PPARalpha agonist-induced rodent tumors: modes of action and human relevance (Q35631058)

9 August 2017

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title

PPARalpha agonist-induced rodent tumors: modes of action and human relevance (English)

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9 August 2017

James E Klaunig

1

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9 August 2017

Michael A Babich

2

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9 August 2017

Karl P Baetcke

3

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9 August 2017

Jon C Cook

4

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9 August 2017

J Chris Corton

5

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9 August 2017

Raymond M David

6

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9 August 2017

John G DeLuca

7

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9 August 2017

David Y Lai

8

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9 August 2017

Richard H McKee

9

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9 August 2017

Jeffrey M Peters

10

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9 August 2017

Ruth A Roberts

11

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9 August 2017

Penelope A Fenner-Crisp

12

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9 August 2017

language of work or name

English

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publication date

1 January 2003

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Critical Reviews in Toxicology

9 August 2017

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9 August 2017

33

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9 August 2017

655-780

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9 August 2017

6

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The modulation of rat liver carcinogenesis by perfluorooctanoic acid, a peroxisome proliferator

9 August 2017

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Relationship between plasma lipids and palmitoyl-CoA hydrolase and synthetase activities with peroxisomal proliferation in rats treated with fibrates.

21 January 2018

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Neoplastic lesions of questionable significance to humans

21 January 2018

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Apoptosis: regulation and relevance to toxicology

21 January 2018

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Hepatic microsomal enzyme induction, beta-oxidation, and cell proliferation following administration of clofibrate, gemfibrozil, or bezafibrate in the CD rat.

21 January 2018

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Hepatocellular proliferation in response to a peroxisome proliferator does not require TNFalpha signaling

21 January 2018

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A biomarker approach to measuring human dietary exposure to certain phthalate diesters

21 January 2018

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Developmental and pharmacological regulation of apolipoprotein C-II gene expression. Comparison with apo C-I and apo C-III gene regulation

21 January 2018

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Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha)

21 January 2018

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Mechanistically-based human hazard assessment of peroxisome proliferator-induced hepatocarcinogenesis

21 January 2018

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Metabolism of DEHP: effects of prefeeding and dose variation, and comparative studies in rodents and the cynomolgus monkey (CMA studies).

21 January 2018

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Oncogenicity testing of 2-ethylhexanol in Fischer 344 rats and B6C3F1 mice.

21 January 2018

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Transcriptional control of triglyceride metabolism: fibrates and fatty acids change the expression of the LPL and apo C-III genes by activating the nuclear receptor PPAR.

21 January 2018

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Pleiotropic actions of peroxisome proliferator-activated receptors in lipid metabolism and atherosclerosis

21 January 2018

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Comparison of the acute and chronic mitogenic effects of the peroxisome proliferators methylclofenapate and clofibric acid in rat liver.

21 January 2018

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Suppression of liver cell apoptosis in vitro by the non-genotoxic hepatocarcinogen and peroxisome proliferator nafenopin

21 January 2018

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Molecular basis of non-responsiveness to peroxisome proliferators: the guinea-pig PPARalpha is functional and mediates peroxisome proliferator-induced hypolipidaemia

21 January 2018

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Effects of chronic treatment with the leukotriene D4-antagonist compound LY171883 on B6C3F1 mice

21 January 2018

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Hepatic peroxisome proliferation in rodents and its significance for humans

21 January 2018

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Regulation of rat liver apolipoprotein A-I, apolipoprotein A-II and acyl-coenzyme A oxidase gene expression by fibrates and dietary fatty acids

21 January 2018

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Comparison of the effects of Wyeth-14,643 in Crl:CD BR and Fisher-344 rats

21 January 2018

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Mechanisms of extrahepatic tumor induction by peroxisome proliferators in male CD rats

21 January 2018

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Ontogeny and species differences in the pancreatic expression and localization of the CCK(A) receptors

21 January 2018

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Influences of the PPAR alpha-L162V polymorphism on plasma HDL(2)-cholesterol response of abdominally obese men treated with gemfibrozil

21 January 2018

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Differential activation of adipogenesis by multiple PPAR isoforms.

