Mechanism of clofibrate hepatotoxicity: mitochondrial damage and oxidative stress in hepatocytes (Q40783710)

23 September 2017

Mechanism of clofibrate hepatotoxicity: mitochondrial damage and oxidative stress in hepatocytes (English)

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23 September 2017

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Qu B

1

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23 September 2017

Li QT

2

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23 September 2017

Wong KP

3

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23 September 2017

Tan TM

4

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23 September 2017

Halliwell B

5

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23 September 2017

1 September 2001

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Free Radical Biology and Medicine

23 September 2017

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23 September 2017

31

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23 September 2017

5

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23 September 2017

659-669

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Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens

23 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Suppression of liver cell apoptosis in vitro by the non-genotoxic hepatocarcinogen and peroxisome proliferator nafenopin

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Effect of the peroxisome proliferator ciprofibrate on lipid peroxidation and 8-hydroxydeoxyguanosine formation in transgenic mice with elevated hepatic catalase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Hydrogen peroxide generation in peroxisome proliferator-induced oncogenesis

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https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Hepatocarcinogenesis of peroxisome proliferators

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https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Mechanism of action of the nongenotoxic peroxisome proliferators: role of the peroxisome proliferator-activator receptor alpha.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Role of Kupffer cells and oxidants in signaling peroxisome proliferator-induced hepatocyte proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Induction of peroxisomes by treatment with perfluorooctanoate does not increase rates of H2O2 production in intact liver

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Evidence against peroxisome proliferation-induced hepatic oxidative damage

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Thyromimetic action of the peroxisome proliferators clofibrate, perfluorooctanoic acid, and acetylsalicylic acid includes changes in mRNA levels for certain genes involved in mitochondrial biogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

A 45 kDa protein related to PPARgamma2, induced by peroxisome proliferators, is located in the mitochondrial matrix

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Effects of hypolipidaemics cetaben and clofibrate on mitochondrial and peroxisomal enzymes of rat liver

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha)

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Mechanism of phthalate-induced inhibition of hepatic mitochondrial beta-oxidation

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Inhibition of mitochondrial respiration and oxygen-dependent hepatotoxicity by six structurally dissimilar peroxisomal proliferating agents

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

The effect of peroxisome proliferators on mitochondrial bioenergetics.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Mitochondrial damage by the "pro-oxidant" peroxisomal proliferator clofibrate

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Establishment and characterization of differentiated, nontransformed hepatocyte cell lines derived from mice transgenic for transforming growth factor alpha

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https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill

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https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Effects of oxidants and glutamate receptor activation on mitochondrial membrane potential in rat forebrain neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Bcl-2 protects against FCCP-induced apoptosis and mitochondrial membrane potential depolarization in PC12 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Prevention of mitochondrial injury by manganese superoxide dismutase reveals a primary mechanism for alkaline-induced cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Oxidative stress on mitochondria and cell membrane of cultured rat hepatocytes and perfused liver exposed to ethanol

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Mitochondrial permeability transition and swelling can occur reversibly without inducing cell death in intact human cells

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https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Depolarization of in situ mitochondria due to hydrogen peroxide-induced oxidative stress in nerve terminals: inhibition of alpha-ketoglutarate dehydrogenase.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

The mitochondrial permeability transition in toxic, hypoxic and reperfusion injury

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Mitochondrial disease in superoxide dismutase 2 mutant mice

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https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Mitochondrial phospholipid hydroperoxide glutathione peroxidase plays a major role in preventing oxidative injury to cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Changes in antioxidant defence systems induced by cyclosporine A in cultures of hepatocytes from 2- and 12-month-old rats

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

The role of intracellular oxidants in apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Mitochondria and programmed cell death: back to the future.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Requirement for superoxide in excitotoxic cell death.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

The proto-oncogene Bcl-2 and its role in regulating apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

S-nitrosylation regulates apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Reactive Oxygen Species Regulate Activation-Induced T Cell Apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Titrating the effects of mitochondrial complex I impairment in the cell physiology

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Mitochondria and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Protease activation during apoptosis: death by a thousand cuts?

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Contribution of increased mitochondrial free Ca2+ to the mitochondrial permeability transition induced by tert-butylhydroperoxide in rat hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Commitment to apoptosis is associated with changes in mitochondrial biogenesis and activity in cell lines conditionally immortalized with simian virus 40.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Opening of the mitochondrial permeability transition pore by uncoupling or inorganic phosphate in the presence of Ca2+ is dependent on mitochondrial-generated reactive oxygen species.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900632-3

7 January 2021

10.1016/S0891-5849(01)00632-3

Identifiers

DOI

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23 September 2017

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