DNA repair factor MRE11/RAD50 cleaves 3'-phosphotyrosyl bonds and resects DNA to repair damage caused by topoisomerase 1 poisons. (Q35639890)

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15 January 2020

title

DNA repair factor MRE11/RAD50 cleaves 3'-phosphotyrosyl bonds and resects DNA to repair damage caused by topoisomerase 1 poisons (English)

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15 January 2020

1

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15 January 2020

author name string

Nancy Maizels

series ordinal

2

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15 January 2020

language of work or name

English

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publication date

28 October 2011

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Journal of Biological Chemistry

15 January 2020

published in

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15 January 2020

volume

286

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15 January 2020

issue

52

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15 January 2020

page(s)

44945-44951

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The Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break Repair

15 January 2020

cites work

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ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair.

12 July 2018

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MRE11 function in response to topoisomerase poisons is independent of its function in double-strand break repair in Saccharomyces cerevisiae

12 July 2018

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Structural basis for adenylate kinase activity in ABC ATPases

12 July 2018

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The mre11 complex and the response to dysfunctional telomeres

12 July 2018

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RAD50, an SMC family member with multiple roles in DNA break repair: how does ATP affect function?

12 July 2018

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Working together and apart: the twisted relationship of the Mre11 complex and Chk2 in apoptosis and tumor suppression.

12 July 2018

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Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

12 July 2018

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DNA mismatch repair and colon cancer

12 July 2018

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A mutant allele of MRE11 found in mismatch repair-deficient tumor cells suppresses the cellular response to DNA replication fork stress in a dominant negative manner

12 July 2018

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Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes

12 July 2018

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Repair of topoisomerase I-mediated DNA damage

12 July 2018

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Mutations in Mre11 phosphoesterase motif I that impair Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex stability in addition to nuclease activity

12 July 2018

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Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages

12 July 2018

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Endonucleolytic processing of covalent protein-linked DNA double-strand breaks

12 July 2018

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The MRE11-RAD50-NBS1 complex accelerates somatic hypermutation and gene conversion of immunoglobulin variable regions

12 July 2018

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Multiple endonucleases function to repair covalent topoisomerase I complexes in Saccharomyces cerevisiae

12 July 2018

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The role of TDP1 from budding yeast in the repair of DNA damage

12 July 2018

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Role of the nuclease activity of Saccharomyces cerevisiae Mre11 in repair of DNA double-strand breaks in mitotic cells.

12 July 2018

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DNA repair functions that control sensitivity to topoisomerase-targeting drugs

12 July 2018

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The rad50 signature motif: essential to ATP binding and biological function

12 July 2018

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The Mechanism of Mus81-Mms4 Cleavage Site Selection Distinguishes It from the Homologous Endonuclease Rad1-Rad10

12 July 2018

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Repair of topoisomerase I covalent complexes in the absence of the tyrosyl-DNA phosphodiesterase Tdp1.

12 July 2018

1 reference

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DNA end-binding specificity of human Rad50/Mre11 is influenced by ATP.

12 July 2018

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Yeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Top1 replicative damage

12 July 2018

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Cellular roles of dna topoisomerases: a molecular perspective

12 July 2018

1 reference

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Human MRE11 is inactivated in mismatch repair-deficient cancers

12 July 2018

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The tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamily

12 July 2018

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DNA topoisomerases: structure, function, and mechanism

12 July 2018

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Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase

12 July 2018

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Mre11 and Rad50 from Pyrococcus furiosus: cloning and biochemical characterization reveal an evolutionarily conserved multiprotein machine

12 July 2018

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Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily

12 July 2018

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Alteration of N-terminal phosphoesterase signature motifs inactivates Saccharomyces cerevisiae Mre11.

12 July 2018

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Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95

12 July 2018

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The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

12 July 2018

1 reference

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Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types.

12 July 2018

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A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases

12 July 2018

1 reference

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MRE11/RAD50 cleaves DNA in the AID/UNG-dependent pathway of immunoglobulin gene diversification

12 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.299347

The P. furiosus mre11/rad50 complex promotes 5' strand resection at a DNA double-strand break

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.299347

The Mre11/Rad50/Nbs1 complex and its role as a DNA double-strand break sensor for ATM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.299347

Frequent alteration of DNA damage signalling and repair pathways in human colorectal cancers with microsatellite instability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.299347

21 January 2018

Identifiers

DOI

10.1074/JBC.M111.299347

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22039049%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22039049%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

PubMed publication ID

22039049

1 reference