21 January 2018

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Controlled death (apoptosis) of normal and putative preneoplastic cells in rat liver following withdrawal of tumor promoters

21 January 2018

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Toxicity of ammonium perfluorooctanoate in male cynomolgus monkeys after oral dosing for 6 months

21 January 2018

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Consideration of both genotoxic and nongenotoxic mechanisms in predicting carcinogenic potential

21 January 2018

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Cloning and characterization of RAP250, a novel nuclear receptor coactivator

21 January 2018

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Overexpression of DNA polymerase beta in cell results in a mutator phenotype and a decreased sensitivity to anticancer drugs

21 January 2018

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Do peroxisome proliferating compounds pose a hepatocarcinogenic hazard to humans?

21 January 2018

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Elevated 8-hydroxydeoxyguanosine in hepatic DNA of rats following exposure to peroxisome proliferators: relationship to carcinogenesis and nuclear localization

21 January 2018

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Initiator-specific promotion of hepatocarcinogenesis by WY-14,643 and clofibrate

21 January 2018

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21 January 2018

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The murine and human cholesterol 7alpha-hydroxylase gene promoters are differentially responsive to regulation by fatty acids mediated via peroxisome proliferator-activated receptor alpha

21 January 2018

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Transformation of mammalian cells by overexpressing H2O2-generating peroxisomal fatty acyl-CoA oxidase

21 January 2018

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Presence and inducibility of peroxisomes in a human glioblastoma cell line.

21 January 2018

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Oxidative DNA damage, antioxidants, and cancer

21 January 2018

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Relationship of oxidative damage to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl)phthalate and Wy-14,643.

21 January 2018

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Rodent Leydig cell tumorigenesis: a review of the physiology, pathology, mechanisms, and relevance to humans

21 January 2018

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Porcine gonadal and placental isozymes of aromatase cytochrome P450: sub-cellular distribution and support by NADPH-cytochrome P450 reductase

21 January 2018

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Peroxisome proliferators alter the expression of estrogen-metabolizing enzymes

21 January 2018

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Fenofibrate: metabolism and species differences for peroxisome proliferation in cultured hepatocytes

21 January 2018

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Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis

21 January 2018

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Comparative effects of clofibrate and methyl clofenapate on morphological transformation and intercellular communication of Syrian hamster embryo cells

21 January 2018

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Rotenone, an anticarcinogen, inhibits cellular proliferation but not peroxisome proliferation in mouse liver.

21 January 2018

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The peroxisome in retrospect

21 January 2018

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Modifications of liver bile acids pool during modulation of rat hepatocarcinogenesis by phenobarbital and nafenopin.

21 January 2018

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The peroxisome proliferator-activated receptors at the cross-road of diet and hormonal signalling.

21 January 2018

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The PPARalpha-leukotriene B4 pathway to inflammation control.

21 January 2018

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Investigations of the carcinogenicity of the LH-RH analog buserelin (HOE 766) in rats using the subcutaneous route of administration

21 January 2018

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A cancer risk assessment of di(2-ethylhexyl)phthalate: application of the new U.S. EPA Risk Assessment Guidelines

21 January 2018

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p300 functions as a coactivator for the peroxisome proliferator-activated receptor alpha

21 January 2018

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Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein

21 January 2018

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Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors

21 January 2018

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Effects of the peroxisome proliferator mono(2-ethylhexyl)phthalate in primary hepatocyte cultures derived from rat, guinea pig, rabbit and monkey. Relationship between interspecies differences in biotransformation and peroxisome proliferating potenc

21 January 2018

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Hepatocellular DNA synthesis in rats given peroxisome proliferating agents: comparison of WY-14,643 to clofibric acid, nafenopin and LY171883.

21 January 2018

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Peroxisome proliferator-activated receptor gamma induces pancreatic cancer cell apoptosis

21 January 2018

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The rodent nongenotoxic hepatocarcinogen and peroxisome proliferator nafenopin inhibits intercellular communication in rat but not guinea-pig hepatocytes, perturbing S-phase but not apoptosis

21 January 2018

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Peroxisome proliferation due to di(2-ethylhexyl) phthalate (DEHP): species differences and possible mechanisms

21 January 2018

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Biochemical, histological, and ultrastructural changes in rat and mouse liver following the administration of trichloroethylene: possible relevance to species differences in hepatocarcinogenicity.

