Adenosine receptor agonists: from basic medicinal chemistry to clinical development (Q35602688)

9 August 2017

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title

Adenosine receptor agonists: from basic medicinal chemistry to clinical development (English)

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9 August 2017

4

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9 August 2017

Luo Yan

1

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9 August 2017

Joachim C Burbiel

series ordinal

2

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9 August 2017

Astrid Maass

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3

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9 August 2017

language of work or name

English

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publication date

1 November 2003

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Expert Opinion on Emerging Drugs

9 August 2017

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9 August 2017

8

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9 August 2017

2

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9 August 2017

537-576

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Structure and function of adenosine receptors and their genes.

9 August 2017

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https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Pharmacology and therapeutic applications of A1 adenosine receptor ligands

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Pharmacology of adenosine A2A receptors and therapeutic applications

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Effect of gamma-butyrobetaine on fatty liver in juvenile visceral steatosis mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Identification by site-directed mutagenesis of residues involved in ligand recognition and activation of the human A3 adenosine receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Site-directed mutagenesis studies of human A(2A) adenosine receptors: involvement of glu(13) and his(278) in ligand binding and sodium modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Site-directed mutagenesis of the human adenosine A2A receptor. Critical involvement of Glu13 in agonist recognition

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Mutagenesis reveals structure-activity parallels between human A2A adenosine receptors and biogenic amine G protein-coupled receptors

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Site-directed mutagenesis identifies residues involved in ligand recognition in the human A2a adenosine receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Identification of the adenine binding site of the human A1 adenosine receptor

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Adenosine receptors and their ligands.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Adenosine receptor ligands-recent developments part I. Agonists

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728214.8.2.537

8-Cyclopentyl-1,3-dipropylxanthine (DPCPX)--a selective high affinity antagonist radioligand for A1 adenosine receptors

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Binding of [3H]MSX-2 (3-(3-hydroxypropyl)-7-methyl-8-(m-methoxystyryl)-1-propargylxanthine) to rat striatal membranes--a new, selective antagonist radioligand for A(2A) adenosine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

[(3)H]ZM241385--an antagonist radioligand for adenosine A(2A) receptors in rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

[3H]MRS 1754, a selective antagonist radioligand for A(2B) adenosine receptors

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728214.8.2.537

[(3)H]8-Ethyl-4-methyl-2-phenyl-(8R)-4,5,7,8-tetrahydro-1H-imidazo[2,1-i]-purin-5-one ([(3)H]PSB-11), a novel high-affinity antagonist radioligand for human A(3) adenosine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Human A(2A) adenosine receptors: high-affinity agonist binding to receptor-G protein complexes containing Gbeta(4).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Guanine nucleotide effects on 8-cyclopentyl-1,3-[3H]dipropylxanthine binding to membrane-bound and solubilized A1 adenosine receptors of rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

5'-substituted adenosine analogs as new high-affinity partial agonists for the adenosine A1 receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Adenosine receptors: new opportunities for future drugs.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Adenosine receptors and calcium: basis for proposing a third (A3) adenosine receptor

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Medicinal chemistry of adenosine A3 receptor ligands

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Adenosine therapy: a new approach to chronic heart failure

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Cardiac electrophysiology of adenosine. Basic and clinical concepts

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Diagnostic and therapeutic use of adenosine in patients with supraventricular tachyarrhythmias.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Binding thermodynamics at the human A(3) adenosine receptor

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728214.8.2.537

A functional screening of adenosine analogues at the adenosine A2B receptor: a search for potent agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Search for new purine- and ribose-modified adenosine analogues as selective agonists and antagonists at adenosine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

N-cycloalkyl derivatives of adenosine and 1-deazaadenosine as agonists and partial agonists of the A(1) adenosine receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

N-substituted adenosines as novel neuroprotective A(1) agonists with diminished hypotensive effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

The time course of cardioprotection induced by GR79236, a selective adenosine A1-receptor agonist, in myocardial ischaemia-reperfusion injury in the pig.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Adenosine A1 agonist at reperfusion trial (AART): results of a three-center, blinded, randomized, controlled experimental infarct study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

The effect of preconditioning (ischemic and pharmacological) on myocardial necrosis following coronary artery bypass graft surgery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Does a selective adenosine A(1) receptor agonist protect against exercise induced ischaemia in patients with coronary artery disease?

