and neck squamous cell carcinoma in vivo

12 July 2018

1 reference

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Coactivators and corepressors of NF-kappaB in IkappaB alpha gene promoter

12 July 2018

1 reference

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Associations and interactions between Ets-1 and Ets-2 and coregulatory proteins, SRC-1, AIB1, and NCoR in breast cancer

12 July 2018

1 reference

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The nuclear receptor coactivator AIB1 mediates insulin-like growth factor I-induced phenotypic changes in human breast cancer cells

12 July 2018

1 reference

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Expression of SRC-1, AIB1, and PEA3 in HER2 mediated endocrine resistant breast cancer; a predictive role for SRC-1.

12 July 2018

1 reference

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Overexpression of the nuclear receptor coactivator AIB1 (SRC-3) during progression of pancreatic adenocarcinoma.

12 July 2018

1 reference

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Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways

12 July 2018

1 reference

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Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer

12 July 2018

1 reference

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ACTR/AIB1 functions as an E2F1 coactivator to promote breast cancer cell proliferation and antiestrogen resistance

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231837

Selective estrogen receptor modulators 4-hydroxytamoxifen and raloxifene impact the stability and function of SRC-1 and SRC-3 coactivator proteins

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231837

The sensitivity of lung cancer cell lines to the EGFR-selective tyrosine kinase inhibitor ZD1839 ('Iressa') is not related to the expression of EGFR or HER-2 or to K-ras gene status

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231837

Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins

12 July 2018

1 reference

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Specific ubiquitin-conjugating enzymes promote degradation of specific nuclear receptor coactivators

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231837

Molecular determinants for the tissue specificity of SERMs

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231837

Tyrphostin AG 1024 modulates radiosensitivity in human breast cancer cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231837

Expression of RAC 3, a steroid hormone receptor co-activator in prostate cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231837

Sequential recruitment of steroid receptor coactivator-1 (SRC-1) and p300 enhances progesterone receptor-dependent initiation and reinitiation of transcription from chromatin

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231837

Discovery of a novel Raf kinase inhibitor

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231837

Different expression of androgen receptor coactivators in human prostate

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231837

Blockade of the epidermal growth factor receptor tyrosine kinase suppresses tumorigenesis in MMTV/Neu + MMTV/TGF-alpha bigenic mice

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231837

The 26S proteasome is required for estrogen receptor-alpha and coactivator turnover and for efficient estrogen receptor-alpha transactivation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231837

AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231837

The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231837

Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231837

Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231837

AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231837

RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231837

The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231837

GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231837

TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231837

Sequence and characterization of a coactivator for the steroid hormone receptor superfamily

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231837

The coactivator SRC-1 is an essential coordinator of hepatic glucose production.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231837

Mice lacking the amplified in breast cancer 1/steroid receptor coactivator-3 are resistant to chemical carcinogen-induced mammary tumorigenesis

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231837

Correlation of AIB1 overexpression with advanced clinical stage of human colorectal carcinoma.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231837

AIB1/SRC-3 deficiency affects insulin-like growth factor I signaling pathway and suppresses v-Ha-ras-induced breast cancer initiation and progression in mice

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231837

Expression of estrogen receptor coregulators in normal and malignant human endometrium

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231837

Ribozyme targeting demonstrates that the nuclear receptor coactivator AIB1 is a rate-limiting factor for estrogen-dependent growth of human MCF-7 breast cancer cells.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231837

Determination of the affinity of drugs toward serum albumin by measurement of the quenching of the intrinsic tryptophan fluorescence of the protein.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231837

Antiproliferative activity of gossypol and gossypolone on human breast cancer cells.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231837

In breast cancer, amplification of the steroid receptor coactivator gene AIB1 is correlated with estrogen and progesterone receptor positivity

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231837

High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231837

Prognostic significance ofc-myc andAIB1 amplification in hepatocellular carcinoma

15 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3231837

Gossypol, a phytochemical with BH3-mimetic property, sensitizes cultured thoracic cancer cells to Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand

15 November 2018

1 reference

12 December 2020

Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells

1 reference

12 December 2020

Differential cytotoxic effect of gossypol on human melanoma, colon carcinoma, and other tissue culture cell lines

1 reference

12 December 2020

Comparison of the effects of gossypol, estradiol-17 beta and testosterone compensation on male rat reproductive organs

1 reference

12 December 2020

Gossypol injected in the rat epididymal fat pad inhibits epididymal sperm motility

1 reference

12 December 2020

Identifiers

DOI

10.1210/ME.2011-1222

1 reference

9 August 2017

1 reference

9 August 2017

1 reference