Mechanisms of ligand binding to the parathyroid hormone (PTH)/PTH-related protein receptor: selectivity of a modified PTH(1-15) radioligand for GalphaS-coupled receptor conformations (Q35622858)

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scientific article published on 8 December 2005

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English	Mechanisms of ligand binding to the parathyroid hormone (PTH)/PTH-related protein receptor: selectivity of a modified PTH(1-15) radioligand for GalphaS-coupled receptor conformations	scientific article published on 8 December 2005

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10 January 2020

Mechanisms of ligand binding to the parathyroid hormone (PTH)/PTH-related protein receptor: selectivity of a modified PTH(1-15) radioligand for GalphaS-coupled receptor conformations (English)

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Agnès Linglart

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Harald Jüppner

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Harald Jüppner

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Murat Bastepe

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Thomas J Gardella

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Thomas J Gardella

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Thomas Dean

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Matthew J Mahon

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John T Potts

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8 December 2005

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Molecular Endocrinology

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10 January 2020

931-943

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10 January 2020

The origins of diversity and specificity in g protein-coupled receptor signaling

1 reference

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12 July 2018

G alpha12/G alpha13 subunits of heterotrimeric G proteins mediate parathyroid hormone activation of phospholipase D in UMR-106 osteoblastic cells.

1 reference

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Parathyroid hormone and parathyroid hormone-related peptide, and their receptors

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Novel parathyroid hormone (PTH) antagonists that bind to the juxtamembrane portion of the PTH/PTH-related protein receptor

1 reference

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Amino-terminal parathyroid hormone fragment analogs containing alpha,alpha-di-alkyl amino acids at positions 1 and 3.

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G protein activation by G protein coupled receptors: ternary complex formation or catalyzed reaction?

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Conformational states of the corticotropin releasing factor 1 (CRF1) receptor: detection, and pharmacological evaluation by peptide ligands

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Ligand affinity for amino-terminal and juxtamembrane domains of the corticotropin releasing factor type I receptor: regulation by G-protein and nonpeptide antagonists

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Importance of the amino terminus in secretin family G protein-coupled receptors. Intrinsic photoaffinity labeling establishes initial docking constraints for the calcitonin receptor

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Implications of protein flexibility for drug discovery

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Interaction among four residues distributed through the secretin pharmacophore and a focused region of the secretin receptor amino terminus

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Receptor-mediated adenylyl cyclase activation through XLalpha(s), the extra-large variant of the stimulatory G protein alpha-subunit.

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Na(+)/H(+ ) exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling

1 reference

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Parathyroid hormone (PTH)-(1-14) and -(1-11) analogs conformationally constrained by alpha-aminoisobutyric acid mediate full agonist responses via the juxtamembrane region of the PTH-1 receptor

1 reference

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Analysis of parathyroid hormone (PTH)/secretin receptor chimeras differentiates the role of functional domains in the pth/ pth-related peptide (PTHrP) receptor on hormone binding and receptor activation

1 reference

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12 July 2018

Molecular properties of the PTH/PTHrP receptor

1 reference

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12 July 2018

Multiple sites of contact between the carboxyl-terminal binding domain of PTHrP-(1--36) analogs and the amino-terminal extracellular domain of the PTH/PTHrP receptor identified by photoaffinity cross-linking

1 reference

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12 July 2018

Quantitative cell membrane-based radioligand binding assays for parathyroid hormone receptors

1 reference

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12 July 2018

Studies of the N-terminal region of a parathyroid hormone-related peptide (1-36) analog: receptor subtype-selective agonists, antagonists, and photochemical cross-linking agents

1 reference

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12 July 2018

The (1-14) fragment of parathyroid hormone (PTH) activates intact and amino-terminally truncated PTH-1 receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242416

12 July 2018

Dual signaling and ligand selectivity of the human PTH/PTHrP receptor

1 reference

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Parathyroid hormone-receptor interactions identified directly by photocross-linking and molecular modeling studies

1 reference

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The complex regulation of receptor-coupled G-proteins

1 reference

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Mutations in the second cytoplasmic loop of the rat parathyroid hormone (PTH)/PTH-related protein receptor result in selective loss of PTH-stimulated phospholipase C activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242416

12 July 2018

The N-terminal region of the third intracellular loop of the parathyroid hormone (PTH)/PTH-related peptide receptor is critical for coupling to cAMP and inositol phosphate/Ca2+ signal transduction pathways

1 reference

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Identical complementary deoxyribonucleic acids encode a human renal and bone parathyroid hormone (PTH)/PTH-related peptide receptor

1 reference

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12 July 2018

The extracellular amino-terminal region of the parathyroid hormone (PTH)/PTH-related peptide receptor determines the binding affinity for carboxyl-terminal fragments of PTH-(1-34).

1 reference

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1 reference

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Determinants of [Arg2]PTH-(1-34) binding and signaling in the transmembrane region of the parathyroid hormone receptor

1 reference

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A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia

1 reference

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Multiple affinity forms of the calcitonin gene-related peptide receptor in rat cerebellum.

1 reference

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Spatial proximity between a photolabile residue in position 19 of salmon calcitonin and the amino terminus of the human calcitonin receptor

1 reference

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Spatial approximation between the amino terminus of a peptide agonist and the top of the sixth transmembrane segment of the secretin receptor.

1 reference

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Activation-independent parathyroid hormone receptor internalization is regulated by NHERF1 (EBP50).

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Selective ligand-induced stabilization of active and desensitized parathyroid hormone type 1 receptor conformations

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339275

12 December 2020

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Safety and tolerability of subcutaneous PTHrP(1-36) in healthy human volunteers: a dose escalation study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339275

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based on heuristic

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Short-term, high-dose parathyroid hormone-related protein as a skeletal anabolic agent for the treatment of postmenopausal osteoporosis

1 reference

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based on heuristic

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Coupling of the canine renal parathyroid hormone receptor to adenylate cyclase: modulation by guanyl nucleotides and N-ethylmaleimide

1 reference

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based on heuristic

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Solubilization of a guanine nucleotide-sensitive parathyroid hormone-receptor complex from canine renal cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Photoaffinity cross-linking identifies differences in the interactions of an agonist and an antagonist with the parathyroid hormone/parathyroid hormone-related protein receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339275

12 December 2020

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A surface-exposed region of G(salpha) in which substitutions decrease receptor-mediated activation and increase receptor affinity

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Identification of key components in the irreversibility of salmon calcitonin binding to calcitonin receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Minimization of parathyroid hormone. Novel amino-terminal parathyroid hormone fragments with enhanced potency in activating the type-1 parathyroid hormone receptor

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and characterization of a receptor for human parathyroid hormone and parathyroid hormone-related peptide

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a Mg(2+)- and guanyl nucleotide-dependent glucagon receptor cycle by use of permeabilized canine hepatocytes

1 reference

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Full activation of chimeric receptors by hybrids between parathyroid hormone and calcitonin. Evidence for a common pattern of ligand-receptor interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/16339275

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based on heuristic

inferred from PubMed ID database lookup

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10.1210/ME.2005-0349

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10 January 2020

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16339275%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16339275%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

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