3-Hydroxy-3-methylglutaryl CoA reductase inhibitors up-regulate transforming growth factor-beta signaling in cultured heart cells via inhibition of geranylgeranylation of RhoA GTPase (Q35654989)

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scientific article published on September 1999

Language	Label	Description	Also known as
English	3-Hydroxy-3-methylglutaryl CoA reductase inhibitors up-regulate transforming growth factor-beta signaling in cultured heart cells via inhibition of geranylgeranylation of RhoA GTPase	scientific article published on September 1999

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

3-Hydroxy-3-methylglutaryl CoA reductase inhibitors up-regulate transforming growth factor-beta signaling in cultured heart cells via inhibition of geranylgeranylation of RhoA GTPase (English)

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

author name string

H J Park

1

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

J B Galper

2

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

language of work or name

0 references

publication date

1 September 1999

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Proceedings of the National Academy of Sciences of the United States of America

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Europe PubMed Central

PubMed publication ID

9 August 2017

96

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

20

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

11525-11530

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

p21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor beta- and Sp1-responsive element: involvement of the small GTPase rhoA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18067

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3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors increase fibrinolytic activity in rat aortic endothelial cells. Role of geranylgeranylation and Rho proteins

1 reference

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12 July 2018

NK-104, a newly developed HMG-CoA reductase inhibitor, suppresses neointimal thickening by inhibiting smooth muscle cell growth and fibronectin production in balloon-injured rabbit carotid artery

1 reference

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Cytokine regulation of low-density lipoprotein receptor gene transcription in human mesangial cells

1 reference

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12 July 2018

Inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase pathway induces p53-independent transcriptional regulation of p21(WAF1/CIP1) in human prostate carcinoma cells

1 reference

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12 July 2018

Hydrophilicity/lipophilicity: relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitors

1 reference

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Induction of the cholesterol metabolic pathway regulates the farnesylation of RAS in embryonic chick heart cells: a new role for ras in regulating the expression of muscarinic receptors and G proteins

1 reference

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TGF-beta signalling from cell membrane to nucleus through SMAD proteins

1 reference

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12 July 2018

The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner

1 reference

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Circulating transforming growth factor beta 1 and coronary artery disease.

1 reference

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1 reference

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Clinical pharmacokinetics of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors

1 reference

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1 reference

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TGFbeta signaling: receptors, transducers, and Mad proteins.

1 reference

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12 July 2018

Extracellular signal-regulated kinase and the small GTP-binding protein, Rac, contribute to the effects of transforming growth factor-beta1 on gene expression

1 reference

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12 July 2018

Emerging concepts in the Ras superfamily of GTP-binding proteins.

1 reference

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Hypertrophic stimuli induce transforming growth factor-beta 1 expression in rat ventricular myocytes

1 reference

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Disruption of transforming growth factor beta signaling by a mutation that prevents transphosphorylation within the receptor complex.

1 reference

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12 July 2018

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism

1 reference

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Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes

1 reference

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12 July 2018

Characterization of the promoter region of the human transforming growth factor-beta type II receptor gene

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Purification and assay of recombinant C3 transferase

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Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth

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Effects of low density lipoproteins and mevinolin on cholesterol content and muscarinic cholinergic responsiveness in cultured chick atrial cells. Regulation of levels of muscarinic receptors and guanine nucleotide regulatory proteins.

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Transforming growth factor beta-1 in acute myocardial infarction in rats

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Protein isoprenylation and methylation at carboxyl-terminal cysteine residues

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Identifiers

10.1073/PNAS.96.20.11525

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

1999PNAS...9611525P

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

ResearchGate publication ID

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