A mouse model suggests two mechanisms for thyroid alterations in infantile cystinosis: decreased thyroglobulin synthesis due to endoplasmic reticulum stress/unfolded protein response and impaired lysosomal processing. (Q35603385)

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scientific article published on 26 March 2015

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English	A mouse model suggests two mechanisms for thyroid alterations in infantile cystinosis: decreased thyroglobulin synthesis due to endoplasmic reticulum stress/unfolded protein response and impaired lysosomal processing.	scientific article published on 26 March 2015

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3 March 2020

A mouse model suggests two mechanisms for thyroid alterations in infantile cystinosis: decreased thyroglobulin synthesis due to endoplasmic reticulum stress/unfolded protein response and impaired lysosomal processing (English)

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3 March 2020

endoplasmic reticulum

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Corinne Antignac

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3 March 2020

Stephanie Cherqui

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3 March 2020

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H P Gaide Chevronnay

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V Janssens

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P Van Der Smissen

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X H Liao

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Y Abid

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N Nevo

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S Refetoff

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C E Pierreux

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P J Courtoy

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3 March 2020

2349-2364

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3 March 2020

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4430621/fullTextXML

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Brief reports: Lysosomal cross-correction by hematopoietic stem cell-derived macrophages via tunneling nanotubes

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12 July 2018

Nephropathic cystinosis: an international consensus document

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12 July 2018

Time course of pathogenic and adaptation mechanisms in cystinotic mouse kidneys

1 reference

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12 July 2018

Upregulation of the Rab27a-dependent trafficking and secretory mechanisms improves lysosomal transport, alleviates endoplasmic reticulum stress, and reduces lysosome overload in cystinosis

1 reference

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12 July 2018

Recent insights into the cell biology of thyroid angiofollicular units

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12 July 2018

Heptahelical protein PQLC2 is a lysosomal cationic amino acid exporter underlying the action of cysteamine in cystinosis therapy

1 reference

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12 July 2018

Hematopoietic stem cell gene therapy for the multisystemic lysosomal storage disorder cystinosis

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12 July 2018

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

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12 July 2018

Detection and analysis of proteins modified by O-linked N-acetylglucosamine

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12 July 2018

Measuring ER stress and the unfolded protein response using mammalian tissue culture system

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12 July 2018

Insights into novel cellular injury mechanisms by gene expression profiling in nephropathic cystinosis

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12 July 2018

Mice deficient in MCT8 reveal a mechanism regulating thyroid hormone secretion

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12 July 2018

Methods for monitoring endoplasmic reticulum stress and the unfolded protein response.

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12 July 2018

Regulated increase in folding capacity prevents unfolded protein stress in the ER.

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12 July 2018

Successful treatment of the murine model of cystinosis using bone marrow cell transplantation.

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12 July 2018

Opposite regulation of transforming growth factors-beta2 and -beta3 expression in the human endometrium

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12 July 2018

Defective protein folding and intracellular retention of thyroglobulin-R19K mutant as a cause of human congenital goiter

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Mediators of endoplasmic reticulum stress-induced apoptosis

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12 July 2018

Decreased intracellular ATP content and intact mitochondrial energy generating capacity in human cystinotic fibroblasts

1 reference

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12 July 2018

Mixed-disulfide folding intermediates between thyroglobulin and endoplasmic reticulum resident oxidoreductases ERp57 and protein disulfide isomerase.

1 reference

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12 July 2018

Altered status of glutathione and its metabolites in cystinotic cells

1 reference

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12 July 2018

Potential role of apoptosis in development of the cystinotic phenotype

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12 July 2018

XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.

1 reference

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12 July 2018

XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation

1 reference

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12 July 2018

Unfolded protein response is involved in the pathology of human congenital hypothyroid goiter and rat non-goitrous congenital hypothyroidism

1 reference

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12 July 2018

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

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12 July 2018

Development of the thyroid gland: lessons from congenitally hypothyroid mice and men.

1 reference

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12 July 2018

Thyroid functions of mouse cathepsins B, K, and L.

1 reference

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12 July 2018

Intralysosomal cystine accumulation in mice lacking cystinosin, the protein defective in cystinosis

1 reference

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12 July 2018

1 reference

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12 July 2018

The endocytic catalysts, Rab5a and Rab7, are tandem regulators of thyroid hormone production

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12 July 2018

Cystinosin, the protein defective in cystinosis, is a H(+)-driven lysosomal cystine transporter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4430621

12 July 2018

The targeting of cystinosin to the lysosomal membrane requires a tyrosine-based signal and a novel sorting motif

1 reference

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12 July 2018

Role of thyroglobulin endocytic pathways in the control of thyroid hormone release

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12 July 2018

Improved radioimmunoassay for measurement of mouse thyrotropin in serum: strain differences in thyrotropin concentration and thyrotroph sensitivity to thyroid hormone

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12 July 2018

Congenital hypothyroid goiter with deficient thyroglobulin. Identification of an endoplasmic reticulum storage disease with induction of molecular chaperones