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Adenosine A1 receptor agonists inhibit trigeminovascular nociceptive transmission.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Effect of the adenosine A1 receptor agonist GR79236 on trigeminal nociception with blink reflex recordings in healthy human subjects

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Study of an adenosine A1 receptor agonist on trigeminally evoked dural blood vessel dilation in the anaesthetized rat

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

New 2,N6-disubstituted adenosines: potent and selective A1 adenosine receptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Adenosine A2B-receptor-mediated cyclic AMP accumulation in primary rat astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Molecular cloning and characterization of an adenosine receptor: the A3 adenosine receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

NEW BASE-ALTERED ADENOSINE ANALOGUES: SYNTHESIS AND AFFINITY AT ADENOSINE A1 and A2A RECEPTORS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

N6-cyclopentyl-2-(3-phenylaminocarbonyltriazene-1-yl)adenosine (TCPA), a very selective agonist with high affinity for the human adenosine A1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Ribose-modified nucleosides as ligands for adenosine receptors: synthesis, conformational analysis, and biological evaluation of 1'-C-methyl adenosine analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Comparative study of AMP579 and adenosine in inhibition of neutrophil-mediated vascular and myocardial injury during 24 h of reperfusion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Amp 579 reduces contracture and limits infarction in rabbit heart by activating adenosine A2 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

A randomized, double-blinded, placebo-controlled, dose-ranging study measuring the effect of an adenosine agonist on infarct size reduction in patients undergoing primary percutaneous transluminal coronary angioplasty: the ADMIRE (AmP579 Delivery fo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

A1 adenosine receptors and their ligands: overview and recent developments

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Intrinsic activity at adenosine A1 receptors: partial and inverse agonism

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Selectivity of action of 8-alkylamino analogues of N6-cyclopentyladenosine in vivo: haemodynamic versus anti-lipolytic responses in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

5'-O-alkyl ethers of N,2-substituted adenosine derivatives: partial agonists for the adenosine A1 and A3 receptors

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Selective attenuation of isoproterenol-stimulated arrhythmic activity by a partial agonist of adenosine A1 receptor

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Interactions of valerian extracts and a fixed valerian-hop extract combination with adenosine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Lignans isolated from valerian: identification and characterization of a new olivil derivative with partial agonistic activity at A(1) adenosine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Modulation of atrioventricular nodal function by metabolic and allosteric regulators of endogenous adenosine in guinea pig heart

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Allosteric enhancer PD 81,723 acts by novel mechanism to potentiate cardiac actions of adenosine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Differential effects of the allosteric enhancer (2-amino-4,5-dimethyl-trienyl)[3-trifluoromethyl) phenyl]methanone (PD81,723) on agonist and antagonist binding and function at the human wild-type and a mutant (T277A) adenosine A1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Allosteric modulation of the adenosine A(1) receptor. Synthesis and biological evaluation of novel 2-amino-3-benzoylthiophenes as allosteric enhancers of agonist binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

2-Amino-3-benzoylthiophene Allosteric Enhancers of A1 Adenosine Agonist Binding: New 3, 4-, and 5-Modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Adenosine receptors and their modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Electrophysiological basis for the use of adenosine in the diagnosis and treatment of cardiac arrhythmias

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Adenosine and adenosine receptors in the cardiovascular system: biochemistry, physiology, and pharmacology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Medicinal chemistry of adenosine A2A receptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Structure-affinity relationships of the affinity of 2-pyrazolyl adenosine analogues for the adenosine A2A receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Pharmacological stress thallium scintigraphy with 2-cyclohexylmethylidenehydrazinoadenosine (WRC-0470). A novel, short-acting adenosine A2A receptor agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Cyclic AMP-dependent inhibition of human neutrophil oxidative activity by substituted 2-propynylcyclohexyl adenosine A(2A) receptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Pharmacological stress myocardial perfusion imaging with the potent and selective A(2A) adenosine receptor agonists ATL193 and ATL146e administered by either intravenous infusion or bolus injection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Influence of propranolol, enalaprilat, verapamil, and caffeine on adenosine A(2A)-receptor-mediated coronary vasodilation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Adenosine A2A analogue improves neurologic outcome after spinal cord trauma in the rabbit

