Akt/mTOR counteract the antitumor activities of cixutumumab, an anti-insulin-like growth factor I receptor monoclonal antibody (Q35612939)

9 August 2017

title

Akt/mTOR counteract the antitumor activities of cixutumumab, an anti-insulin-like growth factor I receptor monoclonal antibody (English)

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9 August 2017

1 reference

1 reference

4

Scott M Lippman

1 reference

9 August 2017

Dong Hoon Shin

1

1 reference

9 August 2017

Hye-Young Min

2

1 reference

9 August 2017

Adel K El-Naggar

3

1 reference

9 August 2017

Bonnie Glisson

5

1 reference

9 August 2017

Ho-Young Lee

6

1 reference

9 August 2017

publication date

6 October 2011

1 reference

Molecular Cancer Therapeutics

9 August 2017

published in

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9 August 2017

volume

10

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9 August 2017

issue

12

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9 August 2017

page(s)

2437-2448

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Cancer drug-resistance and a look at specific proteins: Rho GDP-dissociation inhibitor 2, Y-box binding protein 1, and HSP70/90 organizing protein in proteomics clinical application

9 August 2017

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Teasing out the best molecular marker in the AKT/mTOR pathway in head and neck squamous cell cancer patients

12 July 2018

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12 July 2018

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12 July 2018

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Mammalian target of rapamycin (mTOR) is involved in the survival of cells mediated by chemokine receptor 7 through PI3K/Akt in metastatic squamous cell carcinoma of the head and neck

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors

12 July 2018

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12 July 2018

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Insulin-like growth factor receptor as a therapeutic target in head and neck cancer

12 July 2018

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Implication of the insulin-like growth factor-IR pathway in the resistance of non-small cell lung cancer cells to treatment with gefitinib

12 July 2018

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Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of survivin expression counteract the antitumor action of erlotinib.

12 July 2018

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The role of the IGF system in cancer growth and metastasis: overview and recent insights

12 July 2018

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Head and neck cancer: past, present and future.

12 July 2018

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Down-regulation of insulin receptor by antibodies against the type I insulin-like growth factor receptor: implications for anti-insulin-like growth factor therapy in breast cancer.

12 July 2018

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Inhibition of invasion, angiogenesis, tumor growth, and metastasis by adenovirus-mediated transfer of antisense uPAR and MMP-9 in non-small cell lung cancer cells.

12 July 2018

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Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase

12 July 2018

1 reference

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Signalling by the type 1 insulin-like growth factor receptor: interplay with the epidermal growth factor receptor

12 July 2018

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The insulin like growth factor-1 receptor (IGF-1R) as a drug target: novel approaches to cancer therapy

12 July 2018

1 reference

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Insulin-like growth factors and neoplasia.

12 July 2018

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Survivin in apoptosis control and cell cycle regulation in cancer

12 July 2018

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Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors

12 July 2018

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M6P/IGF2R loss of heterozygosity in head and neck cancer associated with poor patient prognosis

12 July 2018

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The effects of insulin-like growth factors on tumorigenesis and neoplastic growth

12 July 2018

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A microplate assay for quantitation of anchorage-independent growth of transformed cells

12 July 2018

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Integrin signal masks growth-promotion activity of HB-EGF in monolayer cell cultures

12 July 2018

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25 September 2018

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Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab.

25 September 2018

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Plasma levels of insulin-like growth factor-I and lung cancer risk: a case-control analysis.

25 September 2018

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A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer.

25 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237768

Effects of type I and II interferons on cultured human breast cells: interaction with estrogen receptors and with tamoxifen

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237768

Test system for trifunctional antibodies in 3D MCTS culture

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21980128

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Concordant loss of imprinting of the human insulin-like growth factor II gene promoters in cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21980128

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/1535-7163.MCT-11-0235

1 reference

9 August 2017

1 reference

9 August 2017

1 reference