Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells (Q34973705)

5 August 2017

Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells (English)

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5 August 2017

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Laura M Fahey

1

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5 August 2017

Elizabeth B Wilson

2

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5 August 2017

Heidi Elsaesser

3

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5 August 2017

Chris D Fistonich

4

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5 August 2017

Dorian B McGavern

5

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5 August 2017

David G Brooks

6

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5 August 2017

language of work or name

English

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publication date

2 May 2011

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Journal of Experimental Medicine

5 August 2017

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5 August 2017

208

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5 August 2017

987-999

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5 August 2017

5

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Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling.

5 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

Signals that influence T follicular helper cell differentiation and function.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

Bcl6 mediates the development of T follicular helper cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

A vital role for interleukin-21 in the control of a chronic viral infection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

IL-21 is required to control chronic viral infection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

T follicular helper cells differentiate from Th2 cells in response to helminth antigens

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

Impaired antibody response causes persistence of prototypic T cell-contained virus

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

Cytokine-secreting follicular T cells shape the antibody repertoire

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

Extralymphatic virus sanctuaries as a consequence of potent T-cell activation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

Molecular signature of CD8+ T cell exhaustion during chronic viral infection.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

Viral antigen and extensive division maintain virus-specific CD8 T cells during chronic infection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

Interleukin-10 determines viral clearance or persistence in vivo

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

Reprogramming of antiviral T cells prevents inactivation and restores T cell activity during persistent viral infection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

Restoring function in exhausted CD8 T cells during chronic viral infection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

T cells and viral persistence: lessons from diverse infections

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

Initial T cell frequency dictates memory CD8+ T cell lineage commitment

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

Public, private and non-specific antibodies induced by non-cytopathic viral infections

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

A critical role for IL-21 in regulating immunoglobulin production

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

Impairment of CD4(+) T cell responses during chronic virus infection prevents neutralizing antibody responses against virus escape mutants

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

Viral immune evasion due to persistence of activated T cells without effector function

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

Protective immunity does not correlate with the hierarchy of virus-specific cytotoxic T cell responses to naturally processed peptides

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of antigen-presenting cells and lymph follicle structure

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

IL-21R on T cells is critical for sustained functionality and control of chronic viral infection

8 July 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20101773

Ablation of CD8 and CD4 T cell responses by high viral loads

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20101773

Viruses evade the immune system through type I interferon-mediated STAT2-dependent, but STAT1-independent, signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20101773

Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20101773

Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20101773

Molecular and functional profiling of memory CD8 T cell differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20101773

The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20101773

CXCR5-deficient mice develop functional germinal centers in the splenic T cell zone.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

Virus-specific MHC-class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

Exhaustion of CTL memory and recrudescence of viremia in lymphocytic choriomeningitis virus-infected MHC class II-deficient mice and B cell-deficient mice

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092345

Hypergammaglobulinemia and autoantibody induction mechanisms in viral infections

26 October 2018

1 reference

12 December 2020

Designing and maintaining the mature TCR repertoire: the continuum of self-peptide:self-MHC complex recognition

1 reference

12 December 2020

CXCR5-dependent seeding of follicular niches by B and Th cells augments antiviral B cell responses

1 reference

12 December 2020

c-Maf activates the promoter and enhancer of the IL-21 gene, and TGF-β inhibits c-Maf-induced IL-21 production in CD4+ T cells

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20101773

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5 August 2017

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5 August 2017

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