Islet amyloid: a complication of islet dysfunction or an aetiological factor in Type 2 diabetes? (Q35628614)

9 August 2017

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title

Islet amyloid: a complication of islet dysfunction or an aetiological factor in Type 2 diabetes? (English)

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9 August 2017

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Clark A

1

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PubMed ID

14722650

9 August 2017

Nilsson MR

series ordinal

2

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9 August 2017

13 January 2004

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9 August 2017

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9 August 2017

47

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9 August 2017

157-169

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9 August 2017

2

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https://scigraph.springernature.com/pub.10.1007/s00125-003-1304-4

9 August 2017

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cites work

Islet amyloid polypeptide. A new beta cell secretory product related to islet amyloid deposits

1 reference

12 December 2020

The molecular basis of amyloidosis.

1 reference

12 December 2020

Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis

1 reference

12 December 2020

Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide.

1 reference

12 December 2020

Ultrastructural evidence that apoptosis is the mechanism by which human amylin evokes death in RINm5F pancreatic islet beta-cells.

1 reference

12 December 2020

Increased insulin secretion and glucose tolerance in mice lacking islet amyloid polypeptide (amylin).

1 reference

12 December 2020

Pancreatic beta-cell granule peptides form heteromolecular complexes which inhibit islet amyloid polypeptide fibril formation

1 reference

12 December 2020

Amylin modulates beta-cell glucose sensing via effects on stimulus-secretion coupling

1 reference

12 December 2020

Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus

1 reference

12 December 2020

Protofibrillar islet amyloid polypeptide permeabilizes synthetic vesicles by a pore-like mechanism that may be relevant to type II diabetes

1 reference

12 December 2020

Diabetics do not have increased Alzheimer-type pathology compared with age-matched control subjects. A retrospective postmortem immunocytochemical and histofluorescent study.

1 reference

12 December 2020

Amyloidosis of the islets of Langerhans. A restudy of islet hyalin in diabetic and non-diabetic individuals

1 reference

12 December 2020

Immunohistochemical morphometry of pancreatic endocrine cells in diabetic, normoglycaemic glucose-intolerant and normal cats

1 reference

12 December 2020

Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide

1 reference

12 December 2020

Watching amyloid fibrils grow by time-lapse atomic force microscopy

1 reference

12 December 2020

Immunohistology of islet amyloid polypeptide in diabetes mellitus: semi-quantitative studies in a post-mortem series

1 reference

12 December 2020

Islet capillary blood pressure increase mediated by hyperglycemia in NIDDM GK rats

1 reference

12 December 2020

Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis

1 reference

12 December 2020

The prohormone convertase enzyme 2 (PC2) is essential for processing pro-islet amyloid polypeptide at the NH2-terminal cleavage site

1 reference

12 December 2020

Rapid deposition of amyloid in human islets transplanted into nude mice.

1 reference

12 December 2020

Full-length rat amylin forms fibrils following substitution of single residues from human amylin

1 reference

12 December 2020

Identification of a novel human islet amyloid polypeptide beta-sheet domain and factors influencing fibrillogenesis

1 reference

12 December 2020

Molecular and functional characterization of amylin, a peptide associated with type 2 diabetes mellitus

1 reference

12 December 2020

Pore formation by the cytotoxic islet amyloid peptide amylin

1 reference

12 December 2020

Role of islet amyloid polypeptide secretion in insulin-resistant humans.

1 reference

12 December 2020

Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation

1 reference

12 December 2020

Chronic overproduction of islet amyloid polypeptide/amylin in transgenic mice: lysosomal localization of human islet amyloid polypeptide and lack of marked hyperglycaemia or hyperinsulinaemia

1 reference

12 December 2020

Islet amyloid develops diffusely throughout the pancreas before becoming severe and replacing endocrine cells.

1 reference

12 December 2020

Localisation of islet amyloid peptide in lipofuscin bodies and secretory granules of human B-cells and in islets of type-2 diabetic subjects

1 reference

12 December 2020

Insular Amyloidosis and Diabetes Mellitus in Macaca Nigra

1 reference

12 December 2020

Direct measurement of islet amyloid polypeptide fibrillogenesis by mass spectrometry

1 reference

12 December 2020

Amyloidogenicity of recombinant human pro-islet amyloid polypeptide (ProIAPP).

1 reference

12 December 2020

Islet amyloid polypeptide (amylin): no evidence of an abnormal precursor sequence in 25 type 2 (non-insulin-dependent) diabetic patients

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12 December 2020

Different sensitivity to the cytotoxic action of IAPP fibrils in two insulin-producing cell lines, HIT-T15 and RINm5F cells

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12 December 2020

Missense mutation of amylin gene (S20G) in Japanese NIDDM patients

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12 December 2020

The effect of apolipoprotein E deficiency on islet amyloid deposition in human islet amyloid polypeptide transgenic mice

1 reference

12 December 2020

THE RELATION OE DIABETES MELLITUS TO LESIONS OF THE PANCREAS. HYALINE DEGENERATION OF THE ISLANDS OE LANGERHANS.