21 January 2018

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Increased hydroxyl radical production in liver peroxisomal fractions from rats treated with peroxisome proliferators

21 January 2018

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Peroxisome proliferator-activated receptors: insight into multiple cellular functions

21 January 2018

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21 January 2018

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Steatohepatitis, spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty acyl-CoA oxidase. Implications for peroxisome proliferator-activated receptor alpha natural ligand metabolism.

21 January 2018

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Tissue-specific induction of 17 beta-hydroxysteroid dehydrogenase type IV by peroxisome proliferator chemicals is dependent on the peroxisome proliferator-activated receptor alpha.

21 January 2018

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Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta

21 January 2018

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Mechanism for species-specific induction of Leydig cell tumors in rats by lansoprazole

21 January 2018

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Helsinki Heart Study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease

21 January 2018

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Comparative chronic toxicity of three oral estrogens in rats.

21 January 2018

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The non-genotoxic hepatocarcinogen nafenopin suppresses rodent hepatocyte apoptosis induced by TGFbeta1, DNA damage and Fas.

21 January 2018

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Serum perfluorooctanoic acid and hepatic enzymes, lipoproteins, and cholesterol: A study of occupationally exposed men

21 January 2018

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Comparison of the effects of various peroxisome proliferators on peroxisomal enzyme activities, DNA synthesis, and apoptosis in rat and human hepatocyte cultures.

21 January 2018

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Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor

21 January 2018

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Multiple isoforms of porcine aromatase are encoded by three distinct genes

21 January 2018

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Peroxisomal enzyme induction uncoupled from enhanced DNA synthesis in putative preneoplastic liver foci of rats treated with a single dose of the peroxisome proliferator nafenopin.

21 January 2018

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Inherent increase of apoptosis in liver tumors: implications for carcinogenesis and tumor regression.

21 January 2018

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Peroxisome proliferation in primary cultures of rat hepatocytes

21 January 2018

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Trichloroethylene-induced mouse lung tumors: studies of the mode of action and comparisons between species.

21 January 2018

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Species differences in response to trichloroethylene. II. Biotransformation in rats and mice.

21 January 2018

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Animal toxicity studies with ammonium perfluorooctanoate.

21 January 2018

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Mortality and cancer morbidity in workers exposed to low levels of vinyl chloride monomer at a polyvinyl chloride processing plant.

21 January 2018

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Modulation of lipoprotein production in hep G2 cells by fenofibrate and clofibrate

21 January 2018

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Induction of peroxisomes by treatment with perfluorooctanoate does not increase rates of H2O2 production in intact liver

21 January 2018

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Catalase-dependent ethanol oxidation in perfused rat liver. Requirement for fatty-acid-stimulated H2O2 production by peroxisomes

21 January 2018

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Elimination and toxicity of perfluorooctanoic acid during subchronic administration in the Wistar rat.

21 January 2018

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Peroxisomal beta-oxidation: enzymology and molecular biology

21 January 2018

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Mouse hepatocyte response to peroxisome proliferators: dependency on hepatic nonparenchymal cells and peroxisome proliferator activated receptor alpha (PPARalpha).

21 January 2018

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Suppression of mouse hepatocyte apoptosis by peroxisome proliferators: role of PPARalpha and TNFalpha.

21 January 2018

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Role of hepatic non-parenchymal cells in the response of rat hepatocytes to the peroxisome proliferator nafenopin in vitro

21 January 2018

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Expression of the immediate-early genes, c-fos, c-jun, and c-myc: a comparison in rats of nongenotoxic hepatocarcinogens with noncarcinogenic liver mitogens

21 January 2018

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The mechanism underlying the hypolipemic effect of perfluorooctanoic acid (PFOA), perfluorooctane sulphonic acid (PFOSA) and clofibric acid

21 January 2018

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Mode of action of peroxisome proliferators as hypolipidemic drugs. Suppression of apolipoprotein C-III.

21 January 2018

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PPARs: transcriptional effectors of fatty acids and their derivatives

21 January 2018

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Effects of phthalic acid esters on the liver and thyroid

21 January 2018

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Functional antagonism between CCAAT/Enhancer binding protein-alpha and peroxisome proliferator-activated receptor-gamma on the leptin promoter

21 January 2018

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Deficiency of N-methylpurine-DNA-glycosylase expression in nonparenchymal cells, the target cell for vinyl chloride and vinyl fluoride

21 January 2018

1 reference

Plasma cholecystokinin response to oral fat in patients with Billroth I and Billroth II gastrectomy.

