G proteins in cancer: the prostate cancer paradigm (Q35634255)

9 August 2017

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title

G proteins in cancer: the prostate cancer paradigm (English)

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9 August 2017

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Yehia Daaka

1

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9 August 2017

13 January 2004

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Science's STKE : signal transduction knowledge environment

9 August 2017

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9 August 2017

2004

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9 August 2017

216

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9 August 2017

re2

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9 August 2017

Cancer statistics, 2003.

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Pathological and molecular aspects of prostate cancer

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Independent origin of multiple foci of prostatic intraepithelial neoplasia: comparison with matched foci of prostate carcinoma.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Androgens and prostate cancer

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

What's new in the treatment of advanced prostate cancer?

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Critical evaluation of hormonal therapy for carcinoma of the prostate

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

The development of androgen-independent prostate cancer

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Focus on prostate cancer.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Androgen receptor signaling in androgen-refractory prostate cancer

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Androgens and androgen receptor in prostate and ovarian malignancies.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Role of the androgen receptor axis in prostate cancer

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Dysregulated expression of growth factors and their receptors in the development of prostate cancer

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Molecular action of androgen in the normal and neoplastic prostate

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Activation of the androgen receptor by polypeptide growth factors and cellular regulators

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

8-Bromo-cyclic AMP induces phosphorylation of two sites in SRC-1 that facilitate ligand-independent activation of the chicken progesterone receptor and are critical for functional cooperation between SRC-1 and CREB binding protein

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Androgen Receptor (AR) Coregulators: An Overview

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Seven-transmembrane receptors

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Mitogenic action of LPA in prostate

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Human glandular kallikrein 2: a potential serum marker for predicting the organ confined versus non-organ confined growth of prostate cancer.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

The endothelin axis: emerging role in cancer

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

The emerging role of lysophosphatidic acid in cancer

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Endothelin Inhibition: Novel Therapy for Prostate Cancer

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Effect of endothelin-A receptor blockade with atrasentan on tumor progression in men with hormone-refractory prostate cancer: a randomized, phase II, placebo-controlled trial

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

G-proteins as transducers in transmembrane signalling

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

cAMP effector mechanisms. Novel twists for an 'old' signaling system

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Rap1 signalling: adhering to new models

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Heterotrimeric G-protein betagamma-dimers in growth and differentiation

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Oncogenic kinase signalling

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Evolutionary aspects of oncogenic herpesviruses

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Two G protein oncogenes in human endocrine tumors

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Potent transforming activity of the G13 alpha subunit defines a novel family of oncogenes

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

A mutant alpha subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Interleukin-6- and cyclic AMP-mediated signaling potentiates neuroendocrine differentiation of LNCaP prostate tumor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Bombesin stimulates the motility of human prostate-carcinoma cells through tyrosine phosphorylation of focal adhesion kinase and of integrin-associated proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Transactivation of ErbB1 and ErbB2 receptors by angiotensin II in normal human prostate stromal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Neuropeptide-induced androgen independence in prostate cancer cells: roles of nonreceptor tyrosine kinases Etk/Bmx, Src, and focal adhesion kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Requirement for direct cross-talk between B1 and B2 kinin receptors for the proliferation of androgen-insensitive prostate cancer PC3 cells

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Lysophosphatidic acid-regulated mitogenic ERK signaling in androgen-insensitive prostate cancer PC-3 cells

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Neurotensin receptor expression in prostate cancer cell line and growth effect of NT at physiological concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Prostaglandin E2 induces hypoxia-inducible factor-1alpha stabilization and nuclear localization in a human prostate cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

A functional thrombin receptor (PAR1) is expressed on bone-derived prostate cancer cell lines.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Mitogen-activated protein kinases: specific messages from ubiquitous messengers

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Galpha and Gbeta gamma require distinct Src-dependent pathways to activate Rap1 and Ras.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Protein kinase C alpha activates RAF-1 by direct phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

The m1 muscarinic acetylcholine receptor transactivates the EGF receptor to modulate ion channel activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Mechanism of biological synergy between cellular Src and epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Targeting Gbetagamma signaling to inhibit prostate tumor formation and growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Her-2-neu expression and progression toward androgen independence in human prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Deregulated expression of insulin-like growth factor 1 in prostate epithelium leads to neoplasia in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Pertussis toxin-sensitive and -insensitive thrombin stimulation of Shc phosphorylation and mitogenesis are mediated through distinct pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Coupling of the insulin-like growth factor-I receptor tyrosine kinase to Gi2 in human intestinal smooth muscle: Gbetagamma -dependent mitogen-activated protein kinase activation and growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Androgen receptor phosphorylation. Regulation and identification of the phosphorylation sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Activation of the androgen receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Activation of the human androgen receptor through a protein kinase A signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

FHL2, a novel tissue-specific coactivator of the androgen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

A novel inducible transactivation domain in the androgen receptor: implications for PRK in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Humoral mechanisms in prostate cancer: A role for FSH

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Role for 18:1 lysophosphatidic acid as an autocrine mediator in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Hormone-refractory prostate cancer cells express functional follicle-stimulating hormone receptor (FSHR)

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Expression of endothelin receptor a associated with prostate cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

A magnificent time with the "magnificent seven" transmembrane spanning receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

G protein-coupled receptor kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Essential role for G proteins in prostate cancer cell growth and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Epidermal growth factor (EGF) receptor-dependent ERK activation by G protein-coupled receptors: a co-culture system for identifying intermediates upstream and downstream of heparin-binding EGF shedding

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Plasma insulin-like growth factor-I, insulin-like growth factor-binding proteins, and prostate cancer risk: a prospective study

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Changes in the abundance of androgen receptor isotypes: effects of ligand treatment, glutamine-stretch variation, and mutation of putative phosphorylation sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

Androgen-independent induction of prostate-specific antigen gene expression via cross-talk between the androgen receptor and protein kinase A signal transduction pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2162004RE2

21 January 2018

Identifiers

DOI

10.1126/STKE.2162004RE2

1 reference

9 August 2017

1 reference

PubMed ID

14734786