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12 July 2018

The combined action of two thyroidal proteases releases T4 from the dominant hormone-forming site of thyroglobulin

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12 July 2018

An endoplasmic reticulum storage disease causing congenital goiter with hypothyroidism

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12 July 2018

Multimerization of thyroglobulin (TG) during extracellular storage: isolation of highly cross-linked TG from human thyroids

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12 July 2018

Calnexin and BiP act as sequential molecular chaperones during thyroglobulin folding in the endoplasmic reticulum

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12 July 2018

Fluorimetric assays for cathepsin B and cathepsin H with methylcoumarylamide substrates

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12 July 2018

Thyrotropin controls transcription of the thyroglobulin gene

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12 July 2018

Thyroxine (T4) release from thyroglobulin and its T4-containing peptide by thyroid thiol proteases

1 reference

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12 July 2018

Three-dimensional aspects of blood vessels in thyroids from normal, low iodine diet-treated, TSH-treated, and PTU-treated rats

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12 July 2018

Cysteine proteinases from human thyroids and their actions on thyroglobulin

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12 July 2018

Functional morphology of the thyroid

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12 July 2018

A cysteine-specific lysosomal transport system provides a major route for the delivery of thiol to human fibroblast lysosomes: possible role in supporting lysosomal proteolysis

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12 July 2018

Proteolytic processing of thyroglobulin by extracts of thyroid lysosomes

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12 July 2018

Isolation of insoluble secretory product from bovine thyroid: extracellular storage of thyroglobulin in covalently cross-linked form

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12 July 2018

Transient aggregation of nascent thyroglobulin in the endoplasmic reticulum: relationship to the molecular chaperone, BiP

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12 July 2018

Endocrine studies in cystinosis: compensated primary hypothyroidism

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12 July 2018

The role of reduced glutathione in thyroglobulin proteolysis iv vitro

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12 July 2018

Dedifferentiation and aberrations of the endolysosomal compartment characterize the early stage of nephropathic cystinosis

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25 September 2018

Reciprocal epithelial:endothelial paracrine interactions during thyroid development govern follicular organization and C-cells differentiation.

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25 September 2018

Kidney preservation by bone marrow cell transplantation in hereditary nephropathy.

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Epithelial: Endothelial cross-talk regulates exocrine differentiation in developing pancreas

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25 September 2018

Renal phenotype of the cystinosis mouse model is dependent upon genetic background

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25 September 2018

Growth and endocrine function in patients with Hurler syndrome after hematopoietic stem cell transplantation.

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25 September 2018

ER and oxidative stresses are common mediators of apoptosis in both neurodegenerative and non-neurodegenerative lysosomal storage disorders and are alleviated by chemical chaperones

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25 September 2018

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25 September 2018

High prevalence of subclinical hypothyroidism in patients with Anderson-Fabry disease.

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25 September 2018

Complete inhibition of goiter in mice requires combined gene therapy modification of angiopoietin, vascular endothelial growth factor, and fibroblast growth factor signaling

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25 September 2018

Evidence for processing of compact insoluble thyroglobulin globules in relation with follicular cell functional activity in the human and the mouse thyroid

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25 September 2018

Endoplasmic reticulum stress causes thyroglobulin retention in this organelle and triggers activation of nuclear factor-kappa B via tumor necrosis factor receptor-associated factor 2.

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25 September 2018

Thyroglobulin degradation by thyroidal proteases: action of purified cathepsin D.

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25 September 2018

Thyrotropin activates guanosine 5'-diphosphate/guanosine 5'-triphosphate exchange on the rate-limiting endocytic catalyst, Rab5a, in human thyrocytes in vivo and in vitro

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12 December 2020

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Cell population kinetics in dog and human adult thyroid

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12 December 2020

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Hypothyroidism in cystinosis. A clinical, endocrinologic and histologic study involving sixteen patients with cystinosis

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12 December 2020

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Transcriptional control of thyroglobulin gene expression by cyclic AMP

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12 December 2020

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Lysosomal digestion of thyroglobulin: role of cathepsin D and thiol proteases

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12 December 2020

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Cysteamine therapy delays the progression of nephropathic cystinosis in late adolescents and adults

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12 December 2020

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Caspase-4 may play a role in loss of proximal tubules and renal injury in nephropathic cystinosis

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12 December 2020

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Evidence for extracellularly acting cathepsins mediating thyroid hormone liberation in thyroid epithelial cells

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12 December 2020

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The thioredoxin boxes of thyroglobulin: possible implications for intermolecular disulfide bond formation in the follicle lumen

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12 December 2020

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Cystine: Compartmentalization within Lysosomes in Cystinotic Leukocytes

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12 December 2020

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Effects of early cysteamine therapy on thyroid function and growth in nephropathic cystinosis

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12 December 2020

based on heuristic

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Identifiers

10.1210/EN.2014-1672

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25811319%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

PMC publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25811319%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

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1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25811319%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

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