21 January 2018

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Modulation of diethylnitrosamine-initiated placental glutathione S-transferase positive preneoplastic and neoplastic lesions by clofibrate, a hepatic peroxisome proliferator.

21 January 2018

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Pancreatic carcinogenesis-enhancement by cholecystokinin in the hamster-nitrosamine model

21 January 2018

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Identification of peroxisome proliferator-responsive human genes by elevated expression of the peroxisome proliferator-activated receptor alpha in HepG2 cells

21 January 2018

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Hepatocarcinogenic potential of di(2-ethylhexyl)phthalate in rodents and its implications on human risk

21 January 2018

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The peroxisome proliferator-activated receptor alpha (PPARalpha) regulates bile acid biosynthesis.

21 January 2018

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Crosstalk between the thyroid hormone and peroxisome proliferator-activated receptors in regulating peroxisome proliferator-responsive genes.

21 January 2018

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Reversibility and persistence of di-2-ethylhexyl phthalate (DEHP)- and phenobarbital-induced hepatocellular changes in rodents

21 January 2018

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Effects of Di-2-ethylhexyl phthalate (DEHP) on gap-junctional intercellular communication (GJIC), DNA synthesis, and peroxisomal beta oxidation (PBOX) in rat, mouse, and hamster liver.

21 January 2018

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Inhibition of WY-14,643 induced hepatic lesion growth in mice by rotenone.

21 January 2018

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Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

21 January 2018

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The peroxisome proliferator-activated receptor:retinoid X receptor heterodimer is activated by fatty acids and fibrate hypolipidaemic drugs

21 January 2018

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Species differences in response to peroxisome proliferators correlate in vitro with induction of DNA synthesis rather than suppression of apoptosis

21 January 2018

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Suppression of hepatocyte apoptosis and induction of DNA synthesis by the rat and mouse hepatocarcinogen diethylhexylphlathate (DEHP) and the mouse hepatocarcinogen 1,4-dichlorobenzene (DCB).

21 January 2018

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The use of initiated cells as a test system for the detection of inhibitors of gap junctional intercellular communication

21 January 2018

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Human pancreatic acinar cells lack functional responses to cholecystokinin and gastrin

21 January 2018

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Gemfibrozil stimulates apolipoprotein A-I synthesis and secretion by stabilization of mRNA transcripts in human hepatoblastoma cell line (Hep G2).

21 January 2018

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Human apical sodium-dependent bile salt transporter gene (SLC10A2) is regulated by the peroxisome proliferator-activated receptor alpha

21 January 2018

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Comparative effects of phthalate monoesters on gap junctional intercellular communication and peroxisome proliferation in rodent and primate hepatocytes

21 January 2018

1 reference

Analysis of a form of oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis

21 January 2018

1 reference

Tumor induction in mouse liver: di-isononyl phthalate acts via peroxisome proliferation

21 January 2018

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21 January 2018

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PPAR alpha structure-function relationships derived from species-specific differences in responsiveness to hypolipidemic agents

21 January 2018

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Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting

21 January 2018

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Quantitative evaluation of alternative mechanisms of blood and testes disposition of di(2-ethylhexyl) phthalate and mono(2-ethylhexyl) phthalate in rats

21 January 2018

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Growth factor requirements for DNA synthesis by Leydig cells from the immature rat.

21 January 2018

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Inhibition of mouse hepatocyte intercellular communication by phthalate monoesters

21 January 2018

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Effects of trichloroethylene and its metabolites on rodent hepatocyte intercellular communication.

21 January 2018

1 reference

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma

21 January 2018

1 reference

The carcinogenicity of dietary di(2-ethylhexyl) phthalate (DEHP) in Fischer 344 rats and B6C3F1 mice.

21 January 2018

1 reference

Comparative chronic toxicities and carcinogenic potentials of 2-ethylhexyl-containing compounds in rats and mice.

21 January 2018

1 reference

Do bile acids exert a negative feedback control of cholecystokinin release?

