The PPAR-γ antagonist GW9662 elicits differentiation of M2c-like cells and upregulation of the MerTK/Gas6 axis: a key role for PPAR-γ in human macrophage polarization (Q35600280)

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scientific article published on 3 May 2015

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English	The PPAR-γ antagonist GW9662 elicits differentiation of M2c-like cells and upregulation of the MerTK/Gas6 axis: a key role for PPAR-γ in human macrophage polarization	scientific article published on 3 May 2015

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scholarly article

1 reference

Europe PubMed Central

9 August 2017

The PPAR-γ antagonist GW9662 elicits differentiation of M2c-like cells and upregulation of the MerTK/Gas6 axis: a key role for PPAR-γ in human macrophage polarization (English)

1 reference

Europe PubMed Central

9 August 2017

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25972766%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

author name string

Philip L Cohen

2

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11 June 2020

publication date

3 May 2015

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9 August 2017

Journal of Inflammation

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11 June 2020

12

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11 June 2020

36

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11 June 2020

copyright license

Creative Commons Attribution 4.0 International

3 May 2015

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April 2022 Public Data File from Crossref

copyright status

0 references

https://scigraph.springernature.com/pub.10.1186/s12950-015-0081-4

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Macrophage activation and polarization: nomenclature and experimental guidelines

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The expression and clinical significance of different forms of Mer receptor tyrosine kinase in systemic lupus erythematosus

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Increased expression of Mer tyrosine kinase in circulating dendritic cells and monocytes of lupus patients: correlations with plasma interferon activity and steroid therapy.

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Circulating levels of soluble MER in lupus reflect M2c activation of monocytes/macrophages, autoantibody specificities and disease activity

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IL-17 stimulates differentiation of human anti-inflammatory macrophages and phagocytosis of apoptotic neutrophils in response to IL-10 and glucocorticoids.

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Expansion of necrotic core and shedding of Mertk receptor in human carotid plaques: a role for oxidized polyunsaturated fatty acids?

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Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction

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Human atherosclerotic plaque alternative macrophages display low cholesterol handling but high phagocytosis because of distinct activities of the PPARγ and LXRα pathways.

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Autoimmune kidney disease and impaired engulfment of apoptotic cells in mice with macrophage peroxisome proliferator-activated receptor gamma or retinoid X receptor alpha deficiency

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STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells

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PPARγ ligands switched high fat diet-induced macrophage M2b polarization toward M2a thereby improving intestinal Candida elimination.

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Dynamic, M2-like remodeling phenotypes of CD11c+ adipose tissue macrophages during high-fat diet--induced obesity in mice

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PPARγ controls Dectin-1 expression required for host antifungal defense against Candida albicans.

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Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR.

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LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor

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Mer tyrosine kinase (MerTK) promotes macrophage survival following exposure to oxidative stress

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Coronary intraplaque hemorrhage evokes a novel atheroprotective macrophage phenotype

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The peroxisome proliferator-activated receptor gamma agonist rosiglitazone ameliorates murine lupus by induction of adiponectin

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12 July 2018

Exploring the full spectrum of macrophage activation

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12 July 2018

Human protein S inhibits the uptake of AcLDL and expression of SR-A through Mer receptor tyrosine kinase in human macrophages

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Macrophages, PPARs, and Cancer

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Mertk receptor mutation reduces efferocytosis efficiency and promotes apoptotic cell accumulation and plaque necrosis in atherosclerotic lesions of apoe-/- mice

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12 July 2018

Macrophage activation and polarization

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Long-term risk of cardiovascular events with rosiglitazone: a meta-analysis

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Human adipose tissue macrophages are of an anti-inflammatory phenotype but capable of excessive pro-inflammatory mediator production.

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Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes

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IL-13 induces expression of CD36 in human monocytes through PPARgamma activation.

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PPARgamma1 attenuates cytosol to membrane translocation of PKCalpha to desensitize monocytes/macrophages.

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10.1186/S12950-015-0081-4

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Europe PubMed Central

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11 June 2020

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24 November 2022

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11 June 2020

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11 June 2020

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