11beta-Hydroxysteroid dehydrogenase Type 1 in obesity and Type 2 diabetes (Q35599114)

9 August 2017

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title

11beta-Hydroxysteroid dehydrogenase Type 1 in obesity and Type 2 diabetes (English)

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9 August 2017

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Stulnig TM

1

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PubMed ID

14652720

9 August 2017

Waldhäusl W

series ordinal

2

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PubMed ID

14652720

9 August 2017

language of work or name

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3 December 2003

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9 August 2017

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9 August 2017

47

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9 August 2017

1

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9 August 2017

1-11

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https://scigraph.springernature.com/pub.10.1007/s00125-003-1284-4

9 August 2017

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cites work

Prereceptor regulation of glucocorticoid action by 11beta-hydroxysteroid dehydrogenase: a novel determinant of cell proliferation

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12 December 2020

Insulin production rate, hepatic insulin retention and splanchnic carbohydrate metabolism after oral glucose ingestion in hyperinsulinaemic Type 2 (non-insulin-dependent) diabetes mellitus

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12 December 2020

Role of glucocorticoids and fatty acids in the impairment of lipid metabolism observed in the metabolic syndrome

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12 December 2020

Intracellular regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase (11beta-HSD)-1 plays a key role in regulation of the hypothalamic-pituitary-adrenal axis: analysis of 11beta-HSD-1-deficient mice

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12 December 2020

Pancreatic beta cells are important targets for the diabetogenic effects of glucocorticoids.

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12 December 2020

Mineralocorticoid excess and inhibition of 11 beta-hydroxysteroid dehydrogenase in patients with ectopic ACTH syndrome

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12 December 2020

Increments in insulin sensitivity during intensive treatment are closely correlated with decrements in glucocorticoid receptor mRNA in skeletal muscle from patients with Type II diabetes

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12 December 2020

Abnormal cortisol metabolism and tissue sensitivity to cortisol in patients with glucose intolerance.

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12 December 2020

The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes

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12 December 2020

11 beta-Hydroxysteroid dehydrogenase

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12 December 2020

Function, gene organization and protein structures of 11beta-hydroxysteroid dehydrogenase isoforms

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12 December 2020

Modulation of 11beta-hydroxysteroid dehydrogenase isozymes by growth hormone and insulin-like growth factor: in vivo and in vitro studies

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12 December 2020

Metabolic effects of the nocturnal rise in cortisol on carbohydrate metabolism in normal humans

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12 December 2020

11Beta-hydroxysteroid dehydrogenase type 1 in differentiating omental human preadipocytes: from de-activation to generation of cortisol

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12 December 2020

Does central obesity reflect "Cushing's disease of the omentum"?

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12 December 2020

Endocrine abnormalities of obesity.

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12 December 2020

11 beta-hydroxysteroid dehydrogenase type 1 expression in 2S FAZA hepatoma cells is hormonally regulated: a model system for the study of hepatic glucocorticoid metabolism

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12 December 2020

Increased urinary-free cortisol outputs in diabetic patients.

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12 December 2020

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

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12 December 2020

Type 1 11beta -hydroxysteroid dehydrogenase mediates glucocorticoid activation and insulin release in pancreatic islets

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12 December 2020

A role for insulin in the aetiology and course of hypertension?

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12 December 2020

Thiazolidinediones: metabolic actions in vitro

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12 December 2020

C/EBP regulates hepatic transcription of 11beta -hydroxysteroid dehydrogenase type 1. A novel mechanism for cross-talk between the C/EBP and glucocorticoid signaling pathways.

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12 December 2020

Carbenoxolone increases hepatic insulin sensitivity in man: a novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activation

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12 December 2020

Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11beta-hydroxysteroid dehydrogenase type 1 null mice

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12 December 2020

Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process?

1 reference

12 December 2020

Resistance to glucocorticoid feedback in obesity

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12 December 2020

Differential promoter usage by the rat 11 beta-hydroxysteroid dehydrogenase gene.

1 reference

12 December 2020

Pathophysiology of modulation of local glucocorticoid levels by 11beta-hydroxysteroid dehydrogenases

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12 December 2020

Effect of stress hormones on splanchnic substrate and insulin disposal after glucose ingestion in healthy humans

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12 December 2020

Lack of tissue glucocorticoid reactivation in 11beta -hydroxysteroid dehydrogenase type 1 knockout mice ameliorates age-related learning impairments

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12 December 2020

11Beta-hydroxysteroid dehydrogenase 1 in adipocytes: expression is differentiation-dependent and hormonally regulated

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12 December 2020

Increased glucocorticoid sensitivity in islet beta-cells: effects on glucose 6-phosphatase, glucose cycling and insulin release.

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12 December 2020

Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue

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12 December 2020

Glucocorticoids and insulin promote the differentiation of human adipocyte precursor cells into fat cells.

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12 December 2020

Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue

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12 December 2020

Homologous down regulation of the glucocorticoid receptor: the molecular machinery.

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12 December 2020

The relationship of blood pressure with glucose, insulin, heart rate, free fatty acids and plasma cortisol levels according to degree of obesity in middle-aged men.