1 reference

12 December 2020

Islet amyloid-associated diabetes in obese A(vy)/a mice expressing human islet amyloid polypeptide.

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12 December 2020

Effects of meal ingestion on plasma amylin concentration in NIDDM and nondiabetic humans.

1 reference

12 December 2020

Effects of sequential proline substitutions on amyloid formation by human amylin20-29.

1 reference

12 December 2020

Glycated proteins in diabetes

1 reference

12 December 2020

Treatment with growth hormone and dexamethasone in mice transgenic for human islet amyloid polypeptide causes islet amyloidosis and beta-cell dysfunction

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12 December 2020

A STUDY OF THE PATHOLOGICAL ANATOMY OF THE PANCREAS IN NINETY CASES OF DIABETES MELLITUS.

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12 December 2020

Basal and stimulated plasma levels of pancreatic amylin indicate its co-secretion with insulin in humans

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12 December 2020

Fibrillar islet amyloid polypeptide (amylin) is internalised by macrophages but resists proteolytic degradation.

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12 December 2020

Conformational transitions of islet amyloid polypeptide (IAPP) in amyloid formation in vitro

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12 December 2020

Effects of beta cell granule components on human islet amyloid polypeptide fibril formation

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12 December 2020

Oophorectomy promotes islet amyloid formation in human islet amyloid polypeptide transgenic mice

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12 December 2020

Amyloid deposition is delayed in mice with targeted deletion of the serum amyloid P component gene

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12 December 2020

Human islet amyloid polypeptide transgenic mice as a model of non-insulin-dependent diabetes mellitus (NIDDM).

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12 December 2020

The relation of islet amyloid to the clinical type of diabetes

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12 December 2020

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group

1 reference

12 December 2020

Processing of synthetic pro-islet amyloid polypeptide (proIAPP) 'amylin' by recombinant prohormone convertase enzymes, PC2 and PC3, in vitro.

1 reference

12 December 2020

Amyloid fibril formation is progressive and correlates with beta-cell secretion in transgenic mouse isolated islets

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12 December 2020

Pathogenesis, diagnosis and treatment of systemic amyloidosis

1 reference

12 December 2020

Low levels of asparagine deamidation can have a dramatic effect on aggregation of amyloidogenic peptides: implications for the study of amyloid formation

1 reference

12 December 2020

Identification of minimal peptide sequences in the (8-20) domain of human islet amyloid polypeptide involved in fibrillogenesis.

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12 December 2020

Extensive islet amyloid formation is induced by development of Type II diabetes mellitus and contributes to its progression: pathogenesis of diabetes in a mouse model

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12 December 2020

Pro islet amyloid polypeptide (ProIAPP) immunoreactivity in the islets of Langerhans

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12 December 2020

Lysosomes and pancreatic islet function. A quantitative estimation of crinophagy in the mouse pancreatic B-cell

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12 December 2020

Non-parallelism of islet amyloid polypeptide (amylin) and insulin gene expression in rats islets following dexamethasone treatment

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12 December 2020

Islet amyloid polypeptide in the islets of Langerhans: friend or foe?

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12 December 2020

Islet amyloid polypeptide in diabetic and non-diabetic Pima Indians

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12 December 2020

Intra- and extracellular amyloid fibrils are formed in cultured pancreatic islets of transgenic mice expressing human islet amyloid polypeptide

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12 December 2020

The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.

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12 December 2020

Design of peptide-based inhibitors of human islet amyloid polypeptide fibrillogenesis

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12 December 2020

Inhibitors can arrest the membrane activity of human islet amyloid polypeptide independently of amyloid formation

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12 December 2020

Islet Amyloid Polypeptide and Insulin Secretion From Isolated Perfused Pancreas of Fed, Fasted, Glucose-Treated, and Dexamethasone-Treated Rats

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12 December 2020

Beta-cell proliferation and apoptosis in the developing normal human pancreas and in hyperinsulinism of infancy

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12 December 2020

Islet amyloid formed from diabetes-associated peptide may be pathogenic in type-2 diabetes

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12 December 2020

Transgenic overexpression of human islet amyloid polypeptide inhibits insulin secretion and glucose elimination after gastric glucose gavage in mice.

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12 December 2020

Processing of pro-islet amyloid polypeptide (proIAPP) by the prohormone convertase PC2

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12 December 2020

Non-uniform distribution of islet amyloid in the pancreas of 'maturity-onset' diabetic patients

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12 December 2020

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

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12 December 2020

Contribution of advanced glycosylation to the amyloidogenicity of islet amyloid polypeptide

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12 December 2020

Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

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12 December 2020

Estrogen can prevent or reverse obesity and diabetes in mice expressing human islet amyloid polypeptide

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12 December 2020

Islet amyloid development in a mouse strain lacking endogenous islet amyloid polypeptide (IAPP) but expressing human IAPP

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12 December 2020

Amyloid fibrillogenesis: themes and variations

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12 December 2020

The S20G islet-associated polypeptide gene mutation in familial NIDDM

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12 December 2020

Evaluation of glycated insulin in diabetic animals using immunocytochemistry and radioimmunoassay.