21 January 2018

1 reference

Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay

21 January 2018

1 reference

Sex hormone-regulated renal transport of perfluorooctanoic acid

21 January 2018

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Mechanisms of hepatocarcinogenicity of peroxisome-proliferating drugs and chemicals

21 January 2018

1 reference

Peroxisome proliferation: current mechanisms relating to nongenotoxic carcinogenesis

21 January 2018

1 reference

Comparative studies on nafenopin-induced hepatic peroxisome proliferation in the rat, Syrian hamster, guinea pig, and marmoset

21 January 2018

1 reference

The in vitro hydrolysis of some phthalate diesters by hepatic and intestinal preparations from various species

21 January 2018

1 reference

Species differences in sequence and activity of the peroxisome proliferator response element (PPRE) within the acyl CoA oxidase gene promoter

21 January 2018

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Assessing possible hazards of reducing serum cholesterol

21 January 2018

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Differential gene regulation in human versus rodent hepatocytes by peroxisome proliferator-activated receptor (PPAR) alpha. PPAR alpha fails to induce peroxisome proliferation-associated genes in human cells independently of the level of receptor ex

21 January 2018

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Tumor necrosis factor alpha is not required for WY14,643-induced cell proliferation

21 January 2018

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Activation of immediate-early gene expression by peroxisome proliferators in vitro

21 January 2018

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Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators

21 January 2018

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Inhibition of intercellular communication of rat hepatocytes by nafenopin: involvement of protein kinase C.

21 January 2018

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A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders

21 January 2018

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Expression of the hydrogen peroxide-generating enzyme fatty acyl CoA oxidase activates NF-kappaB.

21 January 2018

1 reference

Chronic toxicity and carcinogenic evaluation of diisononyl phthalate in rats

21 January 2018

1 reference

The direct effect of hepatic peroxisome proliferators on rat Leydig cell function in vitro

21 January 2018

1 reference

Effect of the peroxisome proliferator, ammonium perfluorooctanoate (C8), on hepatic aromatase activity in adult male Crl:CD BR (CD) rats

21 January 2018

1 reference

Species differences in ciprofibrate induction of hepatic cytochrome p450 4A1 and peroxisome proliferation

21 January 2018

1 reference

Two-year inhalation toxicity study in rats with hydrochlorofluorocarbon 123.

21 January 2018

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trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals

21 January 2018

1 reference

Long-term carcinogenicity bioassays on trichloroethylene administered by inhalation to Sprague-Dawley rats and Swiss and B6C3F1 mice.

21 January 2018

1 reference

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

21 January 2018

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Functions and organization of peroxisomal beta-oxidation

21 January 2018

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Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activators

21 January 2018

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Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor

21 January 2018

1 reference

Identification of the proximate peroxisome proliferator(s) derived from di(2-ethylhexyl) phthalate

21 January 2018

1 reference

Inhibition of peroxisome proliferator signaling pathways by thyroid hormone receptor. Competitive binding to the response element.

21 January 2018

1 reference

Conformational changes in the A1 domain of von Willebrand factor modulating the interaction with platelet glycoprotein Ibalpha

21 January 2018

1 reference

Modulation of N-nitrosobis(2-hydroxypropyl)amine-induced carcinogenesis by clofibrate in hamsters

21 January 2018

1 reference

Effect of simultaneous administration of clofibrate with diethylnitrosamine on hepatic tumorigenesis in the rat.

21 January 2018

1 reference

Hepatic peroxisome (microbody) proliferation in rats fed plasticizers and related compounds

21 January 2018

1 reference

Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner.

21 January 2018

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Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators

21 January 2018

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Role of the peroxisome proliferator-activated receptors (PPAR) in atherosclerosis

21 January 2018

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Liver-specific catalase expression in transgenic mice inhibits NF-kappaB activation and DNA synthesis induced by the peroxisome proliferator ciprofibrate

21 January 2018

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On the mechanism of the hepatocarcinogenicity of peroxisome proliferators

21 January 2018

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Effect of three tumour promoters on the stability of hepatocyte cultures and apoptosis after transforming growth factor-beta 1.

21 January 2018

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Evaluation of Tier I screening approaches for detecting endocrine-active compounds (EACs).

