Ranolazine reduces Ca2+ overload and oxidative stress and improves mitochondrial integrity to protect against ischemia reperfusion injury in isolated hearts (Q35599994)

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scientific article published on 29 June 2011

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English	Ranolazine reduces Ca2+ overload and oxidative stress and improves mitochondrial integrity to protect against ischemia reperfusion injury in isolated hearts	scientific article published on 29 June 2011

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scholarly article

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7 February 2020

Ranolazine reduces Ca2+ overload and oxidative stress and improves mitochondrial integrity to protect against ischemia reperfusion injury in isolated hearts (English)

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7 February 2020

reperfusion injury

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based on heuristic

inferred from title

5

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7 February 2020

author name string

Mohammed Aldakkak

1

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7 February 2020

Amadou K S Camara

2

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7 February 2020

James S Heisner

3

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7 February 2020

Meiying Yang

4

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publication date

29 June 2011

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7 February 2020

Pharmacological Research

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7 February 2020

64

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4

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381-392

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7 February 2020

Mitochondrial free [Ca2+] increases during ATP/ADP antiport and ADP phosphorylation: exploration of mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

27 July 2018

Relationship between nonsustained ventricular tachycardia after non-ST-elevation acute coronary syndrome and sudden cardiac death: observations from the metabolic efficiency with ranolazine for less ischemia in non-ST-elevation acute coronary syndro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

27 July 2018

Clinical features and outcomes of women with unstable ischemic heart disease: observations from metabolic efficiency with ranolazine for less ischemia in non-ST-elevation acute coronary syndromes-thrombolysis in myocardial infarction 36 (MERLIN-TIMI

1 reference

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27 July 2018

Postconditioning: from experimental proof to clinical concept

1 reference

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27 July 2018

Mitochondrial matrix K+ flux independent of large-conductance Ca2+-activated K+ channel opening

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

27 July 2018

Potential therapeutic benefits of strategies directed to mitochondria.

1 reference

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27 July 2018

Comparison of cumulative planimetry versus manual dissection to assess experimental infarct size in isolated hearts

1 reference

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27 July 2018

Modulation of mitochondrial bioenergetics in the isolated Guinea pig beating heart by potassium and lidocaine cardioplegia: implications for cardioprotection.

1 reference

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27 July 2018

Mitochondrial reactive oxygen species production in excitable cells: modulators of mitochondrial and cell function.

1 reference

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27 July 2018

Enhanced Na+/H+ exchange during ischemia and reperfusion impairs mitochondrial bioenergetics and myocardial function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

27 July 2018

Myocardial reperfusion injury.

1 reference

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27 July 2018

Reverse electron flow-induced ROS production is attenuated by activation of mitochondrial Ca2+-sensitive K+ channels.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

27 July 2018

Modulation of electron transport protects cardiac mitochondria and decreases myocardial injury during ischemia and reperfusion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

27 July 2018

Ranolazine: new approach for the treatment of stable angina pectoris

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

27 July 2018

Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

27 July 2018

Mitochondrial metabolism of reactive oxygen species.

1 reference

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27 July 2018

Calcium, ATP, and ROS: a mitochondrial love-hate triangle

1 reference

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27 July 2018

Cariporide (HOE642), a Selective Na + -H + Exchange Inhibitor, Inhibits the Mitochondrial Death Pathway

1 reference

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27 July 2018

Production of reactive oxygen species by mitochondria: central role of complex III.

1 reference

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27 July 2018

Role of the cardiac Na+/H+ exchanger during ischemia and reperfusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

27 July 2018

Altered NADH and improved function by anesthetic and ischemic preconditioning in guinea pig intact hearts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

27 July 2018

Attenuation of postischemic reperfusion injury is related to prevention of [Ca2+]m overload in rat hearts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

27 July 2018

Increased work in cardiac trabeculae causes decreased mitochondrial NADH fluorescence followed by slow recovery.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

27 July 2018

Protective effects of ranolazine in guinea-pig hearts during low-flow ischaemia and their association with increases in active pyruvate dehydrogenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

27 July 2018

Investigation of factors affecting fluorometric quantitation of cytosolic [Ca2+] in perfused hearts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

27 July 2018

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

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27 July 2018

The effects of the novel anti-anginal compound RS 43285 on myocardial conduction in the anaesthetized dog

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

27 July 2018

Prevention of myocardial enzyme release by ranolazine in a primate model of ischaemia with reperfusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

27 July 2018

Ultrastructural quantitation of mitochondria and myofilaments in cardiac muscle from 10 different animal species including man

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

27 July 2018

Inward sodium current at resting potentials in single cardiac myocytes induced by the ischemic metabolite lysophosphatidylcholine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

27 July 2018

An isolated guinea pig heart preparation with in vivo like features

1 reference

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27 July 2018

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

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27 July 2018

The stabilizing effect of pyruvate on the function and metabolism of isolated perfused guinea pig hearts

1 reference

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27 July 2018

The mitochondrial permeability transition pore and the cardiac necrotic program.

1 reference

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26 September 2018

Phosphoproteome analysis of isoflurane-protected heart mitochondria: phosphorylation of adenine nucleotide translocator-1 on Tyr194 regulates mitochondrial function.