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12 December 2020

Insulin secretory granule biogenesis and the proinsulin-processing endopeptidases

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12 December 2020

Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

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12 December 2020

Sequence divergence in a specific region of islet amyloid polypeptide (IAPP) explains differences in islet amyloid formation between species

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12 December 2020

Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy.

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12 December 2020

Preparation of synthetic human islet amyloid polypeptide (IAPP) in a stable conformation to enable study of conversion to amyloid-like fibrils

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12 December 2020

B cell granule peptides affect human islet amyloid polypeptide (IAPP) fibril formation in vitro

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12 December 2020

Apolipoprotein E is associated with islet amyloid and other amyloidoses: implications for Alzheimer's disease.

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12 December 2020

An islet amyloid peptide is derived from an 89-amino acid precursor by proteolytic processing

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12 December 2020

Release of incompletely processed proinsulin is the cause of the disproportionate proinsulinemia of NIDDM.

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12 December 2020

A feline model of experimentally induced islet amyloidosis

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12 December 2020

Multiple ramp domains are required for generation of amylin receptor phenotype from the calcitonin receptor gene product

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12 December 2020

The insulin and islet amyloid polypeptide genes contain similar cell-specific promoter elements that bind identical beta-cell nuclear complexes

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12 December 2020

Prolonged exposure of pancreatic beta cells to raised glucose concentrations results in increased cellular content of islet amyloid polypeptide precursors

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12 December 2020

S20G mutant amylin exhibits increased in vitro amyloidogenicity and increased intracellular cytotoxicity compared to wild-type amylin

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12 December 2020

The islet amyloid polypeptide (amylin) gene S20G mutation in Chinese subjects: evidence for associations with type 2 diabetes and cholesterol levels

1 reference

12 December 2020

A mnemonical or negative-co-operativity model for the activation of adenylate cyclase by a common G-protein-coupled calcitonin-gene-related neuropeptide (CGRP)/amylin receptor.

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12 December 2020

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12 December 2020

Plasma islet amyloid polypeptide (Amylin) levels and their responses to oral glucose in type 2 (non-insulin-dependent) diabetic patients.

1 reference

12 December 2020

S20G mutation of the amylin gene is associated with Type II diabetes in Japanese. Study Group of Comprehensive Analysis of Genetic Factors in Diabetes Mellitus

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12 December 2020

Diabetes mellitus in Macaca mulatta monkeys is characterised by islet amyloidosis and reduction in beta-cell population.

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12 December 2020

Glucose tolerance in Japanese subjects with S20G mutation of the amylin gene

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12 December 2020

A novel mutation in islet amyloid polypeptide (IAPP) gene promoter is associated with Type II diabetes mellitus

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12 December 2020

Macrophages and pancreatic islet amyloidosis

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12 December 2020

Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells

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12 December 2020

Sulfated glycosaminoglycans: a common constituent of all amyloids?

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12 December 2020

Dementia and its associations in type 2 diabetes mellitus: the Fremantle Diabetes Study.

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12 December 2020

Pancreatic expression and secretion of human islet amyloid polypeptide in a transgenic mouse.

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12 December 2020

Hyperproinsulinemia and amyloid in NIDDM. Clues to etiology of islet beta-cell dysfunction?

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12 December 2020

Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes

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12 December 2020

Increased dietary fat promotes islet amyloid formation and beta-cell secretory dysfunction in a transgenic mouse model of islet amyloid

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12 December 2020

Investigation and characterization of binding sites for islet amyloid polypeptide in rat membranes

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12 December 2020

Circulating levels of incretin hormones and amylin in the fasting state and after oral glucose in GH-deficient patients before and after GH replacement: a placebo-controlled study.

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12 December 2020

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

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12 December 2020

Non-linkage of the islet amyloid polypeptide gene with Type 2 (non-insulin-dependent) diabetes mellitus

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12 December 2020

Proteoglycans synthesized and secreted by pancreatic islet beta-cells bind amylin

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12 December 2020

[Amyloid of islets of Langerhans and its relation to diabetes mellitus (author's transl)]

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12 December 2020

Effects of free fatty acid on polymerization of islet amyloid polypeptide (IAPP) in vitro and on amyloid fibril formation in cultivated isolated islets of transgenic mice overexpressing human IAPP.

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12 December 2020

Human islet amyloid polypeptide accumulates at similar sites in islets of transgenic mice and humans

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12 December 2020

Effect of dexamethasone on insulin sensitivity, islet amyloid polypeptide and insulin secretion in humans

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12 December 2020

Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

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12 December 2020

Reduced amylin release is a characteristic of impaired glucose tolerance and type 2 diabetes in Japanese Americans.

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12 December 2020

Plasma islet amyloid polypeptide levels in obesity, impaired glucose tolerance and non-insulin-dependent diabetes mellitus

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12 December 2020

Islet amyloid and type 2 diabetes: from molecular misfolding to islet pathophysiology

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12 December 2020

Identification of a heparin binding domain in the N-terminal cleavage site of pro-islet amyloid polypeptide. Implications for islet amyloid formation

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12 December 2020

10.1007/S00125-003-1304-4

Identifiers

DOI

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9 August 2017

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PubMed ID

14722650