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12 December 2020

Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease

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Cortisol effects on body mass, blood pressure, and cholesterol in the general population

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12 December 2020

Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression

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12 December 2020

Elevated plasma cortisol concentrations: a link between low birth weight and the insulin resistance syndrome?

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12 December 2020

Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice

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12 December 2020

11 beta-Hydroxysteroid dehydrogenase activity in hypothalamic obesity

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12 December 2020

Effects of glucocorticoid excess on the sensitivity of glucose transport and metabolism to insulin in rat skeletal muscle.

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12 December 2020

Differentiation of adipose stromal cells: the roles of glucocorticoids and 11beta-hydroxysteroid dehydrogenase

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12 December 2020

11 beta-hydroxysteroid dehydrogenase is an exclusive 11 beta- reductase in primary cultures of rat hepatocytes: effect of physicochemical and hormonal manipulations

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12 December 2020

CORTISOL METABOLISM IN OBESITY

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12 December 2020

Metabolic conversion as a pre-receptor control mechanism for lipophilic hormones

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12 December 2020

Arylsulfonamidothiazoles as a new class of potential antidiabetic drugs. Discovery of potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1.

1 reference

12 December 2020

Lack of relationship between 11beta-hydroxysteroid dehydrogenase setpoint and insulin sensitivity in the basal state and after 24h of insulin infusion in healthy subjects and type 2 diabetic patients

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12 December 2020

Glucocorticoids and muscle catabolism

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12 December 2020

Liver X receptors downregulate 11beta-hydroxysteroid dehydrogenase type 1 expression and activity.

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12 December 2020

11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress

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12 December 2020

Effects of glucocorticoids on carbohydrate metabolism

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12 December 2020

Peroxisome proliferator-activated receptor-gamma ligands inhibit adipocyte 11beta -hydroxysteroid dehydrogenase type 1 expression and activity

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12 December 2020

Understanding the role of glucocorticoids in obesity: tissue-specific alterations of corticosterone metabolism in obese Zucker rats

1 reference

12 December 2020

Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesis.

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12 December 2020

Insulin resistance in Cushing's syndrome

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12 December 2020

PPARalpha agonists reduce 11beta-hydroxysteroid dehydrogenase type 1 in the liver.

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12 December 2020

Expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue is not increased in human obesity

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12 December 2020

Steroid hormone receptors in human adipose tissues

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12 December 2020

Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids

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12 December 2020

Regulation of expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines

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12 December 2020

Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency

1 reference

12 December 2020

Cortisol metabolism in human obesity: impaired cortisone-->cortisol conversion in subjects with central adiposity

1 reference

12 December 2020

The perils of portliness: causes and consequences of visceral adiposity

1 reference

12 December 2020

PPAR-gamma: adipogenic regulator and thiazolidinedione receptor

1 reference

12 December 2020

A switch in dehydrogenase to reductase activity of 11 beta-hydroxysteroid dehydrogenase type 1 upon differentiation of human omental adipose stromal cells

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12 December 2020

Absence of Cushingoid phenotype in a patient with Cushing's disease due to defective cortisone to cortisol conversion

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12 December 2020

Diabetic neuropathy is associated with increased activity of the hypothalamic-pituitary-adrenal axis.

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12 December 2020

Increased glucocorticoid receptor expression in human skeletal muscle cells may contribute to the pathogenesis of the metabolic syndrome

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12 December 2020

A transgenic model of visceral obesity and the metabolic syndrome

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12 December 2020

The metabolic syndrome X and peripheral cortisol synthesis

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12 December 2020

CREB regulates hepatic gluconeogenesis through the coactivator PGC-1

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12 December 2020

Direct glucocorticoid inhibition of insulin secretion. An in vitro study of dexamethasone effects in mouse islets

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12 December 2020

Expression of the mRNA coding for 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue from obese patients: an in situ hybridization study

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12 December 2020

Interactions between oestradiol and glucocorticoid regulatory effects on liver-specific glucocorticoid-inducible genes: possible evidence for a role of hepatic 11beta-hydroxysteroid dehydrogenase type 1.

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12 December 2020

Apparent cortisone reductase deficiency: a functional defect in 11beta-hydroxysteroid dehydrogenase type 1

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12 December 2020

Insulin attenuates the stimulatory effects of tumor necrosis factor alpha on 11beta-hydroxysteroid dehydrogenase 1 in human adipose stromal cells

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12 December 2020

Associations between pituitary-adrenocortical function and abdominal obesity, hyperinsulinaemia and dyslipidaemia in normotensive males.

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12 December 2020

Effect of glycemic control on the overnight dexamethasone suppression test in patients with diabetes mellitus

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12 December 2020

Increased glucocorticoid activity in men with cardiovascular risk factors

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12 December 2020

Effects of the 11 beta-hydroxysteroid dehydrogenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes.

1 reference

12 December 2020

Regulation of 11 beta-hydroxysteroid dehydrogenase activity in human skin fibroblasts: enzymatic modulation of glucocorticoid action.

1 reference

12 December 2020

10.1007/S00125-003-1284-4

Identifiers

DOI

1 reference

9 August 2017

1 reference

PubMed ID

14652720