1 reference

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26 September 2018

NHE-1 inhibition-induced cardioprotection against ischaemia/reperfusion is associated with attenuation of the mitochondrial permeability transition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

26 September 2018

Inhibited mitochondrial respiration by amobarbital during cardiac ischaemia improves redox state and reduces matrix Ca2+ overload and ROS release

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

26 September 2018

Mitochondrial Ca2+-induced K+ influx increases respiration and enhances ROS production while maintaining membrane potential.

1 reference

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26 September 2018

Blocking late sodium current reduces hydrogen peroxide-induced arrhythmogenic activity and contractile dysfunction.

1 reference

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26 September 2018

Ischemia-reperfusion injury changes the dynamics of Ca2+-contraction coupling due to inotropic drugs in isolated hearts

1 reference

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26 September 2018

Warm ischemic preconditioning improves mitochondrial redox balance during and after mild hypothermic ischemia in guinea pig isolated hearts.

1 reference

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26 September 2018

Antagonism by ranolazine of the pro-arrhythmic effects of increasing late INa in guinea pig ventricular myocytes

1 reference

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26 September 2018

Myocardial density and composition: a basis for calculating intracellular metabolite concentrations

1 reference

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26 September 2018

Hypothermia augments reactive oxygen species detected in the guinea pig isolated perfused heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

26 September 2018

Hydrolysis of Ca2+-sensitive fluorescent probes by perfused rat heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

26 September 2018

How inotropic drugs alter dynamic and static indices of cyclic myoplasmic [Ca2+] to contractility relationships in intact hearts.

1 reference

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26 September 2018

Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: potential implications in intracellular fluorescence detection of superoxide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

26 September 2018

Na+/H+ exchange inhibition with cardioplegia reduces cytosolic [Ca2+] and myocardial damage after cold ischemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

26 September 2018

Sevoflurane exposure generates superoxide but leads to decreased superoxide during ischemia and reperfusion in isolated hearts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

26 September 2018

Anesthetic preconditioning attenuates mitochondrial Ca2+ overload during ischemia in Guinea pig intact hearts: reversal by 5-hydroxydecanoic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

26 September 2018

Ischemic preconditioning alters real-time measure of O2 radicals in intact hearts with ischemia and reperfusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

26 September 2018

Cytochrome c release from mitochondria proceeds by a two-step process

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

26 September 2018

Blocking Na(+)/H(+) exchange reduces [Na(+)](i) and [Ca(2+)](i) load after ischemia and improves function in intact hearts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

26 September 2018

Reduced cytosolic Ca(2+) loading and improved cardiac function after cardioplegic cold storage of guinea pig isolated hearts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

26 September 2018

Modulation of myocardial function and [Ca2+] sensitivity by moderate hypothermia in guinea pig isolated hearts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

26 September 2018

Generation of superoxide in cardiomyocytes during ischemia before reperfusion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

26 September 2018

Ionic mechanism of the effects of hydrogen peroxide in rat ventricular myocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

26 September 2018

Palmitoyl carnitine modifies sodium currents and induces transient inward current in ventricular myocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

26 September 2018

Cardioprotective effects of ranolazine (RS-43285) in the isolated perfused rabbit heart.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

26 September 2018

The antianginal agent ranolazine is a weak inhibitor of the respiratory complex I, but with greater potency in broken or uncoupled than in coupled mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233383

26 September 2018

ROS scavenging before 27 degrees C ischemia protects hearts and reduces mitochondrial ROS, Ca2+ overload, and changes in redox state

1 reference

https://pubmed.ncbi.nlm.nih.gov/21741479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts

1 reference

https://pubmed.ncbi.nlm.nih.gov/21741479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measurement of mitochondrial free Ca2+ concentration in living single rat cardiac myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21741479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myocardial necrosis induced by temporary occlusion of a coronary artery in the dog

1 reference

https://pubmed.ncbi.nlm.nih.gov/21741479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subcellular origin of the surface fluorescence of reduced nicotinamide nucleotides in the isolated perfused rat heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/21741479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of ranolazine, an antianginal agent with novel electrophysiological properties, on the incidence of arrhythmias in patients with non ST-segment elevation acute coronary syndrome: results from the Metabolic Efficiency With Ranolazine for Less

1 reference

https://pubmed.ncbi.nlm.nih.gov/21741479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ranolazine (RS-43285): a preliminary study of a new anti-anginal agent with selective effect on ischaemic myocardium

1 reference

https://pubmed.ncbi.nlm.nih.gov/21741479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Significant levels of oxidants are generated by isolated cardiomyocytes during ischemia prior to reperfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/21741479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrogen peroxide stimulates the Ca2+ release channel from skeletal muscle sarcoplasmic reticulum

1 reference

https://pubmed.ncbi.nlm.nih.gov/21741479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced reactive O2 species formation and preserved mitochondrial NADH and [Ca2+] levels during short-term 17 degrees C ischemia in intact hearts

1 reference

https://pubmed.ncbi.nlm.nih.gov/21741479

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.PHRS.2011.06.018

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7 February 2020

1 reference

Europe PubMed Central

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7 February 2020

1 reference

Europe PubMed Central

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7 February 2020

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