21 January 2018

1 reference

Promoting activity of di(2-ethylhexyl)phthalate in rat liver foci bioassay

21 January 2018

1 reference

Testicular cancer and occupational exposures with a focus on xenoestrogens in polyvinyl chloride plastics

21 January 2018

1 reference

Plasma cholecystokinin and hepatic enzymes, cholesterol and lipoproteins in ammonium perfluorooctanoate production workers

21 January 2018

1 reference

Effect of rodent hepatocarcinogenic peroxisome proliferators on fatty acyl-CoA oxidase, DNA synthesis, and apoptosis in cultured human and rat hepatocytes

21 January 2018

1 reference

Role of peroxisome proliferator-activated receptor alpha in altered cell cycle regulation in mouse liver.

21 January 2018

1 reference

Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643.

21 January 2018

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Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice

21 January 2018

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Peroxisome proliferator-activated receptor alpha is restricted to hepatic parenchymal cells, not Kupffer cells: implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis.

21 January 2018

1 reference

Activation of a human peroxisome proliferator-activated receptor by the antitumor agent phenylacetate and its analogs.

21 January 2018

1 reference

Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-alpha-mediated downregulation of cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase expression

21 January 2018

1 reference

Effect of cholecystokinin on pancreatic carcinogenesis in the hamster model.

21 January 2018

1 reference

A review of drug-induced Leydig cell hyperplasia and neoplasia in the rat and some comparisons with man.

21 January 2018

1 reference

Species differences in response to trichloroethylene. I. Pharmacokinetics in rats and mice.

21 January 2018

1 reference

A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis

21 January 2018

1 reference

Mechanism of clofibrate hepatotoxicity: mitochondrial damage and oxidative stress in hepatocytes

21 January 2018

1 reference

Induction of peroxisome proliferation and hepatic tumours in C57BL/6N mice by ciprofibrate, a hypolipidaemic compound

21 January 2018

1 reference

Peroxisome proliferator-induced pleiotropic responses: pursuit of a phenomenon

21 January 2018

1 reference

Transcription regulation of peroxisomal fatty acyl-CoA oxidase and enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase in rat liver by peroxisome proliferators

21 January 2018

1 reference

Carcinogenesis by Hepatic Peroxisome Proliferators: Evaluation of the Risk of Hypolipidemic Drugs and Industrial Plasticizers to Humans

21 January 2018

1 reference

Tumorigenicity of the hypolipidaemic peroxisome proliferator ethyl-α-p-chlorophenoxyisobutyrate (clofibrate) in rats

21 January 2018

1 reference

Oxidative DNA damage caused by persistent peroxisome proliferation: its role in hepatocarcinogenesis

21 January 2018

1 reference

Malignant Tumors in Rats Fed Nafenopin, a Hepatic Peroxisome Proliferator 2

21 January 2018

1 reference

The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation

21 January 2018

1 reference

Cytokines in non-genotoxic hepatocarcinogenesis

21 January 2018

1 reference

Non-genotoxic hepatocarcinogens stimulate DNA synthesis and their withdrawal induces apoptosis, but in different hepatocyte populations.

21 January 2018

1 reference

Glucose Down-regulates the Expression of the Peroxisome Proliferator-activated Receptor-α Gene in the Pancreatic β-Cell

21 January 2018

1 reference

Fibrate treatment does not modify the expression of acyl coenzyme A oxidase in human liver

21 January 2018

1 reference

Dietary glycine prevents increases in hepatocyte proliferation caused by the peroxisome proliferator WY-14,643.

21 January 2018

1 reference

Role of Kupffer cells and oxidants in signaling peroxisome proliferator-induced hepatocyte proliferation

21 January 2018

1 reference

Gonadotropin-Independent Familial Sexual Precocity with Premature Leydig and Germinal Cell Maturation (Familial Testotoxicosis): Effects of a Potent Luteinizing Hormone-Releasing Factor Agonist and Medroxyprogesterone Acetate Therapy in Four Cases*

21 January 2018

1 reference

The effects of tiadenol, clofibrate and clofibride on bile composition in the rat

21 January 2018

1 reference

Expression of base excision repair enzymes in rat and mouse liver is induced by peroxisome proliferators and is dependent upon carcinogenic potency.

