Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection. (Q35641516)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22160724%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

title

Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection (English)

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18 January 2020

4

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18 January 2020

Sang-Jun Ha

5

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18 January 2020

Lilin Ye

7

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18 January 2020

10

Rafi Ahmed

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18 January 2020

2

Alice O Kamphorst

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18 January 2020

9

Gordon J Freeman

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18 January 2020

8

Arlene H Sharpe

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18 January 2020

author name string

Rachael D Aubert

1

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18 January 2020

Surojit Sarkar

3

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18 January 2020

Daniel L Barber

6

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18 January 2020

language of work or name

English

0 references

publication date

12 December 2011

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18 January 2020

number of pages

6

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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18 January 2020

volume

108

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18 January 2020

issue

52

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18 January 2020

page(s)

21182-21187

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22160724%20AND%20SRC:MED&resulttype=core&format=json

Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells

18 January 2020

cites work

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HIV-1-specific interleukin-21+ CD4+ T cell responses contribute to durable viral control through the modulation of HIV-specific CD8+ T cell function

12 July 2018

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Features of responding T cells in cancer and chronic infection.

12 July 2018

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Redefining chronic viral infection

12 July 2018

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A vital role for interleukin-21 in the control of a chronic viral infection

12 July 2018

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IL-21 is required to control chronic viral infection

12 July 2018

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Impaired antibody response causes persistence of prototypic T cell-contained virus

12 July 2018

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Adoptive transfer of virus-specific and tumor-specific T cell immunity

12 July 2018

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Adoptive immunotherapy of cancer using CD4(+) T cells

12 July 2018

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Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade

12 July 2018

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Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1

12 July 2018

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PD-1 and its ligands in tolerance and immunity

12 July 2018

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Spontaneous recovery in acute human hepatitis C virus infection: functional T-cell thresholds and relative importance of CD4 help

12 July 2018

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Molecular signature of CD8+ T cell exhaustion during chronic viral infection.

12 July 2018

1 reference

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Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection

12 July 2018

1 reference

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Principles of adoptive T cell cancer therapy

12 July 2018

1 reference

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Restoring function in exhausted CD8 T cells during chronic viral infection

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248546

Mutational escape from CD8+ T cell immunity: HCV evolution, from chimpanzees to man

12 July 2018

1 reference

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Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells

12 July 2018

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Cancer immunotherapy: a treatment for the masses

12 July 2018

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HCV Persistence and Immune Evasion in the Absence of Memory T Cell Help

12 July 2018

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Adoptive immunotherapy: engineering T cell responses as biologic weapons for tumor mass destruction

12 July 2018

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Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment

12 July 2018

1 reference

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Adoptive therapy with CD8(+) T cells: it may get by with a little help from its friends

12 July 2018

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Association between virus-specific cytotoxic T-lymphocyte and helper responses in human immunodeficiency virus type 1 infection

12 July 2018

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Viral immune evasion due to persistence of activated T cells without effector function

12 July 2018

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Progressive loss of CD8+ T cell-mediated control of a gamma-herpesvirus in the absence of CD4+ T cells

12 July 2018

1 reference

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CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection

12 July 2018

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Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice.

12 July 2018

1 reference

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Immunity to lymphocytic choriomeningitis virus in B cell-depleted mice: evidence for B cell and antibody-independent protection by memory T cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248546

IL-21R on T cells is critical for sustained functionality and control of chronic viral infection

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248546

Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction

25 September 2018

1 reference

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Chronic lymphocytic choriomeningitis virus infection actively down-regulates CD4+ T cell responses directed against a broad range of epitopes

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248546

Mapping and restriction of a dominant viral CD4+ T cell core epitope by both MHC class I and MHC class II.

25 September 2018

1 reference

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Maintenance of memory CTL responses by T helper cells and CD40-CD40 ligand: antibodies provide the key.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248546

Comparison of activation versus induction of unresponsiveness of virus-specific CD4+ and CD8+ T cells upon acute versus persistent viral infection

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248546

Infusion of cytotoxic T cells for the prevention and treatment of Epstein-Barr virus-induced lymphoma in allogeneic transplant recipients.

25 September 2018

1 reference

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T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248546

Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248546

Virus-specific MHC-class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection

25 September 2018

1 reference

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Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence

25 September 2018

1 reference

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Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression

25 September 2018

1 reference

12 December 2020

Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo

1 reference

12 December 2020

CD4+ T cell clones specific for the human p97 melanoma-associated antigen can eradicate pulmonary metastases from a murine tumor expressing the p97 antigen

1 reference

12 December 2020

Reconstitution of Cellular Immunity against Cytomegalovirus in Recipients of Allogeneic Bone Marrow by Transfer of T-Cell Clones from the Donor

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1118450109

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22160724%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

0 references

1 reference

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18 January 2020

PubMed publication ID

22160724

1 reference