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Adenosine A2A receptor activation decreases reperfusion injury associated with high-flow reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Agonist activity of 2- and 5'-substituted adenosine analogs and their N6-cycloalkyl derivatives at A1- and A2-adenosine receptors coupled to adenylate cyclase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Extracellular adenosine induces apoptosis of human arterial smooth muscle cells via A(2b)-purinoceptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Functional characterization of the adenosine receptor mediating inhibition of intestinal secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Adenosine modulation of neurotransmission in penile erection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

2-Substitution of N6-benzyladenosine-5'-uronamides enhances selectivity for A3 adenosine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Adenosine A3 receptors: novel ligands and paradoxical effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

N6,5'-Disubstituted adenosine derivatives as partial agonists for the human adenosine A3 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Structure-activity relationships of N6-benzyladenosine-5'-uronamides as A3-selective adenosine agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Comparative molecular field analysis of selective A3 adenosine receptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Synthesis and biological activity of a new series of N6-arylcarbamoyl, 2-(Ar)alkynyl-N6-arylcarbamoyl, and N6-carboxamido derivatives of adenosine-5'-N-ethyluronamide as A1 and A3 adenosine receptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Novel N6-(substituted-phenylcarbamoyl)adenosine-5'-uronamides as potent agonists for A3 adenosine receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

The synthesis of new adenosine A3 selective ligands containing bioisosteric isoxazoles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Purine nucleosides bearing 1-alkynyl chains as adenosine receptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

2-Substituted N-ethylcarboxamidoadenosine derivatives as high-affinity agonists at human A3 adenosine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Synthetic procedure for the preparation of novel potent and selective A3 adenosine receptor radioligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

3'-Aminoadenosine-5'-uronamides: discovery of the first highly selective agonist at the human adenosine A3 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Ring-Constrained (N)-methanocarba nucleosides as adenosine receptor agonists: independent 5'-uronamide and 2'-deoxy modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

N6-substituted D-4'-thioadenosine-5'-methyluronamides: potent and selective agonists at the human A3 adenosine receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

A physiological role of the adenosine A3 receptor: sustained cardioprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Activation and Desensitization of Rat A3-Adenosine Receptors by Selective Adenosine Derivatives and Xanthine-7-Ribosides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

2,5'-Disubstituted adenosine derivatives: evaluation of selectivity and efficacy for the adenosine A(1), A(2A), and A(3) receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Cardioprotective effects of adenosine A1 and A3 receptor activation during hypoxia in isolated rat cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Pharmacology and therapeutic applications of A3 receptor subtype

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Agonists to the A3 adenosine receptor induce G-CSF production via NF-kappaB activation: a new class of myeloprotective agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

A3 adenosine receptor as a target for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

The role and regulation of adenosine in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

A role for central A3-adenosine receptors. Mediation of behavioral depressant effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Agonist-induced desensitization of A2B adenosine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Adenosine deaminase and A1 adenosine receptors internalize together following agonist-induced receptor desensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Rapid agonist-induced desensitization and internalization of the A(2B) adenosine receptor is mediated by a serine residue close to the COOH terminus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Emerging molecular approaches to pain therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Indirect modulation of dopamine D2 receptors as potential pharmacotherapy for schizophrenia: I. Adenosine agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Adenosine receptor activation and nociception

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Adenosine A3 receptor stimulation and cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Effect of an adenosine antagonist and an adenosine agonist on status entry and severity in a model of limbic status epilepticus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Differential allosteric modulation by amiloride analogues of agonist and antagonist binding at A(1) and A(3) adenosine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Identification of Essential Residues Involved in the Allosteric Modulation of the Human A3Adenosine Receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Electrophysiological response of the right atrium to ibutilide during typical atrial flutter

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Electrophysiologic effects of a novel selective adenosine A1 agonist (CVT-510) on atrioventricular nodal conduction in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Termination of paroxysmal supraventricular tachycardia by tecadenoson (CVT-510), a novel A1-adenosine receptor agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

Agonist-Induced Internalization and Recycling of the Human A3 Adenosine Receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.8.2.537

21 January 2018

Identifiers

DOI

10.1517/14728214.8.2.537

1 reference

9 August 2017

1 reference