21 January 2018

1 reference

Novel role of oxidants in the molecular mechanism of action of peroxisome proliferators

21 January 2018

1 reference

WY-14 643 rapidly activates nuclear factor kappaB in Kupffer cells before hepatocytes.

21 January 2018

1 reference

Mechanism of action of gemfibrozil on lipoprotein metabolism

21 January 2018

1 reference

A potent antihypercholesterolemic agent: (4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio) acetic acid (Wy-14643).

21 January 2018

1 reference

The human peroxisome proliferator-activated receptor alpha gene: identification and functional characterization of two natural allelic variants.

21 January 2018

1 reference

Elevated 8-hydroxydeoxyguanosine in hepatic DNA of rats following exposure to peroxisome proliferators: relationship to mitochondrial alterations.

21 January 2018

1 reference

Long-term toxicologic and tumorigenesis studies on an oral contraceptive agent in albino rats

21 January 2018

1 reference

Testicular leydig cell hyperplasia as a cause of familial sexual precocity

21 January 2018

1 reference

Various short-term assays and two long-term studies with the plasticizer di(2-ethylhexyl)phthalate in the Syrian golden hamster.

21 January 2018

1 reference

Excretion and metabolism of di(2-ethylhexyl)phthalate in man.

21 January 2018

1 reference

The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation

21 January 2018

1 reference

Induction of the acyl-coenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter

21 January 2018

1 reference

Recent advances in peroxisome proliferator-activated receptor science

21 January 2018

1 reference

A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty

21 January 2018

1 reference

cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor

21 January 2018

1 reference

Metabolic and peroxisome proliferation studies with di(2-ethylhexyl)phthalate in rats and monkeys.

21 January 2018

1 reference

Characteristics of interaction of the antiandrogen flutamide with the androgen receptor in various target tissues.

21 January 2018

1 reference

Isolation of human Leydig cells which are highly responsive to human chorionic gonadotropin

21 January 2018

1 reference

Correlation of the carcinogenic potential of di(2-ethylhexyl)phthalate (DEHP) with induced hyperplasia rather than with genotoxic activity.

21 January 2018

1 reference

Activation of human aortic smooth-muscle cells is inhibited by PPARalpha but not by PPARgamma activators.

21 January 2018

1 reference

The effects of fibrates and thiazolidinediones on plasma triglyceride metabolism are mediated by distinct peroxisome proliferator activated receptors (PPARs).

21 January 2018

1 reference

Fibrates influence the expression of genes involved in lipoprotein metabolism in a tissue-selective manner in the rat

21 January 2018

1 reference

Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates

21 January 2018

1 reference

Chemically induced proliferation of peroxisomes: implications for risk assessment

21 January 2018

1 reference

Selective modification of pyruvate dehydrogenase kinase isoform expression in rat pancreatic islets elicited by starvation and activation of peroxisome proliferator-activated receptor-alpha: implications for glucose-stimulated insulin secretion

21 January 2018

1 reference

Significant increase of 8-hydroxydeoxyguanosine in liver DNA of rats following short-term exposure to the peroxisome proliferators di(2-ethylhexyl)phthalate and di(2-ethylhexyl)adipate.

21 January 2018

1 reference

Effects of gemfibrozil and ketoconazole on human apolipoprotein AI, B and E levels in two hepatoma cell lines, HepG2 and Hep3B

21 January 2018

1 reference

Lack of induction of hepatic DNA damage on long-term administration of peroxisome proliferators in male F-344 rats

21 January 2018

1 reference

Differential activation of hepatic NF-kappaB in rats and hamsters by the peroxisome proliferators Wy-14,643, gemfibrozil, and dibutyl phthalate.

21 January 2018

1 reference

Alternations in hepatic expression of fatty-acid metabolizing enzymes in ArKO mice and their reversal by the treatment with 17beta-estradiol or a peroxisome proliferator

21 January 2018

1 reference

Activation of the prolactin gene by peroxisome proliferator-activated receptor-alpha appears to be DNA binding-independent

21 January 2018

1 reference

In vitro steady-state levels of hydrogen peroxide after exposure of male F344 rats and female B6C3F1 mice to hepatic peroxisome proliferators

21 January 2018

1 reference

A regulatory role for RIP140 in nuclear receptor activation

21 January 2018

1 reference

Changes in levels of 8-hydroxyguanine in DNA, its repair and OGG1 mRNA in rat lungs after intratracheal administration of diesel exhaust particles.

