Oxidative stress as a therapeutic target in diabetes: revisiting the controversy (Q35621286)

9 August 2017

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title

Oxidative stress as a therapeutic target in diabetes: revisiting the controversy (English)

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9 August 2017

Wiernsperger NF

1

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9 August 2017

1 December 2003

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9 August 2017

Diabetes and Metabolism

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9 August 2017

29

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9 August 2017

579-585

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9 August 2017

6

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Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes

9 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Nitric oxide and peroxynitrite. The ugly, the uglier and the not so good: a personal view of recent controversies

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Free radicals, antioxidants, and nutrition

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Free radicals in the physiological control of cell function

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Balance between endogenous superoxide stress and antioxidant defenses

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Apoptosis in human aortic endothelial cells induced by hyperglycemic condition involves mitochondrial depolarization and is prevented by N-acetyl-L-cysteine

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Hyperglycemia potentiates collagen-induced platelet activation through mitochondrial superoxide overproduction

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Hyperglycemic switch from mitochondrial nitric oxide to superoxide production in endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Glycation, oxidation, and lipoxidation in the development of diabetic complications

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Role of oxidative stress in diabetic complications: a new perspective on an old paradigm

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Advanced glycation end products, oxidant stress and vascular lesions

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Inactivation of cellular enzymes by carbonyls and protein-bound glycation/glycoxidation products

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Glycation-induced inactivation and loss of antigenicity of catalase and superoxide dismutase

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

DNA cleavage induced by glycation of Cu,Zn-superoxide dismutase

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Insulin's stimulation of endothelial superoxide generation may reflect up-regulation of isoprenyl transferase activity that promotes rac translocation

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Hypercholesterolemia increases endothelial superoxide anion production

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Sleep and the endocrine system: new associations to old diseases

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Sleep apneas: an oxidative stress?

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Nitric oxide and lipid peroxidation

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Antioxidants, NFkappaB activation, and diabetogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes.

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Glycation-dependent, reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Preservation of human islet cell functional mass by anti-oxidative action of a novel SOD mimic compound

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients.

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Oxidative stress impairs insulin internalization in endothelial cells in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Prolonged oxidative stress impairs insulin-induced GLUT4 translocation in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Peroxynitrite-induced apoptosis in HL-60 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Glucose scavenging of nitric oxide

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Hyperglycaemia modifies the reaction of microvessels to insulin in rat skeletal muscle.

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2- imbalance in insulin-resistant rat aorta

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Cyclic strain-induced plasminogen activator inhibitor-1 (PAI-1) release from endothelial cells involves reactive oxygen species

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Are diabetic neuropathy, retinopathy and nephropathy caused by hyperglycemic exclusion of dehydroascorbate uptake by glucose transporters?

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Oxidative stress and diabetic vascular complications

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Diabetic vascular dysfunction: links to glucose-induced reductive stress and VEGF.

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Vascular targets of redox signalling in diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Glucose-induced oxidative stress in vascular contractile cells: comparison of aortic smooth muscle cells and retinal pericytes

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Modification of enzymatic antioxidants in retinal microvascular cells by glucose or advanced glycation end products.

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Diabetes mellitus enhances vascular matrix metalloproteinase activity: role of oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Plasma lipid peroxidation products and antioxidant enzyme activities in patients with type 2 diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Effects of vitamin A and insulin on the antioxidative state of diabetic rat heart: a comparison study with combination treatment

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Biomarkers of free radical damage applications in experimental animals and in humans

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Oxidative stress in mice is dependent on the free glucose content of the diet

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Meal-Generated Oxidative Stress in Type 2 Diabetic Patients

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Oxidative stress parameters in type I, type II and insulin-treated type 2 diabetes mellitus; insulin treatment efficiency

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Assessment of DNA base oxidation and glutathione level in patients with type 2 diabetes.

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Oxidative stress at onset and in early stages of type 1 diabetes in children and adolescents.

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Serum concentrations of vitamins A and E in impaired glucose tolerance.

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Plasma lipid peroxidation and hyperglycaemia: a connection through hyperinsulinaemia?

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Oxidative stress could precede endothelial dysfunction and insulin resistance in Indian Mauritians with impaired glucose metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Abnormal antioxidant status in impaired glucose tolerance and non-insulin-dependent diabetes mellitus.

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Uric acid concentration in subjects at risk of type 2 diabetes mellitus: relationship to components of the metabolic syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Relation between insulin resistance and plasma concentrations of lipid hydroperoxides, carotenoids, and tocopherols.

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Correlates of markers of oxidative status in the general population

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Increased risk of non-insulin dependent diabetes mellitus at low plasma vitamin E concentrations: a four year follow up study in men.

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Defects in microvascular haemodynamics during prediabetes: contributor or epiphenomenon?

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Endothelial dysfunction accompanies a pro-oxidant, pro-diabetic challenge in the insulin resistant, obese Zucker rat in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Effects of vitamin E on cardiovascular and microvascular outcomes in high-risk patients with diabetes: results of the HOPE study and MICRO-HOPE substudy

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Tocopherol-mediated peroxidation of lipoproteins: implications for vitamin E as a potential antiatherogenic supplement

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Advanced glycation end-products induce apoptosis of bovine retinal pericytes in culture: involvement of diacylglycerol/ceramide production and oxidative stress induction

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Antioxidant and prooxidant activities of alpha-lipoic acid and dihydrolipoic acid

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Non-antioxidant molecular functions of alpha-tocopherol (vitamin E).

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Lack of effect of oral vitamin C on blood pressure, oxidative stress and endothelial function in Type II diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Free radicals and antioxidants in the year 2000. A historical look to the future

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Oxygen radicals, a failure or a success of evolution?

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Insulin-stimulated hydrogen peroxide reversibly inhibits protein-tyrosine phosphatase 1b in vivo and enhances the early insulin action cascade

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Vascular free radical release. Ex vivo and in vivo evidence for a flow-dependent endothelial mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Therapeutic potential of anti-oxidants and diabetic retinopathy

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDL.

1 reference

https://api.crossref.org/works/10.1016%2FS1262-3636%2807%2970072-1

7 January 2021

10.1016/S1262-3636(07)70072-1

Identifiers

DOI

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9 August 2017

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PubMed ID

14707886