21 January 2018

1 reference

Peroxisome proliferator-activated receptors: structures and function

21 January 2018

1 reference

A peroxisome proliferator-activated receptor-alpha (PPARalpha) cDNA cloned from guinea-pig liver encodes a protein with similar properties to the mouse PPARalpha: implications for species differences in responses to peroxisome proliferators.

21 January 2018

1 reference

Inhibition of gap junctional intercellular communication by perfluorinated fatty acids is dependent on the chain length of the fluorinated tail

21 January 2018

1 reference

Hydrogen peroxide inhibits gap junctional intercellular communication in glutathione sufficient but not glutathione deficient cells.

21 January 2018

1 reference

Coordinate induction of acyl-CoA binding protein, fatty acid binding protein and peroxisomal beta-oxidation by peroxisome proliferators

21 January 2018

1 reference

Identification of a peroxisome proliferator-responsive element upstream of the human peroxisomal fatty acyl coenzyme A oxidase gene

21 January 2018

1 reference

The nuclear receptors peroxisome proliferator-activated receptor alpha and Rev-erbalpha mediate the species-specific regulation of apolipoprotein A-I expression by fibrates

21 January 2018

1 reference

Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor

21 January 2018

1 reference

Peroxisome proliferator activated receptors: transcriptional regulators of adipogenesis, lipid metabolism and more....

21 January 2018

1 reference

The chronic hepatic or renal toxicity of di(2-ethylhexyl) phthalate, acetaminophen, sodium barbital, and phenobarbital in male B6C3F1 mice: autoradiographic, immunohistochemical, and biochemical evidence for levels of DNA synthesis not associated wi

21 January 2018

1 reference

21 January 2018

1 reference

Cholecystokinin A and B receptors are differentially expressed in normal pancreas and pancreatic adenocarcinoma

21 January 2018

1 reference

Role for tumor necrosis factor alpha receptor 1 and interleukin-1 receptor in the suppression of mouse hepatocyte apoptosis by the peroxisome proliferator nafenopin

21 January 2018

1 reference

The PPARs: from orphan receptors to drug discovery

21 January 2018

1 reference

21 January 2018

Human DNA repair genes

1 reference

The peroxisome proliferator (PP) response element upstream of the human acyl CoA oxidase gene is inactive among a sample human population: significance for species differences in response to PPs.

21 January 2018

1 reference

Pharmacological analysis of wild-type alpha, gamma and delta subtypes of the human peroxisome proliferator-activated receptor

21 January 2018

1 reference

Apoptosis (the 1992 Frank Rose Memorial Lecture).

21 January 2018

1 reference

Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors

21 January 2018

1 reference

A Val227Ala polymorphism in the peroxisome proliferator activated receptor alpha (PPARalpha) gene is associated with variations in serum lipid levels

21 January 2018

1 reference

Gap junctional intercellular communication and carcinogenesis

21 January 2018

1 reference

Regulation of peroxisome proliferator-activated receptor alpha-induced transactivation by the nuclear orphan receptor TAK1/TR4

21 January 2018

1 reference

Involvement of the peroxisome proliferator-activated receptor alpha in the immunomodulation caused by peroxisome proliferators in mice

21 January 2018

1 reference

Hydrogen peroxide generation in peroxisome proliferator-induced oncogenesis

21 January 2018

1 reference

Human peroxisome proliferator-activated receptor alpha (PPARalpha) supports the induction of peroxisome proliferation in PPARalpha-deficient mouse liver

21 January 2018

1 reference

The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion

21 January 2018

1 reference

Novel pathway for thyroid hormone receptor action through interaction with jun and fos oncogene activities

21 January 2018

1 reference

Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR

21 January 2018

1 reference

Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor

21 January 2018

1 reference

Peroxisome Proliferators: Species Differences in Response of Primary Hepatocyte Cultures

21 January 2018

1 reference

NATURE OF THE HEPATOMEGALIC EFFECT PRODUCED BY ETHYL-CHLOROPHENOXY-ISOBUTYRATE IN THE RAT

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1080/713608372

1 reference

9 August 2017

1 reference